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Medicinal-Pharmaceutical Chemistry Commons™
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University of Nebraska - Lincoln
Department of Chemistry: Dissertations, Theses, and Student Research
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Uses Of Diaryliodonium Salts And Methods For Their Synthesis, Jordan M. Veness
Uses Of Diaryliodonium Salts And Methods For Their Synthesis, Jordan M. Veness
Department of Chemistry: Dissertations, Theses, and Student Research
Diaryliodonium salts have been studied continuously since the first report of their synthesis in 1894. Diaryliodonium salts are I(III) derivatives that are air- and moisturestable. The reactivity of these compounds resembles the organometallic chemistry of heavy transition metal ions such as Pb(IV), Hg(II), Th(III), and Pd(II). A significant advantage of diaryliodonium salts is that they can carry undergo many of the aryl functionalization reactions of heavy metal organometallic complexes, yet they have little to no toxicity and they are relatively inexpensive to prepare. The DiMagno laboratory uses diaryliodonium salts as precursors in the final synthetic step of radiopharmaceuticals; given that …