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2016

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Full-Text Articles in Other Physics

Static Magnetic Field Interactions Of Medical Devices In The Mri Environment, Spencer Baird Parent Dec 2016

Static Magnetic Field Interactions Of Medical Devices In The Mri Environment, Spencer Baird Parent

Electronic Thesis and Dissertation Repository

Background: The current procedures and guidelines for testing medical devices require that conservative testing be carried-out using the “worst-case” device or device configuration for each interaction (force, torque, heating, et cetera) of importance, and the results of those tests be used to inform regulatory labeling for that device. One of the most difficult elements of carrying out the above procedure is the determination of what represents a “worst-case” device or device configuration. A simulation “pipeline” would enable a systematic procedure for identification of the worst-case device or device configuration for magnetic force from an otherwise impossibly large set of options. …


Effects Of Time And Diffusion Phase-Lags In A Thick Circular Plate Due To A Ring Load With Axisymmetric Heat Supply, R. Kumar, N. Sharma, P. Lata Dec 2016

Effects Of Time And Diffusion Phase-Lags In A Thick Circular Plate Due To A Ring Load With Axisymmetric Heat Supply, R. Kumar, N. Sharma, P. Lata

Applications and Applied Mathematics: An International Journal (AAM)

The purpose of this paper is to depict the effect of time, thermal, and diffusion phase lags due to axisymmetric heat supply in a ring. The problem is discussed within the context of DPLT and DPLD models. The upper and lower surfaces of the ring are traction-free and subjected to an axisymmetric heat supply. The solution is found by using Laplace and Hankel transform techniques. The analytical expressions of displacements, stresses and chemical potential, temperature and mass concentration are computed in transformed domain. Numerical inversion technique has been applied to obtain the results in the physical domain. Numerically simulated results …


Novel Simulation To Avoid Bias In Measurement Of Hyperpolarized Pyruvate: Demonstrated In Phantom And In Vivo, Christopher M. Walker Dec 2016

Novel Simulation To Avoid Bias In Measurement Of Hyperpolarized Pyruvate: Demonstrated In Phantom And In Vivo, Christopher M. Walker

Dissertations & Theses (Open Access)

Dynamic nuclear polarization creates a transient hyperpolarized nuclear state that can dramatically increase the signal detected by magnetic resonance imaging. This signal increase allows real-time spectroscopic imaging of specific metabolites in vivo by magnetic resonance. Real-time imaging of both the spatial and chemical fate of hyperpolarized metabolites is showing great promise to meaningfully benefit clinical care of cancer patients. Imaging of hyperpolarized agents will have a larger clinical impact if it can function as a quantitative modality upon which clinical decisions can be made. However, quantitative measurement of hyperpolarized agents is currently difficult due to the restrictions imposed by the …


Heat And Mass Transfer In Mhd Micropolar Fluid In The Presence Of Diffusion Thermo And Chemical Reaction, R. V. M.S.S Kirankumar1, V. C. C.Raju, P. D. Prasad, S. V. Varma Dec 2016

Heat And Mass Transfer In Mhd Micropolar Fluid In The Presence Of Diffusion Thermo And Chemical Reaction, R. V. M.S.S Kirankumar1, V. C. C.Raju, P. D. Prasad, S. V. Varma

Applications and Applied Mathematics: An International Journal (AAM)

This work is devoted to investigating the influence of diffusion thermo effect on hydromagnetic heat and mass transfer oscillatory flow of a micropolar fluid over an infinite moving vertical permeable plate in a saturated porous medium in the presence of transverse magnetic field and chemical reaction. The dimensionless equations are solved analytically using perturbation technique. The effects of the various fluid flow parameters entering into the problem on the velocity, microrotation, temperature and concentration fields within the boundary layer are discussed with the help of graphs. Also the local skin-friction coefficient, the wall couple stress coefficient, and the rates of …


Hydromagnetic Peristaltic Transportation With Porous Medium Through An Asymmetric Vertical Tapered Channel And Joule Heating, S. R. Kumar Dec 2016

Hydromagnetic Peristaltic Transportation With Porous Medium Through An Asymmetric Vertical Tapered Channel And Joule Heating, S. R. Kumar

Applications and Applied Mathematics: An International Journal (AAM)

