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Full-Text Articles in Analytical Chemistry
Development Of Improved Extraction/Purification Methods And Comprehensive Screening/Confirmation By Lc-Qqq-Ms Analysis For Novel Psychoactive Substances, Ashley N. Kimble
Development Of Improved Extraction/Purification Methods And Comprehensive Screening/Confirmation By Lc-Qqq-Ms Analysis For Novel Psychoactive Substances, Ashley N. Kimble
FIU Electronic Theses and Dissertations
The presence of novel psychoactive substances (NPS) in forensic casework poses major difficulties for detection, since there are many structural variations of NPS circulating in the street market. There are currently no comprehensive screening/confirmatory/quantitation methods available that encompass the majority of NPS encountered in forensic toxicology. A major issue faced with developing such a method is that full validation is extremely time consuming. The use of a liquid chromatography triple quadrupole tandem mass spectrometry (LC-QqQ-MS/MS) method makes the detection of a large number of NPS possible because of high selectivity and sensitivity.
This research included four main tasks: 1) development …