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Articles 1 - 22 of 22
Full-Text Articles in Physics
Mode-Sum Prescription For The Vacuum Polarization In Odd Dimensions, Peter Taylor, Cormac Breen
Mode-Sum Prescription For The Vacuum Polarization In Odd Dimensions, Peter Taylor, Cormac Breen
Articles
We present a new mode-sum regularization prescription for computing the vacuum polarization of a scalar field in static spherically-symmetric black hole spacetimes in odd dimensions. This is the first general and systematic approach to regularized vacuum polarization in higher dimensions. Remarkably, the regularization parameters can be computed in closed form in arbitrary dimensions and for arbitrary metric function $f(r)$. In fact, we show that in spite of the increasing severity and number of the divergences to be regularized, the method presented is mostly agnostic to the number of dimensions. Finally, as an explicit example of our method, we show plots …
Ultra-Filtration Of Human Serum For Improved Quantitative Analysis Of Low Molecular Weight Biomarkers Using Atr-Ir Spectroscopy, Franck Bonnier, Helene Blasco, Clement Wasselet, Guillaume Brachet, Renaud Respaud, Luis Felipe Cs. Carvalho, Dominque Bertrand, Mathew J. Baker, Hugh Byrne, Igor Chourpa
Ultra-Filtration Of Human Serum For Improved Quantitative Analysis Of Low Molecular Weight Biomarkers Using Atr-Ir Spectroscopy, Franck Bonnier, Helene Blasco, Clement Wasselet, Guillaume Brachet, Renaud Respaud, Luis Felipe Cs. Carvalho, Dominque Bertrand, Mathew J. Baker, Hugh Byrne, Igor Chourpa
Articles
Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering a molecular finger print of the sample. It is expected that its sensitivity would enable detection of small chemical variations in biological samples associated with disease. ATR-IR is particularly suitable for liquid sample analysis and, although air drying is commonly performed before data collection, just a drop of human serum is enough for screening and early diagnosis. However, the dynamic range of constituent biochemical concentrations in the serum composition remains a limiting factor to the reliability of the technique. Using glucose as a model spike in human serum, …
In Vitro Monitoring Of Time And Dose Dependent Cytotoxicity Of Aminated Nanoparticles Using Raman Spectroscopy, Esen Efeoglu, Alan Casey, Hugh Byrne
In Vitro Monitoring Of Time And Dose Dependent Cytotoxicity Of Aminated Nanoparticles Using Raman Spectroscopy, Esen Efeoglu, Alan Casey, Hugh Byrne
Articles
No abstract provided.
Spectroscopic Studies Of Anthracyclines: Structural Characterization And In Vitro Tracking, Zeineb Farhane, Hugh Byrne, Malgorzata Baranska
Spectroscopic Studies Of Anthracyclines: Structural Characterization And In Vitro Tracking, Zeineb Farhane, Hugh Byrne, Malgorzata Baranska
Articles
A broad spectroscopic characterization, using ultraviolet-visible (UV-vis) and Fourier transform infrared absorption as well as Raman scattering, of two commonly used anthracyclines antibiotics (DOX) daunorubicin (DNR), their epimers (EDOX, EDNR) and ten selected analogs is presented. The paper serves as a comprehensive spectral library of UV-vis, IR and Raman spectra of anthracyclines in the solid state and in solution. The particular advantage of Raman spectroscopy for the measurement and analysis of individual antibiotics is demonstrated. Raman spectroscopy can be used to monitor the in vitro uptake and distribution of the drug in cells, using both 488 nm and 785 nm …
A Comparison Of Catabolic Pathways Induced In Primary Macrophages By Pristine Single Walled Carbon Nanotubes And Pristine Graphene, Caroline More, Jennifer Mcintyre, Luke O'Neill, Hugh Byrne
A Comparison Of Catabolic Pathways Induced In Primary Macrophages By Pristine Single Walled Carbon Nanotubes And Pristine Graphene, Caroline More, Jennifer Mcintyre, Luke O'Neill, Hugh Byrne
