Mathematics Commons^™

A Study Of Poisson And Related Processes With Applications, Phillip Mingola

Chancellor’s Honors Program Projects

No abstract provided.

The Torsion Angle Of Random Walks, Mu He

Masters Theses & Specialist Projects

In this thesis, we study the expected mean of the torsion angle of an n-step
equilateral random walk in 3D. We consider the random walk is generated within a confining sphere or without a confining sphere: given three consecutive vectors ^→e₁ , ^→e₂ , and ^→e₃ of the random walk then the vectors ^→e₁ and ^→e₂ define a plane and the vectors ^→e₂ and ^→e₃ define a second plane. The angle between the two planes is called the torsion angle of the three vectors. Algorithms are …

Analyzing And Solving Non-Linear Stochastic Dynamic Models On Non-Periodic Discrete Time Domains, Gang Cheng

Masters Theses & Specialist Projects

Stochastic dynamic programming is a recursive method for solving sequential or multistage decision problems. It helps economists and mathematicians construct and solve a huge variety of sequential decision making problems in stochastic cases. Research on stochastic dynamic programming is important and meaningful because stochastic dynamic programming reflects the behavior of the decision maker without risk aversion; i.e., decision making under uncertainty. In the solution process, it is extremely difficult to represent the existing or future state precisely since uncertainty is a state of having limited knowledge. Indeed, compared to the deterministic case, which is decision making under certainty, the stochastic …

Quantitative Interpretation Of A Genetic Model Of Carcinogenesis Using Computer Simulations, Donghai Dai, Brandon Beck, Xiaofang Wang, Cory Howk, Yi Li

Donghai Dai

The genetic model of tumorigenesis by Vogelstein et al. (V theory) and the molecular definition of cancer hallmarks by Hanahan and Weinberg (W theory) represent two of the most comprehensive and systemic understandings of cancer. Here, we develop a mathematical model that quantitatively interprets these seminal cancer theories, starting from a set of equations describing the short life cycle of an individual cell in uterine epithelium during tissue regeneration. The process of malignant transformation of an individual cell is followed and the tissue (or tumor) is described as a composite of individual cells in order to quantitatively account for intra-tumor …

Age-Specific Signatures Of Glioblastoma At The Genomic, Genetic, And Epigenetic Levels, Serdar Bozdag, Aiguo Li, Gregory Riddick, Yuri Kotliarov, Mehmet Baysan, Fabio M. Iwamoto, Margaret C. Cam, Svetlana Kotliarova, Howard A. Fine

Mathematics, Statistics and Computer Science Faculty Research and Publications

Age is a powerful predictor of survival in glioblastoma multiforme (GBM) yet the biological basis for the difference in clinical outcome is mostly unknown. Discovering genes and pathways that would explain age-specific survival difference could generate opportunities for novel therapeutics for GBM. Here we have integrated gene expression, exon expression, microRNA expression, copy number alteration, SNP, whole exome sequence, and DNA methylation data sets of a cohort of GBM patients in The Cancer Genome Atlas (TCGA) project to discover age-specific signatures at the transcriptional, genetic, and epigenetic levels and validated our findings on the REMBRANDT data set. We found major …

Combinatorial Pooling Enables Selective Sequencing Of The Barley Gene Space, Stefano Lonardi, Denisa Duma, Matthew Alpert, Francesca Cordero, Marco Beccuti, Prasanna R. Bhat, Yonghui Wu, Gianfranco Ciardo, Burair Alsaihati, Steve Wanamaker, Josh Resnik, Serdar Bozdag, Ming-Cheng Luo, Timothy J. Close

Mathematics, Statistics and Computer Science Faculty Research and Publications

For the vast majority of species – including many economically or ecologically important organisms, progress in biological research is hampered due to the lack of a reference genome sequence. Despite recent advances in sequencing technologies, several factors still limit the availability of such a critical resource. At the same time, many research groups and international consortia have already produced BAC libraries and physical maps and now are in a position to proceed with the development of whole-genome sequences organized around a physical map anchored to a genetic map. We propose a BAC-by-BAC sequencing protocol that combines combinatorial pooling design and …

