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- Liposomes (3)
- Microfluidics (3)
- Atomic force microscopy (2)
- DNA analysis (2)
- Drug delivery (2)
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- Magnetism (2)
- Quinones (2)
- Redox (2)
- Scanning probe microscopy (2)
- AFM (1)
- Adhesive (1)
- Alligator mississippiensis (1)
- Alu elements (1)
- Alumides (1)
- Amyloid Beta Peptide (1)
- Antimicrobial Peptides (1)
- BNCT (1)
- Block copolymers (1)
- Breast cancer (1)
- CTCs (1)
- Capillary Electrophoresis (1)
- Chemical oxidation (1)
- Combustion (1)
- Conjugated polymer thin film (1)
- Conjugated polymers (1)
- Continuous flow PCR (1)
- Corrosion (1)
- Crystal Growth (1)
- Cyclic voltammetry (1)
- DIAGNOSTICS OF STROKE (1)
Articles 1 - 26 of 26
Full-Text Articles in Chemistry
Synthesis Of Oligopeptide Fragments For An Skp1 Mimetic, Jarret Curtis
Synthesis Of Oligopeptide Fragments For An Skp1 Mimetic, Jarret Curtis
Honors Theses
No abstract provided.
Oxidative Derivatization Of Folic Acid Monitored By Capillary Electrophoresis With Uv Absorbance And Fluorescence Detection, Jeffrey P. Cunniff
Oxidative Derivatization Of Folic Acid Monitored By Capillary Electrophoresis With Uv Absorbance And Fluorescence Detection, Jeffrey P. Cunniff
Honors Theses
No abstract provided.
Surface-Initiated Polymerization As A Novel Strategy Towards Preparation Of Organic Semiconducting Polymer Thin Films, Euiyong Hwang
Surface-Initiated Polymerization As A Novel Strategy Towards Preparation Of Organic Semiconducting Polymer Thin Films, Euiyong Hwang
LSU Doctoral Dissertations
Organic semiconducting polymer thin films are core materials for organic electronics that are conventionally prepared by solution processing techniques. Despite having the advantage of easy and fast thin film manufacturing, solution techniques have intrinsic drawbacks, such as disordered and poor molecular organization in the film (often resulting in poor device performance), as well as insufficient stabilities of the films and resulting devices. To improve this situation, we designed a novel “bottom-up” fabrication of surface-immobilized organic semiconducting thin films through in situ polymerization. This new strategy will allow high degree of control over molecular organization which therefore results in improved free …
Transport Properties Of Nanometer-Sized Assemblies Through Nanofluidic Channels With Single Entity Electrical Detection, Franklin Ifeanyichukwu Uba
Transport Properties Of Nanometer-Sized Assemblies Through Nanofluidic Channels With Single Entity Electrical Detection, Franklin Ifeanyichukwu Uba
LSU Master's Theses
Recently, there have been reports on biological and solid-state nanopores that identify single biopolymers or their constituent monomers by analyzing changes in ionic current blockades when they block the flux of buffer ions while travelling through the nanopores. Nevertheless, there have been several limitations in their application, especially as DNA detectors; Poor confinement of the DNA strand within the nanopore (~0.1 % of a 10 kilobase (kb) DNA), poor signal sensitivity and random motion experienced by the DNA in solution that results in a large amount of noise in the signal. These have led to the development of nanochannel-based devices, …
Semiconducting Polymers And Block Copolymers Prepared By Chain-Growth Living Polymerization, Jinwoo Choi
Semiconducting Polymers And Block Copolymers Prepared By Chain-Growth Living Polymerization, Jinwoo Choi
LSU Doctoral Dissertations
Organic semiconducting polymers are the unique materials that considered a basis for the next generation of electronic and optoelectronic applications. However, high device performance of semiconducting polymers strongly depends on their molecular structure and nanoscale organization. Therefore, it is an essential task to develop robust and versatile synthetic approaches to build such well-defined semiconducting polymer materials. This Ph.D. study aimed at design of state-of-the-art synthetic approaches towards organic semiconducting polymers via chain-growth living polymerization as well as development of polymer architectures which can self-organize into supramolecular nanoassemblies or allow external control of the polymer’s properties. First, we prepared a series …
Selection And Enumeration Of Low Epcam Expressing Breast Cancer Ctcs Using A High Throughput Microfluidic Device, Brandy Charon Snowden
Selection And Enumeration Of Low Epcam Expressing Breast Cancer Ctcs Using A High Throughput Microfluidic Device, Brandy Charon Snowden
LSU Master's Theses