Articles
Understanding the correlation between the physico-chemical properties of carbonaceous nanomaterials and how these properties impact on cells and subcelluar mechanisms is critical to their risk assessment and safe translation into newly engineered devices. Here the toxicity, uptake and catabolic response of primary human macrophages to pristine graphene (PG) and pristine single walled carbon nanotubes (pSWCNT) are explored, compared and contrasted. The nanomaterial toxicity was assessed using three complementary techniques (live-dead assay, real time impedance technique and confocal microscopic analysis), all of which indicated no signs of acute cytotoxicity in response to PG or pSWCNT. Transmission electron microscopy (TEM) demonstrated that …
The Evaluation And Implementation Of Magnetic Fields For Large Strain Uniaxial And Biaxial Cyclic Testing Of Magnetorheological Elastomers., Dave Gorman, Niall Murphy, Ray Ekins, Stephen Jerrams
The Evaluation And Implementation Of Magnetic Fields For Large Strain Uniaxial And Biaxial Cyclic Testing Of Magnetorheological Elastomers., Dave Gorman, Niall Murphy, Ray Ekins, Stephen Jerrams
Articles
Magnetorheological Elastomers (MREs) are “smart” materials whose physical properties are altered by the application of magnetic fields. In previous studies the properties of MREs have been evaluated under a variety of conditions, however little attention has been paid to the recording and reporting of the magnetic fields used in these tests [1]. Currently there is no standard accepted method for specifying the magnetic field applied during MRE testing. This study presents a detailed map of a magnetic field applied during MRE tests as well as providing the first comparative results for uniaxial and biaxial testing under high strain fatigue test …
Theoretical Modeling Of The Effect Of Polymer Chain Immobilization Rates On Holographic Recording In Photopolymers, Dana Mackey, Paul O'Reilly, Izabela Naydenova
Theoretical Modeling Of The Effect Of Polymer Chain Immobilization Rates On Holographic Recording In Photopolymers, Dana Mackey, Paul O'Reilly, Izabela Naydenova
Articles
This paper introduces an improved mathematical model for holographic grating formation in an acrylamide-based photopolymer, which consists of partial differential equations derived from physical laws. The model is based on the two-way diffusion theory of \cite{izabela}, which assumes short polymer chains are free to diffuse, and generalizes a similar model presented in \cite{josab} by introducing an immobilization rate governed by chain growth and cross-linking. Numerical simulations were carried out in order to investigate the behaviour of the photopolymer system for short and long exposures, with particular emphasis on the effect of recording parameters (such as illumination frequency and intensity), as …
Evaluation Of Cytotoxicity Profile And Intracellular Localisation Of Doxorubicin-Loaded Chitosan Nanoparticles, Gabriele Dadalt Souto, Zeineb Farhane, Esen Efeoglu, Alan Casey, Jennifer Mcintyre, Hugh Byrne
Evaluation Of Cytotoxicity Profile And Intracellular Localisation Of Doxorubicin-Loaded Chitosan Nanoparticles, Gabriele Dadalt Souto, Zeineb Farhane, Esen Efeoglu, Alan Casey, Jennifer Mcintyre, Hugh Byrne
Articles
In the emerging field of nanomedicine, targeted delivery of nanoparticle encapsulated active pharmaceutical ingredients (API) is seen as a potential significant development, promising improved pharmacokinetics and reduced side effects. In this context, understanding the cellular uptake of the nanoparticles and subsequent subcellular distribution of the API is of critical importance. Doxorubicin (DOX) was encapsulated within chitosan nanoparticles to investigate its intracellular delivery in A549 cells in vitro. Unloaded (CS-TPP) and doxorubicin-loaded (DOX-CS-TPP) chitosan nanoparticles were characterised for size (473±41 nm), polydispersity index (0.3±0.2), zeta potential (34±4 mV), drug content (76±7 µM) and encapsulation efficiency (95±1%). The cytotoxic response to …
