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Full-Text Articles in Physics

Identification Of An Intermediate Species Along The Nitrile Hydratase Reaction Pathway By Epr Spectroscopy, Wasantha Lankathilaka Karunagala Pathiranage, Natalie Gumataotao, Adam T. Fiedler, Richard C. Holz, Brian Bennett Nov 2021

Identification Of An Intermediate Species Along The Nitrile Hydratase Reaction Pathway By Epr Spectroscopy, Wasantha Lankathilaka Karunagala Pathiranage, Natalie Gumataotao, Adam T. Fiedler, Richard C. Holz, Brian Bennett

Physics Faculty Research and Publications

A new method to trap catalytic intermediate species was employed with Fe-type nitrile hydratase from Rhodococcus equi TG328-2 (ReNHase). ReNHase was incubated with substrates in a 23% (w/w) NaCl/H2O eutectic system that remained liquid at −20 °C, thereby permitting the observation of transient species that were present at electron paramagnetic resonance (EPR)-detectable levels in samples frozen while in the steady state. FeIII-EPR signals from the resting enzyme were unaffected by the presence of 23% NaCl, and the catalytic activity was ∼55% that in the absence of NaCl at the optimum pH of 7.5. …


Examination Of The Catalytic Role Of The Axial Cystine Ligand In The Co-Type Nitrile Hydratase From Pseudonocardia Thermophila Jcm 3095, Irene Anyango Ogutu, Martin St. Maurice, Brian Bennett, Richard C. Holz Nov 2021

Examination Of The Catalytic Role Of The Axial Cystine Ligand In The Co-Type Nitrile Hydratase From Pseudonocardia Thermophila Jcm 3095, Irene Anyango Ogutu, Martin St. Maurice, Brian Bennett, Richard C. Holz

Physics Faculty Research and Publications

The strictly conserved αSer162 residue in the Co-type nitrile hydratase from Pseudonocardia thermophila JCM 3095 (PtNHase), which forms a hydrogen bond to the axial αCys108-S atom, was mutated into an Ala residue. The αSer162Ala yielded two different protein species: one was the apoform (αSerA) that exhibited no observable activity, and the second (αSerB) contained its full complement of cobalt ions and was active with a kcat value of 63 ± 3 s−1 towards acrylonitrile at pH 7.5. The X-ray crystal structure of was determined at 1.85 Å resolution and contained no detectable …


Laser Cooling Of Antihydrogen Atoms, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, A. Christensen, R. Collister, A. Cridland Mathad, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, P. Grandemange, P. Granum, J. S. Hangst, W. N. Hardy, M. E. Hayden, D. Hodgkinson, E. D. Hunter, C. A. Isaac, M. A. Johnson, J. M. Jones, S. A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J. T. K. Mckenna, S. Menary, J. M. Michan, T. Momose, P. S. Mullan, K. Olchanski, A. Olin, J. Peszka, A. Powell, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, D, M. Starko, C. So, G. Stutter, Timothy Tharp, A. Thibeault, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele Apr 2021

Laser Cooling Of Antihydrogen Atoms, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, A. Christensen, R. Collister, A. Cridland Mathad, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, P. Grandemange, P. Granum, J. S. Hangst, W. N. Hardy, M. E. Hayden, D. Hodgkinson, E. D. Hunter, C. A. Isaac, M. A. Johnson, J. M. Jones, S. A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J. T. K. Mckenna, S. Menary, J. M. Michan, T. Momose, P. S. Mullan, K. Olchanski, A. Olin, J. Peszka, A. Powell, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, D, M. Starko, C. So, G. Stutter, Timothy Tharp, A. Thibeault, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele

Physics Faculty Research and Publications

The photon—the quantum excitation of the electromagnetic field—is massless but carries momentum. A photon can therefore exert a force on an object upon collision1. Slowing the translational motion of atoms and ions by application of such a force2,3, known as laser cooling, was first demonstrated 40 years ago4,5. It revolutionized atomic physics over the following decades6,7,8, and it is now a workhorse in many fields, including studies on quantum degenerate gases, quantum information, atomic clocks and tests of fundamental physics. However, this technique has not yet been applied to antimatter. Here we …


