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Articles 1 - 5 of 5
Full-Text Articles in Physics
Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar
Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar
Journal of Wellness
The essential question of the relationship between consciousness and matter is ignored in medical school curricula, leading to a machine-like view of the human being that contributes to physician burnout and intellectual dissatisfaction. The evidence suggesting that the brain may not be the seat of consciousness is generally ignored to preserve the worldview of the primacy of matter. By investigating new frameworks detailing the nature of consciousness at different levels of hierarchy, we can bring intellectual rigor to a once opaque subject that supports a fundamental reality about our experience: We are human beings, not only human bodies.
Serotonergic Axons As Fractional Brownian Motion Paths: Insights Into The Self-Organization Of Regional Densities, Skirmantas Janusonis, Nils Detering, Ralf Metzler, Thomas Vojta
Serotonergic Axons As Fractional Brownian Motion Paths: Insights Into The Self-Organization Of Regional Densities, Skirmantas Janusonis, Nils Detering, Ralf Metzler, Thomas Vojta
Physics Faculty Research & Creative Works
All vertebrate brains contain a dense matrix of thin fibers that release serotonin (5-hydroxytryptamine), a neurotransmitter that modulates a wide range of neural, glial, and vascular processes. Perturbations in the density of this matrix have been associated with a number of mental disorders, including autism and depression, but its self-organization and plasticity remain poorly understood. We introduce a model based on reflected Fractional Brownian Motion (FBM), a rigorously defined stochastic process, and show that it recapitulates some key features of regional serotonergic fiber densities. Specifically, we use supercomputing simulations to model fibers as FBM-paths in two-dimensional brain-like domains and demonstrate …
Resting-State Connectivity Dynamics In The Human Brain Using High-Speed Fmri, Kishore Vakamudi
Resting-State Connectivity Dynamics In The Human Brain Using High-Speed Fmri, Kishore Vakamudi
Physics & Astronomy ETDs
Resting-state fMRI using seed-based connectivity analysis (SCA) typically involves regression of the confounding signals resulting from movement and physiological noise sources. This not only adds additional complexity to the analysis but may also introduce possible regression bias. We recently introduced a computationally efficient real-time SCA approach without confound regression, which employs sliding-window correlation analysis with running mean and standard deviation (meta-statistics). The present study characterizes the confound tolerance of this windowed seed-based connectivity analysis (wSCA), which combines efficient decorrelation of confounding signal events with high-pass filter characteristics that reduce sensitivity to drifts. The confound suppression and the strength of resting-state …
Characterization Of Cellular Uptake And Toxicity Of Aminosilane-Coated Iron Oxide Nanoparticles With Different Charges In Central Nervous System-Relevant Cell Culture Models, Zhizhi Sun, Vinith Yathindranath, Matthew Worden, James A. Thliveris, Stephanie Chu, Fiona E. Parkinson, Torsten Hegmann, Donald W. Miller
Characterization Of Cellular Uptake And Toxicity Of Aminosilane-Coated Iron Oxide Nanoparticles With Different Charges In Central Nervous System-Relevant Cell Culture Models, Zhizhi Sun, Vinith Yathindranath, Matthew Worden, James A. Thliveris, Stephanie Chu, Fiona E. Parkinson, Torsten Hegmann, Donald W. Miller
Torsten Hegmann
Background: Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.
Monte Carlo Simulation Of The Spatial Resolution And Depth Sensitivity Of Two-Dimensional Optical Imaging Of The Brain, Peifang Tian, Anna Devor, Sara Sakadžić, Anders Dale, David Boas
Monte Carlo Simulation Of The Spatial Resolution And Depth Sensitivity Of Two-Dimensional Optical Imaging Of The Brain, Peifang Tian, Anna Devor, Sara Sakadžić, Anders Dale, David Boas
Peifang Tian
Absorption or fluorescence-based two-dimensional (2-D) optical imaging is widely employed in functional brain imaging. The image is a weighted sum of the real signal from the tissue at different depths. This weighting function is defined as “depth sensitivity.” Characterizing depth sensitivity and spatial resolution is important to better interpret the functional imaging data. However, due to light scattering and absorption in biological tissues, our knowledge of these is incomplete. We use Monte Carlo simulations to carry out a systematic study of spatial resolution and depth sensitivity for 2-D optical imaging methods with configurations typically encountered in functional brain imaging. We …