Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Environmental Chemistry (2)
- Organic Chemistry (2)
- Physical Chemistry (2)
- Atmospheric Sciences (1)
- Biochemistry (1)
-
- Biochemistry, Biophysics, and Structural Biology (1)
- Biogeochemistry (1)
- Civil and Environmental Engineering (1)
- Cosmochemistry (1)
- Earth Sciences (1)
- Engineering (1)
- Environmental Engineering (1)
- Environmental Sciences (1)
- Life Sciences (1)
- Oceanography and Atmospheric Sciences and Meteorology (1)
- Systems Biology (1)
Articles 1 - 3 of 3
Full-Text Articles in Analytical Chemistry
Aqueous Photochemistry Of Glyoxylic Acid, Alexis J. Eugene, Sha-Sha Xia, Marcelo I. Guzman
Aqueous Photochemistry Of Glyoxylic Acid, Alexis J. Eugene, Sha-Sha Xia, Marcelo I. Guzman
Chemistry Faculty Publications
Aerosols affect climate change, the energy balance of the atmosphere, and public health due to their variable chemical composition, size, and shape. While the formation of secondary organic aerosols (SOA) from gas phase precursors is relatively well understood, studying aqueous chemical reactions contributing to the total SOA budget is the current focus of major attention. Field measurements have revealed that mono-, di-, and oxo-carboxylic acids are abundant species present in SOA and atmospheric waters. This work explores the fate of one of these 2-oxocarboxylic acids, glyoxylic acid, which can photogenerate reactive species under solar irradiation. Additionally, the dark thermal aging …
Photocatalytic Reduction Of Fumarate To Succinate On Zns Mineral Surfaces, Ruixin Zhou, Marcelo I. Guzman
Photocatalytic Reduction Of Fumarate To Succinate On Zns Mineral Surfaces, Ruixin Zhou, Marcelo I. Guzman
Chemistry Faculty Publications
The reductive tricarboxylic acid (rTCA) cycle is an important central biosynthetic pathway that fixes CO2 into carboxylic acids. Among the five reductive steps in the rTCA cycle, the two-electron reduction of fumarate to succinate proceeds nonenzymatically on the surface of photoexcited sphalerite (ZnS) colloids suspended in water. This model reaction is chosen to systematically study the surface photoprocess occurring on ZnS in the presence of [Na2S] (1–10 mM) hole scavenger at 15 °C. Experiments at variable pH (5–10) indicate that monodissociated fumaric acid is the primary electron acceptor forming the monoprotic form of succinic acid. The following …
Determination Of Mln0128, An Investigational Antineoplastic Agent, In Human Plasma By Lc–Ms/Ms, Sandeep R. Kunati, Yan Xu
Determination Of Mln0128, An Investigational Antineoplastic Agent, In Human Plasma By Lc–Ms/Ms, Sandeep R. Kunati, Yan Xu
Chemistry Faculty Publications
MLN0128, an mTOR kinase inhibitor, is currently undergoing clinical investigation for treatment of a variety of cancers. To support this work, an LC–MS/MS method has been developed for the determination of MLN0128 in human plasma. A structural analog STK040263 was used as the internal standard. Both MLN0128 and the IS were first extracted from plasma using methyl tert-butyl ether; then separated on a Waters XTerra® MS C18 column using a mobile phase consisting of methanol–acetonitrile–10.0 mm ammonium formate (34:6:60, v/v/v) at a flow rate of 0.300 mL min−1. Quantitation of MLN0128 was done by positive electrospray ionization tandem mass spectrometry …