Direct Eit Reconstructions Of Complex Admittivities On A Chest-Shaped Domain In 2-D, Sarah J. Hamilton, Jennifer L. Mueller

Mathematics, Statistics and Computer Science Faculty Research and Publications

Electrical impedance tomography (EIT) is a medical imaging technique in which current is applied on electrodes on the surface of the body, the resulting voltage is measured, and an inverse problem is solved to recover the conductivity and/or permittivity in the interior. Images are then formed from the reconstructed conductivity and permittivity distributions. In the 2-D geometry, EIT is clinically useful for chest imaging. In this work, an implementation of a D-bar method for complex admittivities on a general 2-D domain is presented. In particular, reconstructions are computed on a chest-shaped domain for several realistic phantoms including a simulated pneumothorax, …

A Data Generating Review That Bops, Twists And Pulls At Misconceptions, Kimberly Gardner

Faculty and Research Publications

Statistics is an integral part of the K-12 mathematics curriculum (age 5-18). Naturally, students construct misconceptions of what they learn. This article discusses The Bop It^© Challenge, a review activity assesses student understanding and reveals their misundertandings of statistical concepts.

Repeated Changes In Reported Sexual Orientation Identity Linked To Substance Use Behaviors In Youth, Miles Q. Ott, David Wypij, Heather L. Corliss, Margaret Rosario, Sari L. Reisner, Allegra R. Gordon, S. Bryn Austin

Statistical and Data Sciences: Faculty Publications

Purpose—Previous studies have found that sexual minority (e.g., lesbian, gay, bisexual) adolescents are at higher risk of substance use than heterosexuals, but few have examined how changes in sexual orientation over time may relate to substance use. We examined the associations between change in sexual orientation identity and marijuana use, tobacco use, and binge drinking in U.S. youth.

Methods—Prospective data from 10,515 U.S. youth ages 12-27 years in a longitudinal cohort study were analyzed using sexual orientation identity mobility measure M (frequency of change from 0 [no change] to 1 [change at every wave]) in up to five waves of …

Some New Applications Of P-P Plots, Isha Dewan, Subhash C. Kochar

Mathematics and Statistics Faculty Publications and Presentations

The P-P plot is a powerful graphical tool to compare stochastically the magnitudes of two random variables. In this note, we introduce a new partial order, called P?P order based on P-P plots. For a pair of random variables (X ₁, Y₁) and (X ₂, Y ₂) one can see the relative precedence of Y ₂ over X ₂ versus that of Y ₁ over X ₁ using P-P order. We show that several seemingly very technical and difficult concepts like convex transform order and super-additive ordering can be easily explained with the …

Temporal Dynamics Of Neural Activity In The Olfactory Receptor Neurons During Odor Exposure, Danni Liu, Jun Xia

Georgia State Undergraduate Research Conference

No abstract provided.

A Graph-Theoretical Approach To The Selection Of The Minimum Tiling Path From A Physical Map, Serdar Bozdag

Mathematics, Statistics and Computer Science Faculty Research and Publications

The problem of computing the minimum tiling path (MTP) from a set of clones arranged in a physical map is a cornerstone of hierarchical (clone-by-clone) genome sequencing projects. We formulate this problem in a graph theoretical framework, and then solve by a combination of minimum hitting set and minimum spanning tree algorithms. The tool implementing this strategy, called FMTP, shows improved performance compared to the widely used software FPC. When we execute FMTP and FPC on the same physical map, the MTP produced by FMTP covers a higher portion of the genome, and uses a smaller number of clones. For …

Mind The Gaps, Paul Bankston

Mathematics, Statistics and Computer Science Faculty Research and Publications

No abstract provided.

