Analytical Chemistry Commons^™

Chemometric And Bioinformatic Analyses Of Cellular Biochemistry, Bradley Worley

Department of Chemistry: Dissertations, Theses, and Student Research

The amount of information collected and analyzed in biochemical and bioanalytical research has exploded over the last few decades, due in large part to the increasing availability of analytical instrumentation that yields information-rich spectra. Datasets from Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), infrared (IR) or Raman spectroscopy may easily carry tens to hundreds of thousands of potentially correlated variables observed from only a few samples, making the application of classical statistical methods inappropriate, if not impossible. Drawing useful biochemical conclusions from these unique sources of data requires the use of specialized multivariate data handling techniques.

Unfortunately, proper implementation of …

Study Of The Secondary Metabolites Of Black Aspergilli From Canadian Vineyards, Tianyu Qi

Electronic Thesis and Dissertation Repository

Ochratoxin A (OTA) and fumonisin are mycotoxins produced by black Aspergilli that contaminate wine in many countries around the world. Both OTA and fumonisins are possible carcinogens to humans. There is limited data about the occurrence of OTA and fumonisins in Canadian vineyards. Therefore, a survey of the black Aspergilli from 2012-2014 has been conducted. In the mycotoxin study, high performance liquid chromatography-mass spectrometry was used to screen and quantify OTA and fumonisins from both black Aspergilli isolated on artificial media and grape samples. OTA was only detected from one fungal isolate and not on any grapes. Fumonisin B_{2 …}