Physics Commons^™

Intracellular Signaling: How Do Cells Respond To Single And Multiple Inputs, Latoya Crayton

Honors Capstone Projects - All

One important biological question is how the cell processes input information and decides what to respond. The cell can integrate the multiple inputs using linear and nonlinear dynamics to generate an appropriate output. This study focuses on the computerized recording of phototaxis (movement in relation to light direction) of Chlamydomonas cell populations response to green light, which activates the rhodopsin photoreceptor at their eyespots. The inputs are light stimulation of various wavelengths and intensities; and chemicals (IBMX, a PDE inhibitor; 2'5'-dideoxyadenosine, an adenylate cyclase inhibitor, 8-Br-cAMP-Na and Dibutyryl cAMP, cAMP analogs) affecting an important intracellular messenger, cAMP. The quantified output …