Breast cancer cells overexpress EpCAM that can be used as a marker to select breast cancer CTCs from heterogeneous clinical samples, even when present in low abundance. This study used MDA-MB-231 cells which have a low expression level of EpCAM (1.7 x 103 binding sites per cell.3) Herein, we will report on the use of antiEpCAM antibodies immobilized onto the surface of a capture bed poised within a PMMA microchip that was fabricated into an HTMSU used for selection of breast cancer CTCs seeded into a buffer solution. The microchannel walls within the capture bed were UV modified for 5, …
Application Of Scanning Probe Microscopy For New Physical Measurements And Studies Of Surface Chemical Reactions Of Materials At The Molecular Level, Stephanie Loletha Daniels
Application Of Scanning Probe Microscopy For New Physical Measurements And Studies Of Surface Chemical Reactions Of Materials At The Molecular Level, Stephanie Loletha Daniels
LSU Doctoral Dissertations
Scanning probe microscopy (SPM) provides unique capabilities for surface visualization and measurements that reach atomic and molecular dimensions. My research focus is directed toward applying and developing new measurements for analytical and surface chemistry with SPM. Two distinct goals based on studies with atomic force microscopy (AFM) will be described within this dissertation. The primary goal was to develop and apply a new AFM imaging mode for ultrasensitive measurements of the superparamagnetic properties of proteins. Magnetic sample modulation (MSM)-AFM, has capabilities to investigate and map the magnetic response of nanomaterials with unprecedented spatial resolution. The second goal was to apply …
Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier
Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier
LSU Doctoral Dissertations
Over the last few decades, liposomes have generated a lot of interest as drug delivery vehicles to address the need for providing both increased therapeutic efficacy and decreased systemic exposure, simultaneously. The challenge of increasing drug accumulation at diseased sites, without compromising the integrity and stability of the liposomal carrier during circulation, has been met with two possible solutions: (1) active targeting and (2) active triggering. To achieve selective and site-specific delivery of drugs to tumors, active triggering methods have been developed wherein a responsive element is incorporated into the liposomal bilayer, which causes destabilization of the liposome upon exposure …
Cure-On Demand Wood Adhesives Using Frontal Polymerization Of Acrylates, Treyvon Holt
Cure-On Demand Wood Adhesives Using Frontal Polymerization Of Acrylates, Treyvon Holt
LSU Master's Theses
Frontal polymerization (FP) is when the monomer is polymerized by a zone of reaction propagating through the monomer. The reaction zone is fueled by the heat given off by the polymerization of the monomer. FP is a promisig method for curing adhesives because it allows for cure-on-demand and fast cure times. The monomers selected for the adhesive is the main factor in determining the adhesive’s properties. Trimethylolpropane triacrylate (TMPTA), pentaerythritol tetraacrylate (PETA), and other multifunctional monomers make the polymer formed more brittle. The brittleness can be reduced by using trimethylolpropane ethoxylate triacrylates (TMPEOTA) in the place of the other multifunctional …
Exotic Ground States: A Study In The Structural Effects On Frustration And Dimensionality, Melissa C. Menard
Exotic Ground States: A Study In The Structural Effects On Frustration And Dimensionality, Melissa C. Menard
LSU Doctoral Dissertations
Structural disorder and dimensionality play central roles in the characterization of structure and properties of crystalline materials. Although structural disorder is commonly considered an undesirable quality, structural disorder may be desirable when searching for new materials with exotic properties. Disorder can be used as a tunable parameter when considering atomic sizes, coordination preferences, and electronegativity differences can be varied by substituting elements into a given structure. Dimensionality can be viewed as another adjustable parameter when searching for new materials presenting unique challenges when characterizing new materials. One way to tune dimensionality is by chemical doping to affect coupling between layers/chains. …
Integrated Modular Microfluidic System For Forensic Alu Dna Typing, Samuel Kimani Njoroge
Integrated Modular Microfluidic System For Forensic Alu Dna Typing, Samuel Kimani Njoroge
LSU Doctoral Dissertations
