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Full-Text Articles in Analytical Chemistry
Quantitative Analysis Of Acetylsalicylic Acid By Q-Nmr (Quantitative-Nuclear Magnetic Resonance Spectroscopy), Charles Flemming Jr.
Quantitative Analysis Of Acetylsalicylic Acid By Q-Nmr (Quantitative-Nuclear Magnetic Resonance Spectroscopy), Charles Flemming Jr.
All Student Theses
Quantitative analysis is an important step during pharmaceutical drug development. Currently, the pharmaceutical industry uses high performance liquid chromatography (HPLC) for quantitative analysis of organic compounds as the preferred technique. The proton nuclear magnetic resonance (NMR) technique has an inherent ability to quantify a given analyte and may be used to quantify organic compounds. Quantitative nuclear magnetic resonance spectroscopy (q-NMR) of acetylsalicylic acid (ASA) was conducted using tert-butyl alcohol (tert-butanol) as the internal standard and deuterated chloroform (CDCl3) as the solvent. Preparations of ASA solutions in low and high concentration ranges, 1.0 mM – 10.1 …