Physics Commons^™

Numerical Simulation Of Adaptive Metabolic Response To Anti-Angiogenic Treatment In Renal Cell Carcinoma, Saranya Varakunan

Undergraduate Student Research Internships Conference

Renal cell carcinoma, a malignant kidney cancer, is often treated using anti-angiogenic drugs to prevent the growth of blood vessels within the tumour. Although tumours initially respond to this treatment, they eventually develop resistance. This resistance is hypothesized to be caused by a switch to a symbiotic metabolism that allows cells to survive even with a low blood supply.

This project seeks to computationally model the transport of oxygen, lactate, and glucose within a tumour in order to examine how cancer metabolism adapts to changes in blood vessels.

Topographic Signatures Of Geodynamics, Samuel G. Roy

Electronic Theses and Dissertations

The surface of the Earth retains an imperfect memory of the diverse geodynamic, climatic, and surface transport processes that cooperatively drive the evolution of Earth. In this thesis I explore the potential of using topographic analysis and landscape evolution models to unlock past and/or present evidence for geodynamic activity. I explore the potential isolated effects of geodynamics on landscape evolution, particularly focusing on two byproducts of tectonic strain: rock displacement and damage. Field evidence supports a strong correlation between rock damage and erodibility, and a numerical sensitivity analysis supports the hypothesis that an order of magnitude weakening in rock, well …