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Full-Text Articles in Inorganic Chemistry
Isoquinoline-Derivatized Tris(2-Pyridylmethyl)Amines As Fluorescent Zinc Sensors With Strict Zn2+/Cd2+ Selectivity, Shawn Burdette, Yuji Mikata, Keiko Kawata, Saaya Takeuchi, Kaori Nakanishi, Hideo Konno, Saori Itami, Keiko Yasuda, Satoshi Tamotsu
Isoquinoline-Derivatized Tris(2-Pyridylmethyl)Amines As Fluorescent Zinc Sensors With Strict Zn2+/Cd2+ Selectivity, Shawn Burdette, Yuji Mikata, Keiko Kawata, Saaya Takeuchi, Kaori Nakanishi, Hideo Konno, Saori Itami, Keiko Yasuda, Satoshi Tamotsu
Shawn C. Burdette
Tris(2-pyridylmethyl)amine-based fluorescent ligands, N,N-bis(1-isoquinolylmethyl)-2-pyridylmethylamine (1-isoBQPA) and N,N-bis(7-methoxy-1-isoquinolylmethyl)-2-pyridylmethylamine (7-MeO-1-isoBQPA), have been prepared and the Zn2+-induced fluorescence enhancement has been investigated. Upon excitation at 324 nm, 1-isoBQPA exhibits a very weak emission (ϕ = [similar]0.010) in DMF–H2O (1 : 1). Upon Zn2+ addition, the 1-isoBQPA fluorescence increases (ϕZn = 0.055) at 357 nm and 464 nm. The fluorescence enhancement at longer wavelengths is Zn2+-specific, whereas Cd2+ induces a small emission increase at 464 nm (ICd/I0 = 1.1, ICd/IZn = 14%). The Zn2+/Cd2+ selectivity of the fluorescent response correlates with the Cd–Nisoquinoline and Zn–Nisoquinoline bond distances measured in the crystal structures. Introduction of …
Bis(2-Quinolylmethyl)Ethylenediaminediacetic Acids (Bqendas), Tqen–Edta Hybrid Molecules As Fluorescent Zinc Sensors, Shawn Burdette, Yju Mikata, Saaya Takeuchi, Hideo Konno, Satoshi Iwatsuki, Sakiko Akaji, Ikuko Hamagami, Masato Aoyama, Keiko Yasuda, Satoshi Tamotsu
Bis(2-Quinolylmethyl)Ethylenediaminediacetic Acids (Bqendas), Tqen–Edta Hybrid Molecules As Fluorescent Zinc Sensors, Shawn Burdette, Yju Mikata, Saaya Takeuchi, Hideo Konno, Satoshi Iwatsuki, Sakiko Akaji, Ikuko Hamagami, Masato Aoyama, Keiko Yasuda, Satoshi Tamotsu
Shawn C. Burdette
Molecular hybrids of TQEN (N,N,N′,N′-tetrakis(2-quinolylmethyl)ethylenediamine) and EDTA (ethylenediamine-N,N,N′,N′-tetraacetic acid) were examined as fluorescent Zn2+ sensors. Upon the addition of Zn2+, N,N-BQENDA (N,N-bis(2-quinolylmethyl)ethylenediamine-N′,N′-diacetic acid, 1a) exhibits a 30-fold emission enhancement at 456 nm (λex = 315 nm, ϕZn = 0.018) in buffer (HEPES, pH = 7.5, 100 mM KCl). The fluorescence enhancement is Zn2+-specific as Cd2+ induces much smaller increases (ICd/I0 = 5 and ICd/IZn = 16%). These spectroscopic properties, as well as the excellent water-solubility, represent a significant improvement compared to the parent TQEN sensor (ϕZn = 0.007, ICd/IZn = 64%). The isoquinoline analog N,N-1-isoBQENDA (N,N-bis(1-isoquinolylmethyl)ethylenediamine-N′,N′-diacetic acid, 1b) possesses a …
Quantifying Factors That Influence Metal Ion Release In Photocaged Complexes Using Zincast Derivatives, Shawn Burdette
Quantifying Factors That Influence Metal Ion Release In Photocaged Complexes Using Zincast Derivatives, Shawn Burdette
Shawn C. Burdette
Two generations of nitrobenzhydrol-based photocages for Zn2+ have been prepared and characterized. The first series includes the tridentate ZinCast-1 utilizes a bis-pyridin-2-ylmethyl-aniline ligand that forms a 5,5-chelate ring upon metal binding. The related photocages ZinCast-2 with a N-[2-(pyridine-2-yl)ethyl]-N-(pyridine-2-ylmethyl)aniline (5,6-chelate ring) and ZinCast-3 with a N,N-bis[2-(pyridine-2-yl)ethyl]aniline (6,6-chelate ring) were synthesized for comparative studies. The complexes formed by the ions Cu2+, Zn2+ and Cd2+ with three ZinCast and their photoproducts (ZinUnc) were interrogated by UV-Vis spectroscopy. The studies indicate that ZinCast-1 forms complexes of the highest stability and ZinCast-3 exhibits the most significant changes in metal affinity upon uncaging. These results suggest …