Natural Resources Management and Policy Commons^™

Fish Acute Toxicity Syndromes And Their Use In The Qsar Approach To Hazard Assessment, Steven P. Bradbury, James M. Mckim, Gerald J. Niemi

Steven P. Bradbury

Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited and the number of industrial chemicals requiring evaluation is overwhelming. The use of quantitative structure activity relationship (QSAR) models as rapid and predictive screening tools to select more potentially hazardous chemicals for in-depth laboratory evaluation has been proposed. Further implementation and refinement of quantitative structure-toxicity relationships in aquatic toxicology and hazard assessment requires the development of a "mode-of-action" database. With such a database, a qualitative structure-activity relationship can be formulated to assign the proper mode of action, and …