The present paper deals with a theoretical investigation of the hydromagnetic peristaltic transportation with porous medium through coaxial asymmetric vertical tapered channel and joule heating which has been studied under the assumption of long wavelength approximations. Exact analytical expressions of axial velocity, volume flow rate, pressure gradient, temperature and heat transfer coefficient at both walls were calculated. The effects of various emerging parameters, Hartmann number, Non-uniform parameter, Prandtl number, Heat generator parameter, Brinkman number, Porous parameter are discussed through the use of graphs. We notice from the figures that the temperature of the fluid increases in the entire vertical tapered …


Non-Inflationary Bianchi Type Vi0 Model In Rosen’S Bimetric Gravity, M. S. Borkar, N. P. Gaikwad Dec 2016

Non-Inflationary Bianchi Type Vi0 Model In Rosen’S Bimetric Gravity, M. S. Borkar, N. P. Gaikwad

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we have present the solution of Bianchi type VI0 space-time by solving the Rosen’s field equations with massless scalar field φ and with constant scalar potential V(φ) for flat region. It is observed that the scalar field φ is an increasing function of time and affects the physical parameters of the model and leads to non-inflationary type solution of model, which contradicts the inflationary scenario. Other geometrical and physical properties of the model in relation to this non-inflationary model are also studied.


Complex Solutions Of The Time Fractional Gross-Pitaevskii (Gp) Equation With External Potential By Using A Reliable Method, Nasir Taghizadeh, Mona N. Foumani Dec 2016

Complex Solutions Of The Time Fractional Gross-Pitaevskii (Gp) Equation With External Potential By Using A Reliable Method, Nasir Taghizadeh, Mona N. Foumani

Applications and Applied Mathematics: An International Journal (AAM)

In this article, modified (G'/G )-expansion method is presented to establish the exact complex solutions of the time fractional Gross-Pitaevskii (GP) equation in the sense of the conformable fractional derivative. This method is an effective method in finding exact traveling wave solutions of nonlinear evolution equations (NLEEs) in mathematical physics. The present approach has the potential to be applied to other nonlinear fractional differential equations. Based on two transformations, fractional GP equation can be converted into nonlinear ordinary differential equation of integer orders. In the end, we will discuss the solutions of the fractional GP equation with external potentials.


Assessing The Potential Clinical Impact Of Variable Biological Effectiveness In Proton Radiotherapy, Christopher R. Peeler Ph.D. Dec 2016

Assessing The Potential Clinical Impact Of Variable Biological Effectiveness In Proton Radiotherapy, Christopher R. Peeler Ph.D.

Dissertations & Theses (Open Access)

It has long been known that proton radiotherapy has an increased biological effectiveness compared to traditional x-ray radiotherapy. This arises from the clustered nature of DNA damage produced by the energy deposition of protons along their tracks in medium. This effect is currently quantified in clinical settings by assigning protons a relative biological effectiveness (RBE) value of 1.1 corresponding to 10% increased effectiveness compared to photon radiation. Numerous studies have shown, however, that the RBE value of protons is variable and can deviate substantially from 1.1, but experimental data on RBE and clinical evidence of its variability remains limited.

The …


Measuring Nonlinear Properties Of Graphene Thin Films Using Z-Scan Technique, Thekrayat Hassan Al Abdulaal Dec 2016

Measuring Nonlinear Properties Of Graphene Thin Films Using Z-Scan Technique, Thekrayat Hassan Al Abdulaal

Graduate Theses and Dissertations

The nonlinear studies of two-dimensional (2D) nanomaterials, specifically graphene, are very significant since graphene is finding its usefulness in handling the enormous heat in nanoscale high-density power electronics. Graphene has emerged to be a promising nanomaterial as an excellent heat spreader due to its high thermal conductivity. However, the experimental nonlinear study of graphene materials and their application in developing future optoelectronic devices demands for more developed research.

The research objective is first to build a precise, and sensitive technique to investigate and understand the thermal nonlinear properties, including nonlinear refractive index (n2), nonlinear absorption coefficient (β), and thermo-optic coefficient …


Jaguar Sun, Anya Nadal Nov 2016

Jaguar Sun, Anya Nadal

The STEAM Journal

Cymatics, is derived from a Greek word, meaning "wave", is a subset of modal vibrational phenomena. The term was coined by Hans Jenny, a Swiss follower of the philosophical school known as anthroposophy. This is a visual representation of the frequency field. I created this piece from acrylic on canvas based on the subtle energies I can see and feel.


