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Synthesis And Characterization Of New Benzimidazole-Nitrone Derivatives And Study Of Their Effect As Anti-Fungal, Meaad A. Fadel, Dawood S. Ali, Hanaa K. Mousa
Synthesis And Characterization Of New Benzimidazole-Nitrone Derivatives And Study Of Their Effect As Anti-Fungal, Meaad A. Fadel, Dawood S. Ali, Hanaa K. Mousa
Al-Qadisiyah Journal of Pure Science
New benzimidazole derivatives (benzimidazole-nitrone) were synthesized from the condensation of o-phenylene diamine with p-amino benzaldehyde in the presence of (P-TSOH\EtOH) then the benzimidazole compounds that containing an imine group were oxidized to obtain a nitrone group by used peracetic acid and identified by FT-IR, H1-NMR spectra, and elemental analysis. all compounds applied to the candida and aspergillus fungi gave a different result. The compounds have Ph, OH and N(CH3)2 groups as substituted in synthesized benzimidazole derivatives were showed reactivity as anti-fungal.