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Full-Text Articles in Inorganic Chemistry
Modulation Of Water-Exchange Rates Of Lanthanide(Iii)-Containing Complexes Using Polyethylene Glycol, Buddhima Nirodhi Siriwardena-Mahanama
Modulation Of Water-Exchange Rates Of Lanthanide(Iii)-Containing Complexes Using Polyethylene Glycol, Buddhima Nirodhi Siriwardena-Mahanama
Wayne State University Dissertations
MODULATION OF WATER-EXCHANGE RATES OF LANTHANIDE(III)-CONTAINING COMPLEXES USING POLYETHYLENE GLYCOL
by
BUDDHIMA N. SIRIWARDENA-MAHANAMA
May 2014
Advisor: Dr. Matthew J. Allen
Major: Chemistry
Degree: Doctor of Philosophy
A modular system of lanthanide(III)-containing polyethylene glycol (PEG) conjugates was synthesized and characterized to investigate the influence of length and density of PEG on water-exchange rates of lanthanide(III)-containing complexes. The water-exchange rates of lanthanide(III)-containing complexes contribute to the efficiency of these complexes as T1-shortening and paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents for magnetic resonance imaging (MRI). Because the mechanism of these two MRI methods is vastly different, there is …