Space Traffic Management Concepts Leveraging Existing Frameworks, Stephen K. Hunter Nov 2016

Space Traffic Management Concepts Leveraging Existing Frameworks, Stephen K. Hunter

Space Traffic Management Conference

Leveraging existing U.S. regulatory frameworks, as well as international organizations, will dramatically shorten the time needed to develop an effective Space Traffic Management concept. Both the Department of Defense and the Department of Transportation have been working with the U.S. Congress to define and develop a Space Traffic Management concept that will allow the Office of Commercial Space Launch to begin a new mission that will help to ensure the safety and resilience of the space domain. Outside observers can easily see forward progress toward this, still, undeveloped concept. This paper explores potential final U.S. Space Traffic Management concepts that …


Improving The Efficiency Of Gravitational Wave Detection, Jessica Page, Tyson Littenberg Oct 2016

Improving The Efficiency Of Gravitational Wave Detection, Jessica Page, Tyson Littenberg

Von Braun Symposium Student Posters

No abstract provided.


Enhancing The Science Return Of Lunar Surface Studies: Analysis Of Rediscovered Data From Apollo 17'S Lunar Seismic Profiling Experiment, Deanna Phillips, Richard Miller Oct 2016

Enhancing The Science Return Of Lunar Surface Studies: Analysis Of Rediscovered Data From Apollo 17'S Lunar Seismic Profiling Experiment, Deanna Phillips, Richard Miller

Von Braun Symposium Student Posters

No abstract provided.


Mechanical Properties Of Self-Assembled Nanoparticle Membranes: Stretching And Bending, Yifan Wang, Pongsakorn Kanjanaboos, Sean P. Mcbride, Edward Barry, Xiao-Min Lin, Heinrich M. Jaeger Oct 2016

Mechanical Properties Of Self-Assembled Nanoparticle Membranes: Stretching And Bending, Yifan Wang, Pongsakorn Kanjanaboos, Sean P. Mcbride, Edward Barry, Xiao-Min Lin, Heinrich M. Jaeger

Dr. Sean P. McBride

Monolayers composed of colloidal nanoparticles, with thickness less than ten nanometers, have remarkable mechanical strength and can suspend over micron-sized holes to form free-standing membranes. We discuss experiments probing the tensile strength and bending stiffness of these self-assembled nanoparticle sheets. The fracture behavior of monolayers and multilayers is investigated by attaching them to elastomer substrates which are then stretched. For different applied strain the fracture patterns are imaged down to the scale of single particles. The resulting detailed information about the crack width distribution allows us to relate the measured overall tensile strength to the distribution of local bond strengths …


Role Of Students’ Participation On Learning Physics In Active Learning Classes, Binod Nainabasti Oct 2016

Role Of Students’ Participation On Learning Physics In Active Learning Classes, Binod Nainabasti

FIU Electronic Theses and Dissertations

Students’ interactions can be an influential component of students’ success in an interactive learning environment. From a participation perspective, learning is viewed in terms of how students transform their participation. However, many of the seminal papers discussing the participationist framework are vague on specific details about what student participation really looks like on a fine-grained scale. As part of a large project to understand the role of student participation in learning, this study gathered data that quantified students’ participation in three broad areas of two student-centered introductory calculus-based physics classes structured around the Investigative Science Learning Environment (ISLE) philosophy. These …


Effect Of Void Fraction On Transverse Shear Modulus Of Advanced Unidirectional Composites, Jui-He Tai Oct 2016

Effect Of Void Fraction On Transverse Shear Modulus Of Advanced Unidirectional Composites, Jui-He Tai

USF Tampa Graduate Theses and Dissertations

In composite materials, transverse shear modulus is a critical moduli parameter for designing complex composite structures. For dependable mathematical modeling of mechanical behavior of composite materials, an accurate estimate of the moduli parameters is critically important as opposed to estimates of strength parameters where underestimation may lead to a non-optimal design but still would give one a safe one.

