Mathematics Commons^™

Transmission Dynamics Of Avian Influenza Among Poultry With And Without Vaccination, Qiao Liang

Mathematics & Statistics ETDs

The continuing avian influenza (AI) out break that began in late 2003 and early 2004 has been disastrous for the poultry industry worldwide. It has resulted in severe socio-economic damage, and it has raised serious concerns for general public health. In this research, we use mathematics to analyze transmission dynamics of AI among poultry. We use a status-based approach to construct systems of differential equations to describe virus transmission dynamics. We develop theoretical means to eradicate the spread of the disease, and we calculate the size of healthy and infected populations during an AI outbreak, and the final population size …

A Method For Finding Standard Error Estimates For Rma Expression Levels Using Bootstrap, Gabriel Nicholas

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Oligonucleotide arrays are used in many applications. Affymetrix GeneChip arrays are widely used. Before researchers can use the information from these arrays, the raw data must be transformed and summarized into a more meaningful and usable form. One of the more popular methods for doing so is RMA (Robust Multi-array Analysis).

A problem with RMA is that the end result (estimated gene expression levels) is based on a fairly complicated process that is unusual. Specifically, there is no closed-form estimate of standard errors for the estimated gene expression levels. The current recommendation is to use a naive estimate for the …