Sensing Optical Cavity Mismatch With A Mode-Converter And Quadrant Photodiode, Fabian Magana-Sandoval, Thomas Vo, Daniel Vander-Hyde, Jaclyn (Jax) Sanders, Stefan W. Ballmer Nov 2019

Sensing Optical Cavity Mismatch With A Mode-Converter And Quadrant Photodiode, Fabian Magana-Sandoval, Thomas Vo, Daniel Vander-Hyde, Jaclyn (Jax) Sanders, Stefan W. Ballmer

Physics Faculty Research and Publications

We present a new technique for sensing optical cavity mode mismatch and alignment by using a cylindrical lens mode converting telescope, radio-frequency quadrant photodiodes, and a heterodyne detection scheme. The telescope allows the conversion of the Laguerre-Gauss bullseye mode (LG01) into the 45° rotated Hermite-Gauss (“pringle”) mode (HG11), which can be easily measured with quadrant photodiodes. We show that we can convert to the HG basis optically, measure mode mismatched and alignment signals using widely produced radio-frequency quadrant photodiodes, and obtain a feedback error signal with heterodyne detection.


Observation Of The 1s–2p Lyman-Α Transition In Antihydrogen, M. Ahmadi, B. X.R. Alves, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, J. S. Hangst, W. N. Hardy, M. E. Hayden, E. D. Hunter, C. A. Isaac, M. A. Johnson, J. M. Jones, S. A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J. T. K. Mckenna, S. Menary, J. M. Michan, T. Momose, J. J. Munich, K. Olchanski, A. Olin, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, D, M. Starko, G. Stutter, C. So, Timothy Tharp, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele Sep 2018

Observation Of The 1s–2p Lyman-Α Transition In Antihydrogen, M. Ahmadi, B. X.R. Alves, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, J. S. Hangst, W. N. Hardy, M. E. Hayden, E. D. Hunter, C. A. Isaac, M. A. Johnson, J. M. Jones, S. A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J. T. K. Mckenna, S. Menary, J. M. Michan, T. Momose, J. J. Munich, K. Olchanski, A. Olin, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, D, M. Starko, G. Stutter, C. So, Timothy Tharp, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele

Physics Faculty Research and Publications

In 1906, Theodore Lyman discovered his eponymous series of transitions in the extreme-ultraviolet region of the atomic hydrogen spectrum. The patterns in the hydrogen spectrum helped to establish the emerging theory of quantum mechanics, which we now know governs the world at the atomic scale. Since then, studies involving the Lyman-α line—the 1S–2P transition at a wavelength of 121.6 nanometres—have played an important part in physics and astronomy, as one of the most fundamental atomic transitions in the Universe. For example, this transition has long been used by astronomers studying the intergalactic medium and testing cosmological models via the so-called …


Neutrino Interferometry For High-Precision Tests Of Lorentz Symmetry With Icecube, Karen Andeen, Icecube Collaboration Jul 2018

Neutrino Interferometry For High-Precision Tests Of Lorentz Symmetry With Icecube, Karen Andeen, Icecube Collaboration

Physics Faculty Research and Publications

Lorentz symmetry is a fundamental spacetime symmetry underlying both the standard model of particle physics and general relativity. This symmetry guarantees that physical phenomena are observed to be the same by all inertial observers. However, unified theories, such as string theory, allow for violation of this symmetry by inducing new spacetime structure at the quantum gravity scale. Thus, the discovery of Lorentz symmetry violation could be the first hint of these theories in nature. Here we report the results of the most precise test of spacetime symmetry in the neutrino sector to date. We use high-energy atmospheric neutrinos observed at …


Neutrino Emission From The Direction Of The Blazar Txs 0506+056 Prior To The Icecube-170922a Alert, Icecube Collaboration, Karen Andeen Jul 2018