Modification Of The In Vitro Uptake Mechanism And Anti-Oxidant Levels In Hacat Cells And Resultant Changes To Toxicity And Oxidative Stress Of G4 And G6 Poly (Amido Amine) Dendrimer Nanoparticles, Marcus A. Maher, Hugh Byrne
Modification Of The In Vitro Uptake Mechanism And Anti-Oxidant Levels In Hacat Cells And Resultant Changes To Toxicity And Oxidative Stress Of G4 And G6 Poly (Amido Amine) Dendrimer Nanoparticles, Marcus A. Maher, Hugh Byrne
Articles
The mechanism of cellular uptake by endocytosis and subsequent oxidative stress has been identified as the paradigm for the toxic response of cationically surface charged nanoparticles. In an attempt to circumvent the process, the effect of increased cellular membrane permeability on the uptake mechanisms of poly (amidoamine) dendrimers generation 4 (G4) and 6 (G6) in vitro was investigated. Immortalised, non-cancerous human keratinocyte (HaCaT) cells were treated with DL-Buthionine-(S,R)-sulfoximine (BSO). Active uptake of the particles was monitored using fluorescence microscopy to identify and quantify endosomal activity and resultant oxidative stress, manifest as increased levels of reactive oxygen species, monitored using the …
Chemotherapeutic Efficiency Of Drugs In Vitro: Comparison Of Doxorubicin Exposure In 3d And 2d Culture Matrices, Alan Casey, Mahmoud Gargotti, Franck Bonnier, Hugh Byrne
Chemotherapeutic Efficiency Of Drugs In Vitro: Comparison Of Doxorubicin Exposure In 3d And 2d Culture Matrices, Alan Casey, Mahmoud Gargotti, Franck Bonnier, Hugh Byrne
Articles
The interest in the use of 3D matrices for in vitro analysis, with a view to increasing the relevance of in vitro studies and reducing the dependence on in vivo studies, has been growing in recent years. Cells grown in a 3D in vitro matrix environment have been reported to exhibit significantly different properties to those in a conventional 2D culture environment. However, comparison of 2D and 3D cell culture models have recently been noted to result in differing responses of cytotoxic assays, without any associated change in viability. The effect was attributed to differing conversion rates and effective concentrations …
Recent Advances In Optical Diagnosis Of Oral Cancers: Review And Future Perspectives, Ola Ibrahim, Hugh Byrne, Fiona Lyng, Surya Singh, Jopi Mikkonen, Arto Koistinen, Arja Kullaa
Recent Advances In Optical Diagnosis Of Oral Cancers: Review And Future Perspectives, Ola Ibrahim, Hugh Byrne, Fiona Lyng, Surya Singh, Jopi Mikkonen, Arto Koistinen, Arja Kullaa
Articles
Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed and cost, and these label-free, non-invasive methods have the potential to change the future work-flow of cancer management. The oral cavity is particularly accessible and thus such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. Following an introduction to the epidemiology and aetiological factors associated with oral cancers currently employed diagnostic methods and their limitations are presented. …
Spectral Pre And Post Processing For Infrared And Raman Spectroscopy Of Biological Tissues And Cells, Hugh Byrne, Peter Knief, Mark Keating, Franck Bonnier
Spectral Pre And Post Processing For Infrared And Raman Spectroscopy Of Biological Tissues And Cells, Hugh Byrne, Peter Knief, Mark Keating, Franck Bonnier
Articles
