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A Method For Finding Standard Error Estimates For Rma Expression Levels Using Bootstrap, Gabriel Nicholas
A Method For Finding Standard Error Estimates For Rma Expression Levels Using Bootstrap, Gabriel Nicholas
All Graduate Plan B and other Reports, Spring 1920 to Spring 2023
Oligonucleotide arrays are used in many applications. Affymetrix GeneChip arrays are widely used. Before researchers can use the information from these arrays, the raw data must be transformed and summarized into a more meaningful and usable form. One of the more popular methods for doing so is RMA (Robust Multi-array Analysis).
A problem with RMA is that the end result (estimated gene expression levels) is based on a fairly complicated process that is unusual. Specifically, there is no closed-form estimate of standard errors for the estimated gene expression levels. The current recommendation is to use a naive estimate for the …