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Full-Text Articles in Materials Chemistry
Polymer-Based Nanotherapeutics To Combat Difficult-To-Treat Bacterial Infections, Jessa Marie V. Makabenta
Polymer-Based Nanotherapeutics To Combat Difficult-To-Treat Bacterial Infections, Jessa Marie V. Makabenta
Doctoral Dissertations
The continuous emergence and spread of antibiotic-resistant bacteria are a global health emergency, debilitating the capability to prevent and cure various infectious diseases that were once treatable. Antibiotic therapy is further rendered ineffective due to biofilm formation and the ability of bacteria to thrive and colonize inside mammalian cells. Given the diminishing efficacy of available antibiotics combined with the scarcity of new therapeutics entering the antibiotic pipeline, innovative treatment strategies are urgently in demand. Nanomaterial-based strategies offer ‘outside of the box’ approach for the treatment of antibiotic-resistant bacterial infections. Nanomaterials feature tunable physicochemical properties that can be carefully modified to …
Design Of Resposive Oligomeric And Polymeric Interfaces For Sensing And Controlled Release Applications, . Manisha
Doctoral Dissertations
Nature has designed magnificent responsive systems by constructing several interacting molecular level networks for the recognition and propagation of chemical and biochemical information. One of the eminent characteristics of these systems is their capability to quickly transduce molecular scale recognition events into macroscopic or visually observable responses. Inspired by these systems present in nature, we became interested in developing artificial responsive systems with similar capabilities. This dissertation will feature four such systems that employ amphiphilic oligomers and polymers which were chosen as the scaffolds because of their high thermodynamic stability, low critical aggregation concentrations, convenient handles to incorporate functional group …
Photothermal And Photochemical Strategies For Lightinduced Shape-Morphing Of Soft Materials, Alexa Simone Kuenstler
Photothermal And Photochemical Strategies For Lightinduced Shape-Morphing Of Soft Materials, Alexa Simone Kuenstler
Doctoral Dissertations
Engineering materials with the capability to transform energy from photons into mechanical work is an outstanding technical challenge with implications across myriad disciplines. Despite decades of work in this area, comprehensive understanding of how to prescribe shape change and work output in photoactive systems remains limited. To this end, this dissertation explores strategies to assemble photothermal and photochemical moieties in soft material systems to fabricate photoaddressable devices capable of specific shape changes upon illumination. Chapters 2 and 3 describe a methodology for spatially patterning plasmonic nanoparticles in liquid crystal elastomer fibers and sheets to specify local photothermally-induced strain profiles. Using …
Modification Of 2d Materials Utilizing Functional Polymer Interfacial Layers, Ryan Selhorst
Modification Of 2d Materials Utilizing Functional Polymer Interfacial Layers, Ryan Selhorst
Doctoral Dissertations
This dissertation describes the modification of 2D transition metal dichalcogenides (TMDCs). These materials exhibit unique electronic properties, ranging from metallic to insulating, and can transport either electrons (n-type) or holes (p-type). Polymers containing electronically-active moieties offer a path to control the electronic properties of a 2D material without altering the inherent structure of the semiconductor. This dissertation focuses on the synthesis of polymers bearing chalcogen-rich or zwitterionic moieties to alter the electronic and solution properties of 2D materials. Chapter 2 describes polymers containing sulfur-rich tetrathiafulvalene (TTF) and their effects as electroactive coatings on the TMDC molybdenum disulfide (MoS2). …
Design, Synthesis, And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies, Rajasekhar Reddy Rami Reddy
Design, Synthesis, And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies, Rajasekhar Reddy Rami Reddy
Doctoral Dissertations
Supramolecular nanoassemblies capable of reducing non-specific interactions with biological macromolecules, such as proteins, are of great importance for various biological applications especially for targeted drug delivery therapeutics. Recently, zwitterionic materials have been shown to reduce non-specific interactions with biomolecules, owing both to their charge neutrality and their ability to form strong hydration layer around zwitterions via electrostatic interactions. This dissertation focuses on design, synthesis, thorough characterization, and applications of zwitterionic amphiphilic dendrimers and polymeric materials. Firstly, A new triazole-based zwitterionic moiety was conceived and incorporated as the hydrophilic functionality in facially amphiphilic dendrons. Self-assembly characteristics and the structural and functional …