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Medicinal-Pharmaceutical Chemistry Commons™

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Series

1998

Articles 1 - 5 of 5

Full-Text Articles in Medicinal-Pharmaceutical Chemistry

Substituted Polythiophenes From Highly Reactive Zinc Reagents, Reuben D. Rieke Jan 1998

Substituted Polythiophenes From Highly Reactive Zinc Reagents, Reuben D. Rieke

Chemistry Department: Faculty Publications

A novel Zerovalent zinc species and an organozinc reagent are disclosed. The zerovalent zinc species is directly pro duced by reaction of a reducing agent on a zinc salt, preferably Zn(CN)2. The organozinc reagent results from the reaction of the zerovalent zinc species and an organic compound having one or more stable anionic leaving groups. These organozinc reagents include a wide spectrum of functional groups in the organic radical, and are useful in a variety of reactions schemes.

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Cross-Coupling Of Organic Compounds Using Cuprous Odide, Reuben D. Rieke Jan 1998

Cross-Coupling Of Organic Compounds Using Cuprous Odide, Reuben D. Rieke

Chemistry Department: Faculty Publications

Cross-coupling or addition reactions of organic compounds, including acid halides, allylic halides, and C.B-unsaturated carbonyl containing compounds, with organozinc com pounds may be readily and Safely carried out in the presence of cuprous iodide. The use of this catalyst in the coupling reaction provides for the preparation of commercially useful products in the pharmaceutical, agrochemical and other industries.

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Metathesis-Based Synthesis Of Jasmonate And Homojasmonate Lactones, Candidates For Extracellular Quorum Sensing Molecules In Candida Albicans, Su C. Cho, Patrick Dussault, Amber D. Lisec, Ellen C. Jensen, Kenneth W. Nickerson Jan 1998

Metathesis-Based Synthesis Of Jasmonate And Homojasmonate Lactones, Candidates For Extracellular Quorum Sensing Molecules In Candida Albicans, Su C. Cho, Patrick Dussault, Amber D. Lisec, Ellen C. Jensen, Kenneth W. Nickerson

Chemistry Department: Faculty Publications

Ring-closing metathesis of jasmonate esters is shown to provide a rapid entry to jasmonate lactones. The lactones were investigated as possible quorum sensing molecules for the fungi Candida albicans. Assays demonstrated no effect on fungal morphology at concentrations up to 96 mM.

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Method For The Synthesis Of Α-Oxranyl Amino Acids, David B. Berkowitz, Michelle L. Pedersen Jan 1998

Method For The Synthesis Of Α-Oxranyl Amino Acids, David B. Berkowitz, Michelle L. Pedersen

Chemistry Department: Faculty Publications

The present invention is related to a novel class of decar-boxylase enzyme inhibitors consisting of α-oxiranyl amino acids and derivatives thereof and a method of synthesizing Such compounds.

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Pyrrolic Compounds, Michael J. Therien, Stephen Dimagno Jan 1998

Pyrrolic Compounds, Michael J. Therien, Stephen Dimagno

Chemistry Department: Faculty Publications

Novel methylpyrroles are provided, as well as processes for their preparation.

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