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Biomedical Ontologies For Parasite Research, Vinh Nguyen, Satya S. Sahoo, Priti Parikh, Todd Minning, Brent Weatherly, Flora Logan, Amit P. Sheth, Rick Tarleton
Biomedical Ontologies For Parasite Research, Vinh Nguyen, Satya S. Sahoo, Priti Parikh, Todd Minning, Brent Weatherly, Flora Logan, Amit P. Sheth, Rick Tarleton
Kno.e.sis Publications
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease or American trypanosomiasis, which is the leading cause of death in Latin America. The primary objective of this study is to create an ontology-driven information infrastructure to support parasite researchers in identifying gene knockout, vaccination, or drug targets for T. cruzi. This involves querying across multiple datasets from diverse sources, such as proteome, pathway, internal lab data, etc. that are often represented in heterogeneous formats. To address this, a multi-ontology parasite knowledge repository (PKR) is being created with an intuitive graphical query interface called Cuebee. The PKR is underpinned by …
Provenance Management In Parasite Research, Vinh Nguyen, Priti Parikh, Satya S. Sahoo, Amit P. Sheth
Provenance Management In Parasite Research, Vinh Nguyen, Priti Parikh, Satya S. Sahoo, Amit P. Sheth
Kno.e.sis Publications
The objective of this research is to create a semantic problem solving environment (PSE) for human parasite Trypanosoma cruzi. As a part of the PSE, we are trying to manage provenance of the experiment data as it is generated. It requires to capture the provenance which is often collected through web forms used by biologists to input the information about experiments they conduct. We have created Parasite Experiment Ontology (PEO) that represents provenance information used in the project. We have modified the back end which processes the data gathered from biologists, generates RDF triples and serializes them into the triple …