Rattus Model Utilizing Selective Pulmonary Ischemia Induces Bronchiolitis Obliterans Organizing Pneumonia, John C. Densmore, Paul M. Jeziorczak, Anne V. Clough, Kirkwood A. Pritchard Jr, Breana Cummens, Meetha Medhora, Arjun Rao, Elizabeth R. Jacobs

Mathematics, Statistics and Computer Science Faculty Research and Publications

Bronchiolitis obliterans organizing pneumonia (BOOP), a morbid condition when associated with lung transplant and chronic lung disease, is believed to be a complication of ischemia. Our goal was to develop a simple and reliable model of lung ischemia in the Sprague-Dawley rat that would produce BOOP. Unilateral ischemia without airway occlusion was produced by an occlusive slipknot placed around the left main pulmonary artery. Studies were performed 7 days later. Relative pulmonary and systemic flow to each lung was measured by injection of technetium Tc 99m macroaggregated albumin. Histological sections were examined for structure and necrosis and scored for BOOP. …

Data Combination From Multiple Sources Under Measurement Error, Hugo Gasca-Aragon

Open Access Dissertations

Regulatory Agencies are responsible for monitoring the performance of particular measurement communities. In order to achieve their objectives, they sponsor Intercomparison exercises between the members of these communities. The Intercomparison Exercise Program for Organic Contaminants in the Marine Environment is an ongoing NIST/NOAA program. It was started in 1986 and there have been 19 studies to date. Using this data as a motivation we review the theory and practices applied to its analysis.

It is a common practice to apply some kind of filter to the comparison study data. These filters go from outliers detection and exclusion to exclusion of …

A Spectral Order For Infinite Dimensional Quantum Spaces, Joe Mashburn

Mathematics Faculty Publications

In this paper we extend the spectral order of Coecke and Martin to infinite-dimensional quantum states. Many properties present in the finite-dimensional case are preserved, but some of the most important are lost. The order is constructed and its properties analysed. Most of the useful measurements of information content are lost. Shannon entropy is defined on only a part of the model, and that part is not a closed subset of the model. The finite parts of the lattices used by Birkhoff and von Neumann as models for classical and quantum logic appear as subsets of the models for infinite …

Some Minor-Closed Classes Of Signed Graphs, Dan Slilaty, Xiangqian Zhou

Mathematics and Statistics Faculty Publications

We define four minor-closed classes of signed graphs in terms of embeddability in the annulus, projective plane, torus, and Klein bottle. We give the full list of 20 excluded minors for the smallest class and make a conjecture about the largest class.

3e: Energy-Efficient Elastic Scheduling For Independent Tasks In Heterogeneous Computing Systems, Xiaomin Zhu, Rong Ge, Jinguang Sun, Chuan He

Mathematics, Statistics and Computer Science Faculty Research and Publications

Reducing energy consumption is a major design constraint for modern heterogeneous computing systems to minimize electricity cost, improve system reliability and protect environment. Conventional energy-efficient scheduling strategies developed on these systems do not sufficiently exploit the system elasticity and adaptability for maximum energy savings, and do not simultaneously take account of user expected finish time. In this paper, we develop a novel scheduling strategy named energy-efficient elastic (3E) scheduling for aperiodic, independent and non-real-time tasks with user expected finish times on DVFS-enabled heterogeneous computing systems. The 3E strategy adjusts processors’ supply voltages and frequencies according to the system workload, and …

The Performance Of Mlem For Dynamic Imaging From Simulated Few-View, Multi-Pinhole Spect, Dan Ma, Paul Arthur Wolf, Anne V. Clough, Taly Gilat Schmidt

Mathematics, Statistics and Computer Science Faculty Research and Publications

Stationary small-animal SPECT systems are being developed for rapid dynamic imaging from limited angular views. This work quantified, through simulations, the performance of Maximum Likelihood Expectation Maximization (MLEM) for reconstructing a time-activity curve (TAC) with uptake duration of a few seconds from a stationary, three-camera multi-pinhole SPECT system. The study also quantified the benefits of a heuristic method of initializing the reconstruction with a prior image reconstructed from a conventional number of views, for example from data acquired during the late-study portion of the dynamic TAC. We refer to MLEM reconstruction initialized by a prior-image initial guess (IG) as MLEM …

