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Full-Text Articles in Chemistry
Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier
Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier
LSU Doctoral Dissertations
Over the last few decades, liposomes have generated a lot of interest as drug delivery vehicles to address the need for providing both increased therapeutic efficacy and decreased systemic exposure, simultaneously. The challenge of increasing drug accumulation at diseased sites, without compromising the integrity and stability of the liposomal carrier during circulation, has been met with two possible solutions: (1) active targeting and (2) active triggering. To achieve selective and site-specific delivery of drugs to tumors, active triggering methods have been developed wherein a responsive element is incorporated into the liposomal bilayer, which causes destabilization of the liposome upon exposure …
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
LSU Doctoral Dissertations
Liposomes have had a long and fruitful application of drug delivery devices in the treatment of select tumors and cancer types. Third-generation liposomes possess endogenous triggering methods that hold the ability for site-specific unloading of liposomal contents, thus providing necessary temporal and spatial control over contents release that can be tuned to match the drug efficacy for decreased side effects during treatment. Of these new endogenous triggers, redox-active liposomes that can be triggered to unload contents via two-electron reduction by enzymes or chemical means have demonstrated promise for the encapsulation and delivery of cargo. The research project undertaken involved the …