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Full-Text Articles in Theory and Algorithms
Exploration Of Feature Selection Techniques In Machine Learning Models On Hptlc Images For Rule Extraction, Bozidar-Brannan Kovachev
Exploration Of Feature Selection Techniques In Machine Learning Models On Hptlc Images For Rule Extraction, Bozidar-Brannan Kovachev
Honors Theses
Research related to Biology often utilizes machine learning models that are ultimately uninterpretable by the researcher. It would be helpful if researchers could leverage the same computing power but instead gain specific insight into decision-making to gain a deeper understanding of their domain knowledge. This paper seeks to select features and derive rules from a machine learning classification problem in biochemistry. The specific point of interest is five species of Glycyrrhiza, or Licorice, and the ability to classify them using High-Performance Thin Layer Chromatography (HPTLC) images. These images were taken using HPTLC methods under varying conditions to provide eight …
Improving Adjacency List Storage Methods For Polypeptide Similarity Analysis, Arianna Swensen
Improving Adjacency List Storage Methods For Polypeptide Similarity Analysis, Arianna Swensen
Honors Theses
Protein design is a complex biomolecular and computational problem. Working on increasingly large protein folding problems requires an improvement in current analysis methods available. This work first discusses various methods of protein design, including de novo protein design, which is the primary focus of this thesis. Then, a new approach utilizing a B+ tree to effectively store and query a graph of keys and vertices is proposed in order to store the number of times two polypeptides are considered to be similar. This approach is found to have a reduction in time complexity from current mapping methods and thus provides …