Although there are mechanical and empirical models available to find transverse shear modulus, they are based on many assumptions. In this work, the model is based on a three-dimensional elastic finite element analysis with multiple cells. To find the shear modulus, …


An Analysis Of The Microseismic Peak At Ligo Hanford Observatory, Nathan Sweem Oct 2016

An Analysis Of The Microseismic Peak At Ligo Hanford Observatory, Nathan Sweem

STAR Program Research Presentations

The Laser Interferometer Gravitational-Wave Observatory (LIGO) consists of two facilities, LIGO Hanford Observatory (LHO) and LIGO Livingston Observatory (LLO). Gravitational-wave astronomy began when LIGO observed gravitational-waves for the first time in 2015 during the inaugural observation run (01) of the advanced detector era. Isolation of LIGO detectors from seismic noise is necessary to achieve a desired level of performance. Analysis of seismic noise is essential to make improvements in seismic isolation, and to validate gravitational-wave candidates with a high degree of certainty. Hourly trends of seismic noise in the 0.1 – 0.3 Hz frequency band from Guralp CMG-40T three-axis seismometers …


Photonic Crystals With Alternate Arrays Of Rods And Holes In A Low Dielectric-Index Material, Dimitar L. Dimitrov Sep 2016

Photonic Crystals With Alternate Arrays Of Rods And Holes In A Low Dielectric-Index Material, Dimitar L. Dimitrov

Dissertations, Theses, and Capstone Projects

This thesis theoretically deals with the propagation of electromagnetic waves (light beams) in periodically modulated dielectric material structures based on Maxwell’s equations. We are interested in novel light propagation characteristics in these man-made dielectric material structures for practical applications, especially on optical communications and computations. Since the wavelength range of light is on the same order of magnitude as the modulation periods of dielectric materials, an analogy of the light propagation in dielectric-constant modulated structures with the electron transport in solid-state crystals is used throughout my thesis by using a term “photonic crystals (PhCs)” referring to these dielectric structures. I …


Evolution Of Network Architecture In A Granular Material Under Compression, Lia Papadopoulous, James G. Puckett, Karen E. Daniels, Danielle S. Bassett Sep 2016

Evolution Of Network Architecture In A Granular Material Under Compression, Lia Papadopoulous, James G. Puckett, Karen E. Daniels, Danielle S. Bassett

Physics and Astronomy Faculty Publications

As a granular material is compressed, the particles and forces within the system arrange to form complex and heterogeneous collective structures. Force chains are a prime example of such structures, and are thought to constrain bulk properties such as mechanical stability and acoustic transmission. However, capturing and characterizing the evolving nature of the intrinsic inhomogeneity and mesoscale architecture of granular systems can be challenging. A growing body of work has shown that graph theoretic approaches may provide a useful foundation for tackling these problems. Here, we extend the current approaches by utilizing multilayer networks as a framework for directly quantifying …


Targeting Residential Energy Reduction For City Utilities Using Historical Electrical Utility Data And Readily Available Building Data, Kevin P. Hallinan, J. Kelly Kissock, Robert J. Brecha, Austin Mitchell Sep 2016

Targeting Residential Energy Reduction For City Utilities Using Historical Electrical Utility Data And Readily Available Building Data, Kevin P. Hallinan, J. Kelly Kissock, Robert J. Brecha, Austin Mitchell

J. Kissock

Energy use data for the eight-year period 2003–2010 was analyzed for over 1200 single family residences in Village of Yellow Springs, Ohio. Electricity, natural gas, residential building, and weather databases are merged to permit determination of the energy intensity of each home in the village. The energy use intensity for each home is disaggregated into weather independent and weather dependent electric and natural gas use. This use is compared to typical baseline, cooling, and heating energy use for the region. From this comparison, priority homes are identified for energy reduction investment. Collective potential low cost energy reduction is estimated for …


Prioritizing Investment In Residential Energy Efficiency And Renewable Energy: A Case Study For The U.S. Midwest, Robert J. Brecha, Austin Mitchell, Kevin P. Hallinan, J. Kelly Kissock Sep 2016

Prioritizing Investment In Residential Energy Efficiency And Renewable Energy: A Case Study For The U.S. Midwest, Robert J. Brecha, Austin Mitchell, Kevin P. Hallinan, J. Kelly Kissock

J. Kissock

Residential building energy use is an important contributor to greenhouse gas emissions and in the United States represents about 20% of total energy consumption. A number of previous macro-scale studies of residential energy consumption and energy-efficiency improvements are mainly concerned with national or international aggregate potential savings. In this paper we look into the details of how a collection of specific homes in one region might reduce energy consumption and carbon emissions, with particular attention given to some practical limits to what can be achieved by upgrading the existing residential building stock. Using a simple model of residential, single-family home …