Driven by the numerous applications of genome-related research, fully integrated microfluidic systems have been developed that have advanced the capabilities of molecular and, in particular, genetic analyses. A brief overview on integrated microfluidic systems for DNA analysis is given in Chapter 1 followed by a report on micro-capillary electrophoresis (µCE) of Alu elements with laser-induced fluorescence (LIF) detection, in which the monomorphic Alu insertions on the X and Y chromosomes were utilized to detect male DNA in large female DNA background (Y: X = 1:19) without cell sorting prior to the determination. The polymorphic Alu loci with known restricted geographical …
Proteomic Analysis Of The Blood Of Alligator Mississippiensis, Lancia Nadinia Fallen Darville-Bowleg
Proteomic Analysis Of The Blood Of Alligator Mississippiensis, Lancia Nadinia Fallen Darville-Bowleg
LSU Doctoral Dissertations
My research focus was to investigate alligator blood using mass spectrometry-based proteomics methods to understand their innate immune systems. The first goal was to sequence peptides and proteins from the blood serum and leukocytes using tandem mass spectrometry and de novo sequencing. The second goal was to determine the function of these biological molecules and their relationship to the immune system. One- and two-dimensional gel electrophoresis was used to separate proteins from alligator leukocytes, which were enzymatically digested. The peptides were measured using reversed phase nano-high performance liquid chromatography coupled with tandem mass spectrometry (nano-HPLC-MS/MS) followed with de novo sequencing. …
Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano
Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano
LSU Doctoral Dissertations
The formation of environmentally persistent free radicals in combustion system was investigated from chemisorptions of chlorine- and hydroxy-substituted benzenes on transition metal oxide surface under post-combustion conditions. This manuscript reports the formation of EPFRs on silica particles containing 5% Fe(III)2O3, Ni(II)O, and Zn(II)O. The EPFRs are formed by the chemisorption of substituted aromatic molecular adsorbates on the metal cation center followed by electron transfer from the adsorbate to the metal ion at temperatures from 150 to 400 oC. Depending on the nature of the adsorbate and the temperature, two organic EPFRs were formed: a phenoxyl-type radical, which has a lower …
Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza
Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza
LSU Doctoral Dissertations
For decades, there has been a lot of focus on the development of new carriers for drug delivery applications. From all of the carriers, stimuli-responsive liposomes have been studied extensively, but only a handful have been enzyme-responsive liposomes. Therefore, the field of endogenous proteins as activators of liposomes is a fertile field worthy of exploration. The research described in this dissertation involves how structural changes on the quinone moiety altered their electronic properties, as well as their behavior toward the human enzyme NAD(P)H:quinone oxidoreductase type-1 (hNQO1, over expressed in certain tumor tissues), thus yielding a series of triggerable quinones to …
Fabrication Of Organosilane Nanostructures As Selective Sites For Surface Chemical Reactions, Kathie Lee Lusker
Fabrication Of Organosilane Nanostructures As Selective Sites For Surface Chemical Reactions, Kathie Lee Lusker
LSU Doctoral Dissertations
Naturally self-assembled mesospheres provide a practical route for controlling the arrangement of materials on surfaces at the nanoscale. Periodic arrays of well-defined nanostructures can be produced with different nanomaterials and interpattern spacings. Results presented in this dissertation demonstrate particle lithography methods developed for fabricating arrays of organosilane nanostructures. Surfaces were designed for the selective deposition of polymers and nanoparticles to produce multicomponent nanopatterns. The approaches for surface patterning provide new directions for studying surface chemistry at the molecular-level, and have practical application for emerging photovoltaic thin film technologies. Atomic force microscopy (AFM) provides unique capabilities for molecular visualization and ultrasensitive …
Understanding The Selective Detection Of Homocysteine And Studies Toward The Synthesis Of Vinigrol, Dong Wang
Understanding The Selective Detection Of Homocysteine And Studies Toward The Synthesis Of Vinigrol, Dong Wang
LSU Doctoral Dissertations
