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Articles 1 - 4 of 4
Full-Text Articles in Biological and Chemical Physics
Functional And Structural Studies Of Cytochromes P450 By Resonance Raman Spectroscopy, Yilin Liu
Functional And Structural Studies Of Cytochromes P450 By Resonance Raman Spectroscopy, Yilin Liu
Dissertations (1934 -)
Cytochrome P450 is a broad class of heme monooxygenase enzymes which catalyze various oxidative transformations. There are two main kinds of mammalian P450s: steroidogenic and drug metabolizing P450s. The first project involves a steroidogenic P450, CYP17A1, occupying a central role in the biosynthesis of steroid hormones. It catalyzes hydroxylation reaction on pregnenolone and progesterone, generating 17OH-pregnenolone and 17OH-progesterone, presumably utilizing a “Compound I” species. However, these hydroxylated products can be further processed in a second oxidative cycle to cleave the C17–C20 bond to form dehydroepiandrosterone or androstenedione, respectively, a crucial step in androgen production. Interestingly, it is well known that …
C.V. - Wojciech Budzianowski, Wojciech M. Budzianowski
Renewable Energy And Sustainable Development (Resd) Group, Wojciech M. Budzianowski
Renewable Energy And Sustainable Development (Resd) Group, Wojciech M. Budzianowski
Wojciech Budzianowski
No abstract provided.
Design And Activation Of Frequency Tunable 200ghz Gyrotron, Natalie Golota, Faith Scott, Edward Saliba, Brice Albert, Alexander Barnes
Design And Activation Of Frequency Tunable 200ghz Gyrotron, Natalie Golota, Faith Scott, Edward Saliba, Brice Albert, Alexander Barnes
Undergraduate Research Symposium Posters
Dynamic Nuclear Polarization (DNP) when combined with Nuclear Magnetic Resonance (NMR) yields high sensitivity spectra while decreasing sample acquisition time. DNP transfers polarization from electron to nuclear spins, giving a strong enhancement of NMR signal. DNP is rapidly developing area of research due in part to application of cyclotron resonance masers (gyrotron) as high power microwave sources. Gyrotrons provide a high-power, high-frequency microwave source that can be used in close proximity to high field NMR magnets. Gyrotrons are operated under strong vacuum and within a cryogenic superconducting magnetic. Gyrotron microwave power is generated by a magnetron injection gun (MIG) composed …