Neutrino Emission From The Direction Of The Blazar Txs 0506+056 Prior To The Icecube-170922a Alert, Icecube Collaboration, Karen Andeen

Physics Faculty Research and Publications

A high-energy neutrino event detected by IceCube on 22 September 2017 was coincident in direction and time with a gamma-ray flare from the blazar TXS 0506+056. Prompted by this association, we investigated 9.5 years of IceCube neutrino observations to search for excess emission at the position of the blazar. We found an excess of high-energy neutrino events, with respect to atmospheric backgrounds, at that position between September 2014 and March 2015. Allowing for time-variable flux, this constitutes 3.5σ evidence for neutrino emission from the direction of TXS 0506+056, independent of and prior to the 2017 flaring episode. This suggests that …


Multimessenger Observations Of A Flaring Blazar Coincident With High-Energy Neutrino Icecube-170922a, Karen Andeen, Icecube Collaboration, Fermi-Lat, Agile, Asas-Sn, Hawc, H.E.S.S., Integral, Kanata, Kiso, Kapteyn, Liverpool Telescope, Subaru, Swift/Nustar, Veritas, Vla/17b-403 Jul 2018

Multimessenger Observations Of A Flaring Blazar Coincident With High-Energy Neutrino Icecube-170922a, Karen Andeen, Icecube Collaboration, Fermi-Lat, Agile, Asas-Sn, Hawc, H.E.S.S., Integral, Kanata, Kiso, Kapteyn, Liverpool Telescope, Subaru, Swift/Nustar, Veritas, Vla/17b-403

Physics Faculty Research and Publications

No abstract provided.


Creating A Ductus From Period Exemplars, Melissa Vigil May 2018

Creating A Ductus From Period Exemplars, Melissa Vigil

Physics Faculty Research and Publications

No abstract provided.


A Search For Neutrino Emission From Fast Radio Bursts With Six Years Of Icecube Data, Karen Andeen Apr 2018

A Search For Neutrino Emission From Fast Radio Bursts With Six Years Of Icecube Data, Karen Andeen

Physics Faculty Research and Publications

We present a search for coincidence between IceCube TeV neutrinos and fast radio bursts (FRBs). During the search period from 2010 May 31 to 2016 May 12, a total of 29 FRBs with 13 unique locations have been detected in the whole sky. An unbinned maximum likelihood method was used to search for spatial and temporal coincidence between neutrinos and FRBs in expanding time windows, in both the northern and southern hemispheres. No significant correlation was found in six years of IceCube data. Therefore, we set upper limits on neutrino fluence emitted by FRBs as a function of time window …


Search For Nonstandard Neutrino Interactions With Icecube Deepcore, Karen Andeen, Icecube Collaboration Apr 2018

Search For Nonstandard Neutrino Interactions With Icecube Deepcore, Karen Andeen, Icecube Collaboration

Physics Faculty Research and Publications

As atmospheric neutrinos propagate through the Earth, vacuumlike oscillations are modified by Standard Model neutral- and charged-current interactions with electrons. Theories beyond the Standard Model introduce heavy, TeV-scale bosons that can produce nonstandard neutrino interactions. These additional interactions may modify the Standard Model matter effect producing a measurable deviation from the prediction for atmospheric neutrino oscillations. The result described in this paper constrains nonstandard interaction parameters, building upon a previous analysis of atmospheric muon-neutrino disappearance with three years of IceCube DeepCore data. The best fit for the muon to tau flavor changing term is εμτ=−0.0005, with a 90% …


Characterization Of The 1s–2s Transition In Antihydrogen, M. Ahmadi, B. X.R. Alves, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, M. A. Johnson, J. M. Jones, S. A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J. T.K. Mckenna, S. Menary, T. Momose, J. J. Munich, K. Olchanski, A. Olin, P. Pusa, C. Ø. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, G. Stutter, C. So, Tim Tharp, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele Apr 2018

