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Quantitative Structure-Activity Relationships And Ecological Risk Assessment: An Overview Of Predictive Aquatic Toxicology Research, Steven P. Bradbury
Quantitative Structure-Activity Relationships And Ecological Risk Assessment: An Overview Of Predictive Aquatic Toxicology Research, Steven P. Bradbury
Steven P. Bradbury
In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible tools for predicting the toxicity of chemicals when little or no empirical data are available. A fundamental understanding of toxicological principles has been considered an important component to the acceptance and application of QSAR approaches as biologically relevant in ecological risk assessments. As a consequence, there has been an evolution of QSAR development and application from that of a chemical-class perspective to one that is more consistent with assumptions regarding modes of toxic action. In this review, techniques to assess modes of toxic action from …