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Do Pharmaceuticals In The Environment Pose A Risk To Wildlife?, Thomas G. Bean, Elizabeth A. Chadwick, Marta Herrero‐Villar, Rafael Mateo, Vinny Naidoo, Barnett A. Rattner
Do Pharmaceuticals In The Environment Pose A Risk To Wildlife?, Thomas G. Bean, Elizabeth A. Chadwick, Marta Herrero‐Villar, Rafael Mateo, Vinny Naidoo, Barnett A. Rattner
United States Geological Survey: Staff Publications
The vast majority of knowledge related to the question “To what extent do pharmaceuticals in the environment pose a risk to wildlife?” stems from the Asian vulture crisis (>99% decline of some species of Old World vultures on the Indian subcontinent related to the veterinary use of the nonsteroidal anti‐inflammatory drug [NSAID] diclofenac). The hazard of diclofenac and other NSAIDs (carprofen, flunixin, ketoprofen, nimesulide, phenylbutazone) to vultures and other avian species has since been demonstrated; indeed, only meloxicam and tolfenamic acid have been found to be vulture‐safe. Since diclofenac was approved for veterinary use in Spain and Italy in …
Transcriptome Signatures Of Wastewater Effluent Exposure In Larval Zebrafish Vary With Seasonal Mixture Composition In An Effluent-Dominated Stream, Emma B. Meade, Luke R. Iwanowicz, Nicklaus Neureuther, Gregory H. Lefevre, Dana W. Kolpin, Hui Zhi, Shannon M. Meppelink, Rachael F. Lane, Angela Schmoldt, Aurash Mohaimani, Olaf Mueller, Rebecca D. Klaper
Transcriptome Signatures Of Wastewater Effluent Exposure In Larval Zebrafish Vary With Seasonal Mixture Composition In An Effluent-Dominated Stream, Emma B. Meade, Luke R. Iwanowicz, Nicklaus Neureuther, Gregory H. Lefevre, Dana W. Kolpin, Hui Zhi, Shannon M. Meppelink, Rachael F. Lane, Angela Schmoldt, Aurash Mohaimani, Olaf Mueller, Rebecca D. Klaper
United States Geological Survey: Staff Publications
Wastewater treatment plant (WWTP) effluent-dominated streams provide critical habitat for aquatic and terrestrial organisms but also continually expose them to complex mixtures of pharmaceuticals that can potentially impair growth, behavior, and reproduction. Currently, few biomarkers are available that relate to pharmaceutical-specific mechanisms of action. In the experiment reported in this paper, zebrafish (Danio rerio) embryos at two developmental stages were exposed to water samples from three sampling sites (0.1 km upstream of the outfall, at the effluent outfall, and 0.1 km below the outfall) during base-flow conditions from two months (January and May) of a temperate-region effluent-dominated stream …