Optimization-Free Optical Focal Field Engineering Through Reversing The Radiation Pattern From A Uniform Line Source, Yanzhong Yu, Qiwen Zhan Sep 2016

Optimization-Free Optical Focal Field Engineering Through Reversing The Radiation Pattern From A Uniform Line Source, Yanzhong Yu, Qiwen Zhan

Qiwen Zhan

A simple and flexible method is presented for the generation of optical focal field with prescribed characteristics. By reversing the field pattern radiated from a uniform line source, for which the electric current is constant along its extent, situated at the focus of a 4Pi focusing system formed by two confocal high-NA objective lenses, the required illumination distribution at the pupil plane for creating optical focal field with desired properties can be obtained. Numerical example shows that an arbitrary length optical needle with extremely high longitudinal polarization purity and consistent transverse size of ~0.36λ over the entire depth of focus …


Tailoring Optical Complex Fields With Nano-Metallic Surfaces, Guanghao Rui, Qiwen Zhan Sep 2016

Tailoring Optical Complex Fields With Nano-Metallic Surfaces, Guanghao Rui, Qiwen Zhan

Qiwen Zhan

Recently there is an increasing interest in complex optical fields with spatially inhomogeneous state of polarizations and optical singularities. Novel effects and phenomena have been predicted and observed for light beams with these unconventional states. Nanostructured metallic thin film offers unique opportunities to generate, manipulate and detect these novel fields. Strong interactions between nano-metallic surfaces and complex optical fields enable the development of highly compact and versatile functional devices and systems. In this review, we first briefly summarize the recent developments in complex optical fields. Various nano-metallic surface designs that can produce and manipulate complex optical fields with tailored characteristics …


Creation Of Identical Multiple Focal Spots With Prescribed Axial Distribution, Yanzhong Yu, Qiwen Zhan Sep 2016

Creation Of Identical Multiple Focal Spots With Prescribed Axial Distribution, Yanzhong Yu, Qiwen Zhan

Qiwen Zhan

We present a scheme for the construction of coaxially equidistant multiple focal spots with identical intensity profiles for each individual focus and a predetermined number and spacing. To achieve this, the radiation field from an antenna is reversed and then gathered by high numerical aperture objective lenses. Radiation patterns from three types of line sources, i.e., the electric current, magnetic current and electromagnetic current distributions, with cosine-squared taper are respectively employed to generate predominately longitudinally polarized bright spots, azimuthally polarized doughnuts, and focal spots with a perfect spherically symmetric intensity distribution. The required illuminations at the pupil plane of a …


Digital Image Processing, Russell C. Hardie, Majeed M. Hayat Sep 2016

Digital Image Processing, Russell C. Hardie, Majeed M. Hayat

Russell C. Hardie

In recent years, digital images and digital image processing have become part of everyday life. This growth has been primarily fueled by advances in digital computers and the advent and growth of the Internet. Furthermore, commercially available digital cameras, scanners, and other equipment for acquiring, storing, and displaying digital imagery have become very inexpensive and increasingly powerful. An excellent treatment of digital images and digital image processing can be found in Ref. [1]. A digital image is simply a two-dimensional array of finite-precision numerical values called picture elements (or pixels). Thus a digital image is a spatially discrete (or discrete-space) …


A Clean Energy Utility For Multifamily Housing In A Deregulated Energy Market, Ata Raziei, Kevin P. Hallinan, Robert J. Brecha Sep 2016

A Clean Energy Utility For Multifamily Housing In A Deregulated Energy Market, Ata Raziei, Kevin P. Hallinan, Robert J. Brecha

Physics Faculty Publications

Energy efficiency and renewable energy (EERE) investment in multifamily residences in the United States has not kept pace with investment in resident-owned facilities. Split incentives, where owners cannot benefit economically from energy cost savings for residences and resident investment in EERE is not feasible, have posed a significant barrier. A clean energy utility is posited to circumvent this barrier. This utility would be responsible for power purchase from the grid, ideally as a real-time purchase agent from the grid manager; investment in energy efficiency and renewable energy; and demand management through control of water heating, as well as supply-side management …