Characterization Of The 1s–2s Transition In Antihydrogen, M. Ahmadi, B. X.R. Alves, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, M. A. Johnson, J. M. Jones, S. A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J. T.K. Mckenna, S. Menary, T. Momose, J. J. Munich, K. Olchanski, A. Olin, P. Pusa, C. Ø. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, G. Stutter, C. So, Tim Tharp, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele

Physics Faculty Research and Publications

In 1928, Dirac published an equation1 that combined quantum mechanics and special relativity. Negative-energy solutions to this equation, rather than being unphysical as initially thought, represented a class of hitherto unobserved and unimagined particles—antimatter. The existence of particles of antimatter was confirmed with the discovery of the positron2 (or anti-electron) by Anderson in 1932, but it is still unknown why matter, rather than antimatter, survived after the Big Bang. As a result, experimental studies of antimatter3,4,5,6,7, including tests of fundamental symmetries such as charge–parity and charge–parity–time, and searches …


Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh Apr 2018

Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh

Master's Theses (2009 -)

NADPH-cytochrome p450 oxidoreductase (CYPOR) is a membrane-bound protein in living cells. CYPOR delivers electrons to cytochrome p450 proteins (CYPs) to catalyze metabolism of drugs and synthesis of steroids. Extraction and solubilization of CYPOR from the membrane is typically done with the TritonX-100 detergent. The amount of the solubilized protein by this detergent, however, remains relatively low to structurally analyze CYPOR with NMR spectroscopy. The goal of the first project in this thesis was to optimize the amount of the extracted CYPOR from the E. coli membrane using various detergents and additives. To this aim, non-ionic detergents with variable hydrophobicity (TritonX-100, …


How Do We Know What They Used?, Melissa Vigil Mar 2018

How Do We Know What They Used?, Melissa Vigil

Physics Faculty Research and Publications

No abstract provided.


Measurement Of Atmospheric Neutrino Oscillations At 6–56 Gev With Icecube Deepcore, Karen Andeen Feb 2018

Measurement Of Atmospheric Neutrino Oscillations At 6–56 Gev With Icecube Deepcore, Karen Andeen

Physics Faculty Research and Publications

We present a measurement of the atmospheric neutrino oscillation parameters using three years of data from the IceCube Neutrino Observatory. The DeepCore infill array in the center of IceCube enables the detection and reconstruction of neutrinos produced by the interaction of cosmic rays in Earth’s atmosphere at energies as low as ∼5  GeV. That energy threshold permits measurements of muon neutrino disappearance, over a range of baselines up to the diameter of the Earth, probing the same range of L/Eν as long-baseline experiments but with substantially higher-energy neutrinos. This analysis uses neutrinos from the full sky with reconstructed energies …


Disordered Kagomé Spin Ice, Noah Greenberg, Andrew Kunz Jan 2018

Disordered Kagomé Spin Ice, Noah Greenberg, Andrew Kunz

Physics Faculty Research and Publications

Artificial spin ice is made from a large array of patterned magnetic nanoislands designed to mimic naturally occurring spin ice materials. The geometrical arrangement of the kagomé lattice guarantees a frustrated arrangement of the islands’ magnetic moments at each vertex where the three magnetic nanoislands meet. This frustration leads to a highly degenerate ground state which gives rise to a finite (residual) entropy at zero temperature. In this work we use the Monte Carlo simulation to explore the effects of disorder in kagomé spin ice. Disorder is introduced to the system by randomly removing a known percentage of magnetic islands …


Enhanced Control And Reproducibility Of Non-Neutral Plasmas, Timothy Tharp, M. Ahmadi, B. X. R. Alves, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, M. A. Johnson, S. A. Jones, S. Jonsell, L. Kurchaninov, N. Madsen, M. Mathers, D. Maxwell, J. T. K. Mckenna, S. Menary, T. Momose, J. J. Munich, K. Olchanski, A. Olin, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, C. So, G. Stutter, J. E. Thompson, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele Jan 2018