Vibrational Spectroscopy, both infrared absorption and Raman spectroscopy, have attracted increasing attention for biomedical applications, from in vivo and ex vivo disease diagnostics and screening, to in vitro screening of therapeutics. There remain, however, many challenges related to the accuracy of analysis of physically and chemically inhomogeneous samples, across heterogeneous sample sets. Data preprocessing is required to deal with variations in instrumental responses and intrinsic spectral backgrounds and distortions in order to extract reliable spectral data. Data postprocessing is required to extract the most reliable information from the sample sets, based on often very subtle changes in spectra associated with …
Acellular Reactivity Of Polymeric Dendrimer Nanoparticles As An Indicator Of Oxidative Stress In Vitro, Marcus Maher, Humza Khalid, Hugh Byrne
Acellular Reactivity Of Polymeric Dendrimer Nanoparticles As An Indicator Of Oxidative Stress In Vitro, Marcus Maher, Humza Khalid, Hugh Byrne
Articles
The need for rapid and cost effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as a primary source of the toxic response suggests the development of acellular assays to screen for nanoparticle surface reactivity. This study explores the potential of the monoamine oxidase A (MAO-A) enzyme based assay with polymeric dendrimers as cofactors and serotonin as substrate, which generates H2O2, quantified by the conversion of the Carboxy-H2DCFDA dye …
Structural Dependence Of The In Vitro Cytotoxicity, Oxidative Stress And Uptake Mechanisms Of Poly(Propylene Imine) Dendritic Nanoparticles, Humza Khalid, Sourav Prasanna Mukherjee, Luke O'Neill, Hugh Byrne
Structural Dependence Of The In Vitro Cytotoxicity, Oxidative Stress And Uptake Mechanisms Of Poly(Propylene Imine) Dendritic Nanoparticles, Humza Khalid, Sourav Prasanna Mukherjee, Luke O'Neill, Hugh Byrne
Articles
The in vitro cytotoxic and intracellular oxidative stress responses to exposure to poly (propylene imine) (PPI) dendritic nanoparticles of increasing generation (number of repeated branching cycles) (G0-G4) were assessed in an immortal non-cancerous human keratinocyte cell-line (HaCaT). Confocal fluorescence microscopy with organelle staining was used to explore the uptake and intracellular trafficking mechanisms. A generation and dose dependent cytotoxic response was observed, increasing according to generation and therefore number of surface amino groups. A comparison of the cytotoxic response of G4 PPI and the related G4 Poly (amido amine) dendrimer indicates that the PPI with the same number of surface …
Screening For Peripheral Arterial Disease And Carotid Artery Disease In Patients With Abdominal Aortic Aneurysm, Cleona Gray, Patrick J. Goodman, Paul Cullen, Stephen Badger, Kevin O'Malley, Martin K. O'Donohoe, Ciarán O. Mcdonnell
Screening For Peripheral Arterial Disease And Carotid Artery Disease In Patients With Abdominal Aortic Aneurysm, Cleona Gray, Patrick J. Goodman, Paul Cullen, Stephen Badger, Kevin O'Malley, Martin K. O'Donohoe, Ciarán O. Mcdonnell
Articles
Screening for concomitant atherosclerotic disease is important in cardiovascular risk reduction. This study assessed the prevalence of carotid artery disease (CAD) and peripheral arterial disease (PAD) in patients with known abdominal aortic aneurysms (AAAs). All patients with AAA attending the vascular laboratory between the January 1, 2007, and December 31, 2009, were eligible for a carotid ultrasound and measurement of ankle brachial indices. A total of 389 (305 males) patients were identified on the AAA surveillance program with a mean (±standard deviation) age of 76 (±8) years. The mean age of the males was 75.4 (±7.8) years, and the mean …
Investigation Of A Scalable Barrel Atmospheric Plasma Reactor For The Treatment Of Polymer Particles, Hisham Abourayana, Vladimir Milosavljevic, Peter Dobbyn, Patrick J. Cullen, Denis Dowling
Investigation Of A Scalable Barrel Atmospheric Plasma Reactor For The Treatment Of Polymer Particles, Hisham Abourayana, Vladimir Milosavljevic, Peter Dobbyn, Patrick J. Cullen, Denis Dowling