Satellite-Beacon Ionospheric-Scintillation Global Model Of The Upper Atmosphere (Sigma) Ii: Inverse Modeling With High Latitude Observations To Deduce Irregularity Physics, K. B. Deshpande, G. S. Bust, C. R. Clauer, W. A. Scales, N. A. Frissell, J. M. Ruohoniemi, L. Spogli, C. Mitchell, Allan T. Weatherwax Sep 2016

Satellite-Beacon Ionospheric-Scintillation Global Model Of The Upper Atmosphere (Sigma) Ii: Inverse Modeling With High Latitude Observations To Deduce Irregularity Physics, K. B. Deshpande, G. S. Bust, C. R. Clauer, W. A. Scales, N. A. Frissell, J. M. Ruohoniemi, L. Spogli, C. Mitchell, Allan T. Weatherwax

Physics Faculty Publications

Ionospheric scintillation is caused by irregularities in the ionospheric electron density. The characterization of ionospheric irregularities is important to further our understanding of the underlying physics. Our goal is to characterize the intermediate (0.1–10 km) to medium (10–100 km) scale high-latitude irregularities which are likely to produce these scintillations. In this paper, we characterize irregularities observed by Global Navigation Satellite System (GNSS) during a geomagnetically active period on 9 March 2012. For this purpose, along with the measurements, we are using the recently developed model: “Satellite-beacon Ionospheric-scintillation Global Model of the upper Atmosphere” (SIGMA). The model is particularly applicable at …


Magnetism In Curved Geometries, Robert Streubel, Peter Fischer, Florian Kronast, Volodymyr P. Kravchuk, Denis D. Sheka, Yuri Gaididei, Oliver G. Schmidt, Denys Makarov Aug 2016

Magnetism In Curved Geometries, Robert Streubel, Peter Fischer, Florian Kronast, Volodymyr P. Kravchuk, Denis D. Sheka, Yuri Gaididei, Oliver G. Schmidt, Denys Makarov

Robert Streubel Papers

Extending planar two-dimensional structures into the three-dimensional space has become a general trend in multiple disciplines, including electronics, photonics, plasmonics and magnetics. This approach provides means to modify conventional or to launch novel functionalities by tailoring the geometry of an object, e.g. its local curvature. In a generic electronic system, curvature results in the appearance of scalar and vector geometric potentials inducing anisotropic and chiral effects. In the specific case of magnetism, even in the simplest case of a curved anisotropic Heisenberg magnet, the curvilinear geometry manifests two exchange-driven interactions, namely effective anisotropy and antisymmetric exchange, i.e. Dzyaloshinskii-Moriya-like interaction. As …


3d Post-Stack Seismic Inversion Using Global Optimization Techniques: Gulf Of Mexico Example, Elijah A. Adedeji Aug 2016

3d Post-Stack Seismic Inversion Using Global Optimization Techniques: Gulf Of Mexico Example, Elijah A. Adedeji

University of New Orleans Theses and Dissertations

Seismic inversion using a global optimization algorithm is a non-linear, model-driven process. It yields an optimal solution of the cost function – reflectivity/acoustic impedance, when prior information is sparse. The inversion result offers detailed interpretations of thin layers, internal stratigraphy, and lateral continuity and connectivity of sand bodies. This study compared two stable and robust global optimization techniques, Simulated Annealing (SA) and Basis Pursuit Inversion (BPI) as applied to post-stack seismic data from the Gulf of Mexico.

Both methods use different routines and constraints to search for the minimum error energy function. Estimation of inversion parameters in SA is rigorous …


Developing Hyperpolarized Silicon Particles For In Vivo Mri Targeting Of Ovarian Cancer, Nicholas Whiting, Jingzhe Hu, Niki M. Zacharias, Ganesh L. R. Lokesh, David E. Volk, David G. Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K. Sood, Pratip Bhattacharya Aug 2016

Developing Hyperpolarized Silicon Particles For In Vivo Mri Targeting Of Ovarian Cancer, Nicholas Whiting, Jingzhe Hu, Niki M. Zacharias, Ganesh L. R. Lokesh, David E. Volk, David G. Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K. Sood, Pratip Bhattacharya

Nicholas Whiting

Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging. The enhanced spin polarization of silicon lasts significantly longer than other hyperpolarized agents (tens of minutes, whereas <1  min for other species at room temperature), allowing a wide range of potential …