The first part of the work is dedicated to the selective detection of Homocysteine (Hcy). In order to better understand this colorimetric detection method, a thermodynamic model for the pH dependence of the effective reduction potential of Hcy derived á-carbon radicals has been proposed. And using viologen indicators of varying reduction potentials, we demonstrate that colorimetric changes occur at experimental pH values consistent with the model. The one-carbon bridge stereochemistry of bicyclo[3.3.1]nonane framework is critical to make the third ring of the tricyclic precursor of vinigrol. We studied this stereochemistry carefully and found that the major diastereomer formed from Robinson …
Structure-Function Relationships In Poly(3-Hexylthiophene)S Formed Via Manipulation Of Oxidative Coupling Routes, Warren James Solfiell
Structure-Function Relationships In Poly(3-Hexylthiophene)S Formed Via Manipulation Of Oxidative Coupling Routes, Warren James Solfiell
LSU Doctoral Dissertations
This investigation focused on the analytical characterization of poly(3-hexylthiophene), a heterocyclic conducting polymer system, with an overall objective of elucidating the effects that the experimental conditions during chemical oxidation using iron(III) chloride as an oxidant impart on the structure of the resulting polymers. Poly(3-alkylthiophene)s are extensively studied materials due to their high electrical conductivities and unique optical properties that make them extremely valuable for use in contemporary technological applications and devices. Specifically, the aim of this research was to determine the dependence of structural characteristics, such as endgroups, molecular weights, and regioregularities, on the solvent employed for the reaction and …
Fully Integrated Microsystem For Bacterial Genotyping, Hui-Wen Chen
Fully Integrated Microsystem For Bacterial Genotyping, Hui-Wen Chen
LSU Doctoral Dissertations
Methods for bacterial detection and identification has garnered renewed interest in recent years due to the infections they may cause and the antimicrobial resistances they can develop, the potential for bioterrorism threats and possible contamination of food/water supplies. Therefore, the rapid, specific and accurate detection of pathogens is crucial for the prevention of pathogen-related disease outbreaks and facilitating disease management as well as the containment of suspected contaminated food and/or water supplies. In this dissertation an integrated modular-based microfluidic system composed of a fluidic cartridge and a control instrument has been developed for bacterial pathogen detection. The integrated system can …
Single-Molecule Detection And Microfluidics: Generating Systems For The In Vitro Diagnostics Of Stroke, Brandon M. Young
Single-Molecule Detection And Microfluidics: Generating Systems For The In Vitro Diagnostics Of Stroke, Brandon M. Young
LSU Master's Theses
There is currently no available molecular diagnostic test for stroke; the common modality for diagnosis consists of computed tomography or magnetic resonance imaging. Unfortunately, the use of these diagnostic regimens can delay proper therapeutic treatment, which requires administration within the first 3 h of a stroke event. We are developing a molecular assay that can report, in near real time and at the point-of-care, the presence or absence of biomarkers specifically targeted for the diagnosis of ischemic or hemorrhagic stroke. The proposed strategy uses blood-borne mRNAs that are either under-expressed or over-expressed as a result of tissue damage within the …
Synthesis, Biological And Photophysical Studies Of Novel Compounds For Cancer Therapy, Edith Khavwajira Amuhaya
Synthesis, Biological And Photophysical Studies Of Novel Compounds For Cancer Therapy, Edith Khavwajira Amuhaya
LSU Doctoral Dissertations
Cancer remains the second most common cause of death in the United States. It is therefore imperative that a lot of effort be put into finding a cure for this dreadful disease that shows no discrimination, and virtually anybody is at risk of developing the disease. Chapter 1 introduces basic facts about cancer and the available treatments, including PDT and BNCT. Our focus will be on these two bimodal therapies, which form the basis of my research work, which involves the synthesis of potential sensitizers to be used either in PDT or BNCT or both. In Chapter 2, I discuss …
Dynamic Measurements With Scanning Probe Microscopy: Surface Studies Using Nanostructured Test Platforms Of Metalloporphyrins, Nanoparticles And Amyloid Fibrils, Wilson K. Serem
LSU Doctoral Dissertations
A hybrid imaging mode for characterization of magnetic nanomaterials has been developed, using atomic force microscopy (AFM) combined with electromagnetic sample actuation. Instead of using a coated AFM probe as a magnetic sensor; our strategy is to use a nonmagnetic probe with contact mode AFM to characterize the vibration of magnetic and superparamagnetic nanomaterials responding to the flux of an AC electromagnetic field. We refer to the hybrid imaging mode as magnetic sample modulation (MSM-AFM). An oscillating magnetic field is produced by applying an AC current to a wire coil solenoid placed under the sample stage for tuning selected parameters …
