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Full-Text Articles in Chemistry
Investigations On The Active Catalyst In Pd Catalyzed Organic Reactions, Riley Mcgraw
Investigations On The Active Catalyst In Pd Catalyzed Organic Reactions, Riley Mcgraw
WWU Honors College Senior Projects
Cross coupling and C-H functionalization reactions are valuable tools in the synthesis of pharmaceuticals, natural products, fine chemicals, and electronics. Molecular precatalysts are frequently used in both reactions but because the reactions use conditions like those employed in intentional preparation of nanoparticles, the presence of nanoparticles is highly likely for both systems. In the case of the cross-coupling reaction, nanoparticles have been shown to have catalytic relevance, but C-H functionalization reactions are widely thought to occur by means of a homogenous catalyst. To better understand the state of the active catalyst, a method of homogeneity analysis by centrifuge is proposed. …
Class A Sortases: Structures And Alternative Substrate Binding And Cleavage, Brandon Vogel
Class A Sortases: Structures And Alternative Substrate Binding And Cleavage, Brandon Vogel
WWU Graduate School Collection
Sortases, consisting of classes A-F, are cysteine transpeptidases found in the cell wall of Gram-positive bacteria. They play a crucial role in ligating proteins to the cell wall that are responsible for cell adhesion, immune evasion, host cell invasion, and nutrient acquisition through a transpeptidation reaction. Consequently, they are an attractive therapeutic target. Class A sortases are also utilized in protein engineering applications such as sortase-mediated ligations and sortagging. Despite extensive research in the past two decades, gaps persist in understanding how class A sortases recognize their substrates, primarily due to a lack of structural information on sortases non-covalently bound …
Indium Oxide-Based Catalysts For Solar Fuel Generation, Ryan Hagmann
Indium Oxide-Based Catalysts For Solar Fuel Generation, Ryan Hagmann
WWU Honors College Senior Projects
The need to pursue renewable, carbon neutral forms of energy has led to a far reaching-research effort to generate and store solar energy. It has been shown that indium oxide-based catalysts have the potential to reduce carbon dioxide to carbon monoxide or even continue reduction to methanol. Recent advances and current challenges in further developing indium oxide catalysis as a means of producing a sustainable liquid fuel supply will be addressed. This project will give an overview of the research in indium oxide catalysts for solar fuels generation and the immediate relevance of recent work within the Bussell Research Group …
Gold Catalyzed Lactonization Of Epoxide Esters, Carlos Enciso Lopez
Gold Catalyzed Lactonization Of Epoxide Esters, Carlos Enciso Lopez
Scholars Week
Lactones are cyclic esters of varying ring size that occur naturally in organic compounds. Organic structures such as these have various useful biological activities applicable to antibacterial drugs, potential anticancer drugs, and participants of metabolic processes. Gold catalysts Au(I) and Au(III) are shown in our experiments to be effective in inducing intramolecular lactonization of epoxide esters to form desired lactone products. In our experiments gold catalysts coordinated with epoxides to develop a positive charge on the carbon nearest to the carbonyl. The result is an intramolecular lactonization of the ester via nucleophilic attack of the carbonyl oxygen onto the positive …