Articles
This study reports on the performance of a scalable barrel atmospheric plasma system for the treatment of polymer particles. A novel feature of the barrel system design is the use of a biased electrode, which also acts as the roller for the glass barrel. The plasma is generated using either helium or helium / oxygen gas mixtures. The reactor was used to activate 20 g batches of silicone, polypropylene (PP), acrylonitrile butadiene styrene (ABS) and polyethylene terephthalate (PET) particles, each with diameters in the range 3 to 5 mm. The effect of plasma treatment time and gas flow rate on …
Endovascular Aneurysm Repair Increases Aortic Arterial Stiffness When Compared To Open Repair Of Abdominal Aortic Aneurysms, Cleona Gray, Patrick J. Goodman, Stephen Badger, M. Kevin O'Malley, Martin K. O'Donohoe, Ciarán O. Mcdonnell
Endovascular Aneurysm Repair Increases Aortic Arterial Stiffness When Compared To Open Repair Of Abdominal Aortic Aneurysms, Cleona Gray, Patrick J. Goodman, Stephen Badger, M. Kevin O'Malley, Martin K. O'Donohoe, Ciarán O. Mcdonnell
Articles
Objectives: The initial survival advantage seen with endovascular aneurysm repair (EVAR) over open repair does not persist in the long term. Pulse wave velocity (PWV) is a measure of arterial stiffness, and increased PWV is an independent risk factor for increased cardiovascular morbidity and mortality. This prospective comparative pilot study examined the effect of implantation of an aortic graft on PWV in patients undergoing open or endovascular aortic aneurysm repair. Patients and Methods: Thirty-four patients (15 open and 19 EVAR) were recruited. Patient demographics were similar in both the groups. Pulse wave velocity was calculated for all patients …
A Novel Anthropomorphic Flow Phantom For The Quantitative Evaluation Of Prostate Dce-Mri Acquisition Techniques, Silvin Knight, Jacinta Browne, James Meaney, David Smith, Andrew Fagan
A Novel Anthropomorphic Flow Phantom For The Quantitative Evaluation Of Prostate Dce-Mri Acquisition Techniques, Silvin Knight, Jacinta Browne, James Meaney, David Smith, Andrew Fagan
Articles
A novel anthropomorphic flow phantom device has been developed which can be used for quantitatively assessing the ability of MRI scanners to accurately measure signal / concentration time-intensity curves (CTCs) associated with dynamic contrast-enhanced (DCE) MRI. Modelling of the complex pharmacokinetics of contrast agents as they perfuse through the tumour capillary network has shown great promise for cancer diagnosis and therapy monitoring. However, clinical adoption has been hindered by methodological problems, resulting in a lack of consensus regarding the most appropriate acquisition and modelling methodology to use and a consequent wide discrepancy in published data. A heretofore overlooked source of …
The Dynamics Of Flat Surface Internal Geophysical Waves With Currents, Alan Compelli, Rossen Ivanov
The Dynamics Of Flat Surface Internal Geophysical Waves With Currents, Alan Compelli, Rossen Ivanov
Articles
A two-dimensional water wave system is examined consisting of two discrete incompressible fluid domains separated by a free common interface. In a geophysical context this is a model of an internal wave, formed at a pycnocline or thermocline in the ocean. The system is considered as being bounded at the bottom and top by a flatbed and wave-free surface respectively. A current profile with depth-dependent currents in each domain is considered. The Hamiltonian of the system is determined and expressed in terms of canonical wave-related variables. Limiting behavior is examined and compared to that of other known models. The linearised …