From Solute Transport To Chemical Weathering, Allen Hunt, Thomas E. Skinner

Physics Seminars

A theory for conservative solute transport, based on concepts from percolation theory, is applied directly to reactive solute transport. Chemical reactions are assumed to have reached equilibrium at the scale of an individual pore, but at larger length scales, equilibration is limited by solute transport velocities, which are not the same as fluid velocities! The results of this theory already predicted observed dispersivity values for conservative solute transport over ten orders of magnitude of length scale as well as the variation of solute arrival time distributions with medium saturation. We now show that the solute velocity predicts the time-dependence of …

Characterizations Of Exponentiated Distributions, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

Various characterizations of the class of exponentiated distributions are presented. These characterizations are based on a simple relationship between two truncated moments and based on functions of the nth order statistic. The results are applied to certain well-known members of this class.

Rna Profiles Of Porcine Embryos During Genome Activation Reveal Complex Metabolic Switch Sensitive To In Vitro Conditions, Olga Østrup, Gayla R. Olbricht, Esben Østrup, Poul Hyttel, Philippe Collas, Ryan A. Cabot

Mathematics and Statistics Faculty Research & Creative Works

Fertilization is followed by complex changes in cytoplasmic composition and extensive chromatin reprogramming which results in the abundant activation of totipotent embryonic genome at embryonic genome activation (EGA). While chromatin reprogramming has been widely studied in several species, only a handful of reports characterize changing transcriptome profiles and resulting metabolic changes in cleavage stage embryos. The aims of the current study were to investigate RNA profiles of in vivo developed (ivv) and in vitro produced (ivt) porcine embryos before (2-cell stage) and after (late 4-cell stage) EGA and determine major metabolic changes that regulate totipotency. The period before EGA was …

Modeling, Analysis, And Applications Of Complex Systems, Chuandong Li, Xiaodi Li, Shukai Duan, Yanzhi Zhang

Mathematics and Statistics Faculty Research & Creative Works

Recent advances in theory and applications of complex dynamical systems have contributed much to the successful handling of certain problems in biology, physics, economics, engineering, and so forth that until recently were thought too difficult to be analyzed. These complex systems may be characterized by systems with uncertainty, impulse, time delay, stochastic perturbation, hybrid dynamics, distributed dynamics, and chaotic dynamics. The overall aim of this special issue is to bring together the latest or innovative knowledge and advances in mathematics for handling complex systems, which may depend largely on methods from mathematical analysis, artificial intelligence, statistics, and engineering, including nonlinear …

A Bound On The Vertical Transport Of Heat In The 'Ultimate' State Of Slippery Convection At Large Prandtl Numbers, Xiaoming Wang, Jared P. Whitehead

Mathematics and Statistics Faculty Research & Creative Works

An upper bound on the rate of vertical heat transport is established in three dimensions for stress-free velocity boundary conditions on horizontally periodic plates. a variation of the background method is implemented that allows negative values of the quadratic form to yield 'small' (O.1=Pr/) corrections to the subsequent bound. for large (but finite) Prandtl numbers this bound is an improvement over the 'ultimate' Ra1=2 scaling and, in the limit of infinite Pr, agrees with the bound of Ra5=12 recently derived in that limit for stress-free boundaries. © 2013 Cambridge University Press.

Well-Posedness Of The Hele-Shaw-Cahn-Hilliard System, Xiaoming Wang, Zhifei Zhang

Mathematics and Statistics Faculty Research & Creative Works

We study the well-posedness of the Hele-Shaw-Cahn-Hilliard system modeling binary fluid flow in porous media with arbitrary viscosity contrast but matched density between the components. for initial data in Hs, s>d2+1, the existence and uniqueness of solution in C([0,T];Hs) ∪L2(0,T;Hs+2) that is global in time in the two-dimensional case (d=2) and local in time in the three-dimensional case (d=3) are established. Several blow-up criterions in the three-dimensional case are provided as well. One of the tools that we utilized is the Littlewood-Paley theory in order to establish certain key commutator estimates. © 2012 Elsevier Masson SAS.