Enhanced Control And Reproducibility Of Non-Neutral Plasmas, Timothy Tharp, M. Ahmadi, B. X. R. Alves, C. J. Baker, W. Bertsche, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, M. A. Johnson, S. A. Jones, S. Jonsell, L. Kurchaninov, N. Madsen, M. Mathers, D. Maxwell, J. T. K. Mckenna, S. Menary, T. Momose, J. J. Munich, K. Olchanski, A. Olin, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, C. So, G. Stutter, J. E. Thompson, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele

Physics Faculty Research and Publications

The simultaneous control of the density and particle number of non-neutral plasmas confined in Penning-Malmberg traps is demonstrated. Control is achieved by setting the plasma’s density by applying a rotating electric field while simultaneously fixing its axial potential via evaporative cooling. This novel method is particularly useful for stabilizing positron plasmas, as the procedures used to collect positrons from radioactive sources typically yield plasmas with variable densities and particle numbers; it also simplifies optimization studies that require plasma parameter scans. The reproducibility achieved by applying this technique to the positron and electron plasmas used by the ALPHA antihydrogen experiment at …


Search For High-Energy Neutrinos From Binary Neutron Star Merger Gw170817 With Antares, Icecube, And The Pierre Auger Observatory, Antares Collaboration, The Icecube Collaboration, The Pierre Auger Collaboration, Ligo Scientific Collaboration, Virgo Collaboration, Karen Andeen Nov 2017

Search For High-Energy Neutrinos From Binary Neutron Star Merger Gw170817 With Antares, Icecube, And The Pierre Auger Observatory, Antares Collaboration, The Icecube Collaboration, The Pierre Auger Collaboration, Ligo Scientific Collaboration, Virgo Collaboration, Karen Andeen

Physics Faculty Research and Publications

The Advanced LIGO and Advanced Virgo observatories recently discovered gravitational waves from a binary neutron star inspiral. A short gamma-ray burst (GRB) that followed the merger of this binary was also recorded by the FermiGamma-ray Burst Monitor (Fermi-GBM), and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory(INTEGRAL), indicating particle acceleration by the source. The precise location of the event was determined by optical detections of emission following the merger. We searched for high-energy neutrinos from the merger in the GeV–EeV energy range using the Antares, IceCube, and Pierre Auger Observatories. …


Measurement Of The Multi-Tev Neutrino Interaction Cross-Section With Icecube Using Earth Absorption, Karen Andeen, The Icecube Collaboration Nov 2017

Measurement Of The Multi-Tev Neutrino Interaction Cross-Section With Icecube Using Earth Absorption, Karen Andeen, The Icecube Collaboration

Physics Faculty Research and Publications

Neutrinos interact only very weakly, so they are extremely penetrating. The theoretical neutrino–nucleon interaction cross-section, however, increases with increasing neutrino energy, and neutrinos with energies above 40 teraelectronvolts (TeV) are expected to be absorbed as they pass through the Earth. Experimentally, the cross-section has been determined only at the relatively low energies (below 0.4 TeV) that are available at neutrino beams from accelerators1,2. Here we report a measurement of neutrino absorption by the Earth using a sample of 10,784 energetic upward-going neutrino-induced muons. The flux of high-energy neutrinos transiting long paths through the Earth is attenuated compared to …


Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, And Progressive Neurodegeneration In Mitopark Transgenic Mice, Monica Langley, Anamitra Ghosh, Adhithiya Charli, Souvarish Sarkar, Muhammet Ay, Jie Luo, Jacek Zielonka, Timothy Brenza, Brian Bennett, Huajun Jin, Shivani Ghaisas, Benjamin Schlichtmann, Dongsuk Kim, Vellareddy Anantharam, Arthi Kanthasamy, Balaji Narasimhan, Balaraman Kalyanaraman, Anumantha G. Kanthasamy Nov 2017