Investigating Alaskan Methane And Carbon Dioxide Fluxes Using Measurements From The Carve Tower, Anna Karion, Colm Sweeney Colm Sweeney, John B. Miller John B. Miller, Arlyn E. Andrews, Roisin Commane, Steven Dinardo, John M. Henderson, Jacob Lindaas, John C. Lin, Kristina Luus, Tim Newberger, Pieter Tans Pieter Tans, Steven C. Wofsy, Sonja Wolter, Charles E. Miller
Investigating Alaskan Methane And Carbon Dioxide Fluxes Using Measurements From The Carve Tower, Anna Karion, Colm Sweeney Colm Sweeney, John B. Miller John B. Miller, Arlyn E. Andrews, Roisin Commane, Steven Dinardo, John M. Henderson, Jacob Lindaas, John C. Lin, Kristina Luus, Tim Newberger, Pieter Tans Pieter Tans, Steven C. Wofsy, Sonja Wolter, Charles E. Miller
Articles
Northern high-latitude carbon sources and sinks, including those resulting from degrading permafrost, are thought to be sensitive to the rapidly warming climate. Because the near-surface atmosphere integrates surface fluxes over large ( ∼ 500–1000 km) scales, atmospheric monitoring of carbon dioxide (CO2) and methane (CH4) mole fractions in the daytime mixed layer is a promising method for detecting change in the carbon cycle throughout boreal Alaska. Here we use CO2 and CH4 measurements from a NOAA tower 17 km north of Fairbanks, AK, established as part of NASA's Carbon in Arctic Reservoirs Vulnerability Experiment (CARVE), to investigate regional fluxes of …
Controllable Growth Of Vertically Aligned Graphene On C-Face Sic, Yu Liu, Lianlian Chen, Hilliard Hilliard, Qing-Song Huang, Fang Liu, Mao Wang, Roman Böttger, René Hübner, Alpha T. N’Diaye, Elke Arenholz Elke Arenholz, Viton Heera Viton Heera, Wolfgang Skorupa Wolfgang Skorupa, Shengqiang Zhou
Controllable Growth Of Vertically Aligned Graphene On C-Face Sic, Yu Liu, Lianlian Chen, Hilliard Hilliard, Qing-Song Huang, Fang Liu, Mao Wang, Roman Böttger, René Hübner, Alpha T. N’Diaye, Elke Arenholz Elke Arenholz, Viton Heera Viton Heera, Wolfgang Skorupa Wolfgang Skorupa, Shengqiang Zhou
Articles
We investigated how to control the growth of vertically aligned graphene on C-face SiC by varying the processing conditions. It is found that, the growth rate scales with the annealing temperature and the graphene height is proportional to the annealing time. Temperature gradient and crystalline quality of the SiC substrates influence their vaporization. The partial vapor pressure is crucial as it can interfere with further vaporization. A growth mechanism is proposed in terms of physical vapor transport. The monolayer character of vertically aligned graphene is verified by Raman and X-ray absorption spectroscopy. With the processed samples, d0 magnetism is realized …
Characterisation Of Strip Silicon Detectors For The Atlas Phase-Ii Upgrade With A Micro-Focused X-Ray Beam, L. Poley, A. Blue, R. Bates, I. Bloch, S. Diez, J. Fernandez-Tejero, C. Fleta, B. Gallop, B. Greenall, I.M. Gregor, K. Hara, Y. Ikegami, C. Lacasta, K. Lohwasser, D. Maneuski, S. Nagorski, I. Pape, P.W. Phillips, D. Sperlich, K. Sawhney
Characterisation Of Strip Silicon Detectors For The Atlas Phase-Ii Upgrade With A Micro-Focused X-Ray Beam, L. Poley, A. Blue, R. Bates, I. Bloch, S. Diez, J. Fernandez-Tejero, C. Fleta, B. Gallop, B. Greenall, I.M. Gregor, K. Hara, Y. Ikegami, C. Lacasta, K. Lohwasser, D. Maneuski, S. Nagorski, I. Pape, P.W. Phillips, D. Sperlich, K. Sawhney
Articles
The planned HL-LHC (High Luminosity LHC) in 2025 is being designed to maximise the physics potential through a sizable increase in the luminosity up to 6centerdot1034 cm−2s−1. A consequence of this increased luminosity is the expected radiation damage at 3000 fb−1 after ten years of operation, requiring the tracking detectors to withstand fluences to over 1centerdot1016 1 MeV neq/cm2. In order to cope with the consequent increased readout rates, a complete re-design of the current ATLAS Inner Detector (ID) is being developed as the Inner Tracker (ITk).