Crystal Growth Of Complex Intermetallics In Search For Heavy Electron Systems, Brenton L. Drake
Crystal Growth Of Complex Intermetallics In Search For Heavy Electron Systems, Brenton L. Drake
LSU Doctoral Dissertations
The structural solution and physical property characterization of several Ln-T-Al/Ga and Ln-T-Al-Si contain phases, which include Ln(Cu,Al)12 (Ln = Y, Ce, Pr, Sm, and Yb), Ln(Ag,Al,Si)2 (Ln = Ce and Gd), LnCu2(Al,Si)5 (Ln = La and Ce), Ln(Cu,Al,Ga)13-x (Ln = La, Ce, Pr, and Eu), α and β LnNiGa4 (α Ln = Y and Gd – Yb; β Ln = (Tb – Er)), and Ln4FeGa12 (Ln = Tb – Er) will be presented in this work with an emphasis on crystal growth. The systems cover a large breadth of phase space and serve to illustrate the new and rich chemistry …
A Multifaceted Phenomenon Of Hydrophobic Effects: Insights Learned From Nucleation Algorithm Based Computer Simulation Approach, Hyunmi Kim
LSU Doctoral Dissertations
We have applied our new approach, a combination of the AVUS-HR nucleation algorithm and a thermodynamic cycle, to the studies of hydrophobicity-related researches. Due to the multifaceted characteristics of hydrophobicity, it is essential to acquire knowledge in various environments where hydrophobic relevant events occur for comprehensive understanding of this process. In this regards, we have chosen two relatively unstudied hydrophobic subjects for application of our new methodology. For the first subject, hydrophobic association behaviors of a methane pair confined into a nanometer sized hydrophobic cavity have been investigated. Our new approach demonstrates that the association behavior between two methane molecules …
Analysis Of Amyloid Beta (A [Beta]) Peptides By Capillary Electrophoresis And Laser-Induced Fluorescence Anisotropy Detection, Ryan Andrew Picou
Analysis Of Amyloid Beta (A [Beta]) Peptides By Capillary Electrophoresis And Laser-Induced Fluorescence Anisotropy Detection, Ryan Andrew Picou
LSU Doctoral Dissertations
The goal of the research presented in this dissertation is to develop laser-induced fluorescence anisotropy (LIFA) detection for detecting and characterizing amyloid beta (Aβ) peptide aggregates separated by capillary electrophoresis (CE). Senile plaques composed primarily of aggregated Aβ (1-40) and Aβ (1-42) peptides have been found in the brains of Alzheimer’s disease patients. These peptides are thought to be responsible for the disease pathology. A CE method using UV absorbance detection was developed for the quantification of Aβ (1-40) monomer and testing of Aβ monomer preparations for undesired aggregates (Chapter 2). Analyses of both Aβ (1-40) and Aβ (1-42) monomer …
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
LSU Doctoral Dissertations
Liposomes have had a long and fruitful application of drug delivery devices in the treatment of select tumors and cancer types. Third-generation liposomes possess endogenous triggering methods that hold the ability for site-specific unloading of liposomal contents, thus providing necessary temporal and spatial control over contents release that can be tuned to match the drug efficacy for decreased side effects during treatment. Of these new endogenous triggers, redox-active liposomes that can be triggered to unload contents via two-electron reduction by enzymes or chemical means have demonstrated promise for the encapsulation and delivery of cargo. The research project undertaken involved the …
Preparation And Studies Of Ratiometric Fluorescent Chemosensors Based On The Attenuation Of Excitation Energy Transfer, Jiba Raj Acharya
Preparation And Studies Of Ratiometric Fluorescent Chemosensors Based On The Attenuation Of Excitation Energy Transfer, Jiba Raj Acharya
LSU Doctoral Dissertations
Molecular devices possessing pi-electron conjugated scaffold demonstrate unique capabilities as fluorescent chemosensors for the trace detection of analytes in a variety of environments. Important properties of these compounds such as charge transport and exciton migration, emission intensity etc. can be simply attenuated by external stimuli or analyte binding, leading to considerable changes in observable signals. The main goal of this Ph.D. dissertation was to study the possibility to control excitation energy migration in conjugated systems. Towards this goal, we designed surface-immobilized monodispersed oligo(p-phenylene ethynylene)s (OPEs) as a general basis for thin-film ratiometric fluorescent chemosensors. The sensor molecules have been functionalized …