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, And Progressive Neurodegeneration In Mitopark Transgenic Mice, Monica Langley, Anamitra Ghosh, Adhithiya Charli, Souvarish Sarkar, Muhammet Ay, Jie Luo, Jacek Zielonka, Timothy Brenza, Brian Bennett, Huajun Jin, Shivani Ghaisas, Benjamin Schlichtmann, Dongsuk Kim, Vellareddy Anantharam, Arthi Kanthasamy, Balaji Narasimhan, Balaraman Kalyanaraman, Anumantha G. Kanthasamy

Physics Faculty Research and Publications

Aims: Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive motor deficits and degeneration of dopaminergic neurons. Caused by a number of genetic and environmental factors, mitochondrial dysfunction and oxidative stress play a role in neurodegeneration in PD. By selectively knocking out mitochondrial transcription factor A (TFAM) in dopaminergic neurons, the transgenic MitoPark mice recapitulate many signature features of the disease, including progressive motor deficits, neuronal loss, and protein inclusions. In the present study, we evaluated the neuroprotective efficacy of a novel mitochondrially targeted antioxidant, Mito-apocynin, in MitoPark mice and cell culture models of neuroinflammation and mitochondrial dysfunction.

Results: …


Multiwavelength Follow-Up Of A Rare Icecube Neutrino Multiplet, Karen Andeen Nov 2017

Multiwavelength Follow-Up Of A Rare Icecube Neutrino Multiplet, Karen Andeen

Physics Faculty Research and Publications

On February 17, 2016, the IceCube real-time neutrino search identified, for the first time, three muon neutrino candidates arriving within 100 s of one another, consistent with coming from the same point in the sky. Such a triplet is expected once every 13.7 years as a random coincidence of background events. However, considering the lifetime of the follow-up program the probability of detecting at least one triplet from atmospheric background is 32%. Follow-up observatories were notified in order to search for an electromagnetic counterpart. Observations were obtained by Swift’s X-ray telescope, by ASAS-SN, LCO and MASTER at optical wavelengths, …


Constraints On Galactic Neutrino Emission With Seven Years Of Icecube Data, Karen Andeen Nov 2017

Constraints On Galactic Neutrino Emission With Seven Years Of Icecube Data, Karen Andeen

Physics Faculty Research and Publications

The origins of high-energy astrophysical neutrinos remain a mystery despite extensive searches for their sources. We present constraints from seven years of IceCube Neutrino Observatory muon data on the neutrino flux coming from the Galactic plane. This flux is expected from cosmic-ray interactions with the interstellar medium or near localized sources. Two methods were developed to test for a spatially extended flux from the entire plane, both of which are maximum likelihood fits but with different signal and background modeling techniques. We consider three templates for Galactic neutrino emission based primarily on gamma-ray observations and models that cover a wide …


Multi-Messenger Observations Of A Binary Neutron Star Merger, Karen Andeen Oct 2017

Multi-Messenger Observations Of A Binary Neutron Star Merger, Karen Andeen

Physics Faculty Research and Publications

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to …


Measurement Of The Νμ Energy Spectrum With Icecube-79, Karen Andeen Oct 2017

Measurement Of The Νμ Energy Spectrum With Icecube-79, Karen Andeen

Physics Faculty Research and Publications

IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The νμ energy unfolding described in this paper is based on data taken with IceCube in its 79-string configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of amultivariate classification process based on machine learning. The subsequent unfolding was performed using the software TRUEE. The resulting spectrum covers an Eν-range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows …


Antihydrogen Accumulation For Fundamental Symmetry Tests, Timothy Tharp, M. Ahmadi, P. Nolan, P. Pusa, B. X. R. Alves, T. Friesen, C. O. Rasmussen, G. Stutter, C. J. Baker, M. Charlton, S. Eriksson, C. A. Isaac, S. A. Jones, N. Madsen, D. Maxwell, M. Sameed, D. P. Van Der Werf, W. Bertsche, M. A. Johnson, E. Butler, A. Capra, R. Collister, M. C. Fujiwara, L. Kurchaninov, J. T. K. Mckenna, J. M. Michan, K. Olchanski, A. Olin, C. Carruth, J. Fajans, J. S. Wurtele, C. L. Cesar, R. L. Sacramento, D. M. Silveira, S. Cohen, A. Evans, C. So, R. I. Thompson, N. Evetts, W. N. Hardy, T. Momose, A. Gutierrez, M. E. Hayden, J. J. Munich, A. Ishida, S. Jonsell, M. Mathers, S. Menary, J. E. Thompson, J.M. Michan, F. Robicheaux, E. Sarid, S. Stracha Sep 2017

Antihydrogen Accumulation For Fundamental Symmetry Tests, Timothy Tharp, M. Ahmadi, P. Nolan, P. Pusa, B. X. R. Alves, T. Friesen, C. O. Rasmussen, G. Stutter, C. J. Baker, M. Charlton, S. Eriksson, C. A. Isaac, S. A. Jones, N. Madsen, D. Maxwell, M. Sameed, D. P. Van Der Werf, W. Bertsche, M. A. Johnson, E. Butler, A. Capra, R. Collister, M. C. Fujiwara, L. Kurchaninov, J. T. K. Mckenna, J. M. Michan, K. Olchanski, A. Olin, C. Carruth, J. Fajans, J. S. Wurtele, C. L. Cesar, R. L. Sacramento, D. M. Silveira, S. Cohen, A. Evans, C. So, R. I. Thompson, N. Evetts, W. N. Hardy, T. Momose, A. Gutierrez, M. E. Hayden, J. J. Munich, A. Ishida, S. Jonsell, M. Mathers, S. Menary, J. E. Thompson, J.M. Michan, F. Robicheaux, E. Sarid, S. Stracha

Physics Faculty Research and Publications

Antihydrogen, a positron bound to an antiproton, is the simplest anti-atom. Its structure and properties are expected to mirror those of the hydrogen atom. Prospects for precision comparisons of the two, as tests of fundamental symmetries, are driving a vibrant programme of research. In this regard, a limiting factor in most experiments is the availability of large numbers of cold ground state antihydrogen atoms. Here, we describe how an improved synthesis process results in a maximum rate of 10.5 ± 0.6 atoms trapped and detected per cycle, corresponding to more than an order of magnitude improvement over previous work. Additionally, …


Search For Astrophysical Sources Of Neutrinos Using Cascade Events In Icecube, Karen Andeen Sep 2017

Search For Astrophysical Sources Of Neutrinos Using Cascade Events In Icecube, Karen Andeen

Physics Faculty Research and Publications

The IceCube neutrino observatory has established the existence of a flux of high-energy astrophysical neutrinos, which is inconsistent with the expectation from atmospheric backgrounds at a significance greater than 5σ. This flux has been observed in analyses of both track events from muon neutrino interactions and cascade events from interactions of all neutrino flavors. Searches for astrophysical neutrino sources have focused on track events due to the significantly better angular resolution of track reconstructions. To date, no such sources have been confirmed. Here we present the first search for astrophysical neutrino sources using cascades interacting in IceCube with …


Search For Neutrinos From Dark Matter Self-Annihilations In The Center Of The Milky Way With 3 Years Of Icecube/Deepcore, Karen Andeen, Icecube Collaboration Sep 2017

Search For Neutrinos From Dark Matter Self-Annihilations In The Center Of The Milky Way With 3 Years Of Icecube/Deepcore, Karen Andeen, Icecube Collaboration

Physics Faculty Research and Publications

We present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days of data we found no significant excess of neutrinos over the background of neutrinos produced in atmospheric air showers from cosmic ray interactions. We derive upper limits on the velocity averaged product of the dark matter self-annihilation cross section and the relative velocity of the dark matter particles ⟨ σ A v ⟩

. Upper limits are set for dark matter particle candidate masses ranging from 10 GeV up to 1 TeV while considering annihilation …


