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Supertertiary Structural Dynamics Modulate Function In Postsynaptic Density Protein 95, George L. Hamilton Iii May 2022

Supertertiary Structural Dynamics Modulate Function In Postsynaptic Density Protein 95, George L. Hamilton Iii

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Proteins, RNA, and DNA serve as the primary sub-cellular machinery that give rise to the necessary functions of life. The long-standing paradigm has been that the structures of biomolecules, or the arrangement of the subunits that make up a biomolecule, determine biological function. However, biomolecules are not static objects. Instead, they often undergo structural rearrangements that are crucial to enabling and regulating their functions. In my thesis I present several studies of the interplay between the structures, dynamics, and functions of biomolecules that combine experimental fluorescence spectroscopy and computational methods to probe these systems at the single-molecule level. In particular, …


Iron Abundances And Atmospheric Parameters Of Red Giants In The Open Cluster Ic 4756, Julie Djordjevic Aug 2013

Iron Abundances And Atmospheric Parameters Of Red Giants In The Open Cluster Ic 4756, Julie Djordjevic

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Three red giants were investigated within the open cluster IC 4756 using observations taken from the McDonald Observatory's 2.1m Otto Struve Telescope and the Sandiford Cassegrain Echelle Spectrometer (SES). Iron abundances were calculated for each star based on the equivalent widths of Fe I and Fe II lines measured using the line lists of Bubar and King (2010) and Schuler et al. (2005). Also derived were the basic atmospheric parameters: effective temperature, surface gravity, metallicity, and microturbulence. Her 35, Her 85, and Her 249 were found to have corresponding [Fe I/H] of 0.06 ± 0.04, -0.16 ± 0.03, and -0.16 …