Complex Dynamics In Predator-Prey Models With Nonmonotonic Functional Response And Seasonal Harvesting, Jicai Huang, Jing Chen, Yijun Gong, Weipeng Zhang

Mathematics Faculty Articles

In this paper we study the complex dynamics of predator-prey systems with nonmonotonic functional response and harvesting. When the harvesting is constant-yield for prey, it is shown that various kinds of bifurcations, such as saddle-node bifurcation, degenerate Hopf bifurcation, and Bogdanov-Takens bifurcation, occur in the model as parameters vary. The existence of two limit cycles and a homoclinic loop is established by numerical simulations. When the harvesting is seasonal for both species, sufficient conditions for the existence of an asymptotically stable periodic solution and bifurcation of a stable periodic orbit into a stable invariant torus of the model are given. …

Torus Orbits On Homogeneous Varieties And Kac Polynomials Of Quivers, Paul Gunnells, Emmanuel Letellier, Fernando Rodriguez Villegas

Paul Gunnells

In this paper we prove that the counting polynomials of certain torus orbits in products of partial flag varieties coincides with the Kac polynomials of supernova quivers, which arise in the study of the moduli spaces of certain irregular meromorphic connections on trivial bundles over the projective line. We also prove that these polynomials can be expressed as a specialization of Tutte polynomials of certain graphs providing a combinatorial proof of the non-negativity of their coefficients.

On The Cohomology Of Linear Groups Over Imaginary Quadratic Fields, Herbert Gangl, Paul Gunnells, Jonathan Hanke, Achill Schurmann, Mathieu Dutour Sikiric, Dan Yasaki

Paul Gunnells

Let 􀀀 be the group GLN(OD), where OD is the ring of integers in the imaginary quadratic field with discriminant D < 0. In this paper we investigate the cohomology of 􀀀 for N = 3, 4 and for a selection of discriminants: D −24 when N = 3, and D = −3,−4 when N = 4. In particular we compute the integral cohomology of 􀀀 up to p-power torsion for small primes p. Our main tool is the polyhedral reduction theory for 􀀀 developed by Ash [4, Ch. II] and Koecher [18]. Our results extend work of Staffeldt [29], who treated the case n = 3, D = −4. In a sequel [11] to this paper, we will apply some of these results to the computations with the K-groups K4(OD), when D = −3,−4.

Genome-Wide Associations Of Signaling Pathways In Glioblastoma Multiforme, Serdar Bozdag, Stefan Wuchty, Alexei Vazquez, Peter O. Bauer

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background: eQTL analysis is a powerful method that allows the identification of causal genomic alterations, providing an explanation of expression changes of single genes. However, genes mediate their biological roles in groups rather than in isolation, prompting us to extend the concept of eQTLs to whole gene pathways. Methods: We combined matched genomic alteration and gene expression data of glioblastoma patients and determined associations between the expression of signaling pathways and genomic copy number alterations with a non-linear machine learning approach. Results: Expectedly, over-expressed pathways were largely associated to tag-loci on chromosomes with signature alterations. Surprisingly, tag-loci that were associated …

Generalized Least-Squares Regressions I: Efficient Derivations, Nataniel Greene

Publications and Research

Ordinary least-squares regression suffers from a fundamental lack of symmetry: the regression line of y given x and the regression line of x given y are not inverses of each other. Alternative symmetric regression methods have been developed to address this concern, notably: orthogonal regression and geometric mean regression. This paper presents in detail a variety of least squares regression methods which may not have been known or fully explicated. The derivation of each method is made efficient through the use of Ehrenberg's formula for the ordinary least-squares error and through the extraction of a weight function g(b) which characterizes …