Observation Of The Hyperfine Spectrum Of Antihydrogen, M. Ahmadi, B. X. R. Alves, C. J. Baker, W. Bertsche, E. Butler, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, A. Gutierrez, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, A. Ishida, M. A. Johnson, S. A. Jones, S. Jonsell, L. Kurchaninov, N. Madsen, M. Mathers, D. Maxwell, J. T. K. Mckenna, S. Menary, J. M. Michan, T. Momose, J. J. Munich, P. Nolan, K. Olchanski, A. Olin, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, S. Stracka, G. Stutter, C. So, Timothy Tharp, J. E. Thompson, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele Aug 2017

Observation Of The Hyperfine Spectrum Of Antihydrogen, M. Ahmadi, B. X. R. Alves, C. J. Baker, W. Bertsche, E. Butler, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, A. Gutierrez, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, A. Ishida, M. A. Johnson, S. A. Jones, S. Jonsell, L. Kurchaninov, N. Madsen, M. Mathers, D. Maxwell, J. T. K. Mckenna, S. Menary, J. M. Michan, T. Momose, J. J. Munich, P. Nolan, K. Olchanski, A. Olin, P. Pusa, C. O. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, S. Stracka, G. Stutter, C. So, Timothy Tharp, J. E. Thompson, R. I. Thompson, D. P. Van Der Werf, J. S. Wurtele

Physics Faculty Research and Publications

The observation of hyperfine structure in atomic hydrogen by Rabi and co-workers1,2,3 and the measurement4 of the zero-field ground-state splitting at the level of seven parts in 1013 are important achievements of mid-twentieth-century physics. The work that led to these achievements also provided the first evidence for the anomalous magnetic moment of the electron5,6,7,8, inspired Schwinger’s relativistic theory of quantum electrodynamics9,10 and gave rise to the hydrogen maser11, which is a critical component of modern navigation, geo-positioning and very-long-baseline interferometry …


Search For High-Energy Neutrinos From Gravitational Wave Event Gw151226 And Candidate Lvt151012 With Antares And Icecube, Karen Andeen, Antares Collaboration, Icecube Collaboration, Ligo Scientific Collaboration, Virgo Collaboration Jul 2017

Search For High-Energy Neutrinos From Gravitational Wave Event Gw151226 And Candidate Lvt151012 With Antares And Icecube, Karen Andeen, Antares Collaboration, Icecube Collaboration, Ligo Scientific Collaboration, Virgo Collaboration

Physics Faculty Research and Publications

The Advanced LIGO observatories detected gravitational waves from two binary black hole mergers during their first observation run (O1). We present a high-energy neutrino follow-up search for the second gravitational wave event, GW151226, as well as for gravitational wave candidate LVT151012. We find two and four neutrino candidates detected by IceCube, and one and zero detected by Antares, within ±500  s around the respective gravitational wave signals, consistent with the expected background rate. None of these neutrino candidates are found to be directionally coincident with GW151226 or LVT151012. We use nondetection to constrain isotropic-equivalent high-energy neutrino emission from GW151226, adopting …


Extending The Search For Muon Neutrinos Coincident With Gamma-Ray Bursts In Icecube Data, Karen Andeen Jul 2017

Extending The Search For Muon Neutrinos Coincident With Gamma-Ray Bursts In Icecube Data, Karen Andeen

Physics Faculty Research and Publications

We present an all-sky search for muon neutrinos produced during the prompt γ-ray emission of 1172 gamma-ray bursts (GRBs) with the IceCube Neutrino Observatory. The detection of these neutrinos would constitute evidence for ultra-high-energy cosmic-ray (UHECR) production in GRBs, as interactions between accelerated protons and the prompt γ-ray field would yield charged pions, which decay to neutrinos. A previously reported search for muon neutrino tracks from northern hemisphere GRBs has been extended to include three additional years of IceCube data. A search for such tracks from southern hemisphere GRBs in five years of IceCube data has been introduced …