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Articles 31 - 38 of 38
Full-Text Articles in Chemistry
Detecting Zn(Ii) Ions In Live Cells With Near-Infrared Fluorescent Probes., Mingxi Fang, Shuai Xia, Jianheng Bi, Travis P Wigstrom, Loredana Valenzano, Jianbo Wang, Marina Tanasova, Rudy Luck, Haiying Liu
Detecting Zn(Ii) Ions In Live Cells With Near-Infrared Fluorescent Probes., Mingxi Fang, Shuai Xia, Jianheng Bi, Travis P Wigstrom, Loredana Valenzano, Jianbo Wang, Marina Tanasova, Rudy Luck, Haiying Liu
Michigan Tech Publications
Two near-infrared fluorescent probes (A and B) containing hemicyanine structures appended to dipicolylamine (DPA), and a dipicolylamine derivative where one pyridine was substituted with pyrazine, respectively, were synthesized and tested for the identification of Zn(II) ions in live cells. In both probes, an acetyl group is attached to the phenolic oxygen atom of the hemicyanine platform to decrease the probe fluorescence background. Probe A displays sensitive fluorescence responses and binds preferentially to Zn(II) ions over other metal ions such as Cd2+ ions with a low detection limit of 0.45 nM. In contrast, the emission spectra of probe B is …
Production Of Trimethylaluminum (Me3al) With Counterfeit Refrigerant Chloromethane (R-40), Reactivity Of Me3al With Refrigerant Oils And Methods To Deactivate Me3al, Zhichao Chen, Rudy Luck
Production Of Trimethylaluminum (Me3al) With Counterfeit Refrigerant Chloromethane (R-40), Reactivity Of Me3al With Refrigerant Oils And Methods To Deactivate Me3al, Zhichao Chen, Rudy Luck
Michigan Tech Publications
Reactions between Al containing materials and counterfeit refrigerant chloromethane (R-40) were investigated under various conditions. The addition of Mg effected a reaction indicating that trimethylaluminum may have been produced in the reaction. A different study involving Al-foil, AlCl3 and chloromethane resulted in cracks detected on the Al-foil which reduced in weight by 19% and methane was detected. Studies conducted either at room temperature or at 80°C with two other genuine refrigerants, R-142b (1-chloro-1,1-difluoroethane) and R-133a (2-chloro-1,1,1-trifluoroethane) did not form organoaluminum compounds. Several commercially available refrigerant oils were subjected to Me3Al. Only polyester oil resulted in a decrease …
Metabolism-Driven High-Throughput Cancer Identification With Glut5-Specific Molecular Probes, Srinivas Kannan, Vagarshak Begoyan, Joseph Fedie, Shuai Xia, Łukasz J. Weseliński, Marina Tanasova, Smitha Rao
Metabolism-Driven High-Throughput Cancer Identification With Glut5-Specific Molecular Probes, Srinivas Kannan, Vagarshak Begoyan, Joseph Fedie, Shuai Xia, Łukasz J. Weseliński, Marina Tanasova, Smitha Rao
Michigan Tech Publications
Point-of-care applications rely on biomedical sensors to enable rapid detection with high sensitivity and selectivity. Despite advances in sensor development, there are challenges in cancer diagnostics. Detection of biomarkers, cell receptors, circulating tumor cells, gene identification, and fluorescent tagging are time-consuming due to the sample preparation and response time involved. Here, we present a novel approach to target the enhanced metabolism in breast cancers for rapid detection using fluorescent imaging. Fluorescent analogs of fructose target the fructose-specific transporter GLUT5 in breast cancers and have limited to no response from normal cells. These analogs demonstrate a marked difference in adenocarcinoma and …
Mechanistic Insights Into The Reaction Of Chlorination Of Tryptophan Catalyzed By Tryptophan 7-Halogenase., Tatyana Karabencheva-Christova, Juan Torras, Adrian J Mulholland, Alessio Lodola, Christo Christov
Mechanistic Insights Into The Reaction Of Chlorination Of Tryptophan Catalyzed By Tryptophan 7-Halogenase., Tatyana Karabencheva-Christova, Juan Torras, Adrian J Mulholland, Alessio Lodola, Christo Christov
Michigan Tech Publications
Tryptophan 7-halogenase catalyzes chlorination of free tryptophan to 7-chlorotryptophan, which is the first step in the antibiotic pyrrolnitrin biosynthesis. Many biologically and pharmaceutically active natural products contain chlorine and thus, an understanding of the mechanism of its introduction into organic molecules is important. Whilst enzyme-catalyzed chlorination is accomplished with ease, it remains a difficult task for the chemists. Therefore, utilizing enzymes in the synthesis of chlorinated organic compounds is important, and providing atomistic mechanistic insights about the reaction mechanism of tryptophan 7-halogenase is vital and timely. In this work, we examined a mechanism for the reaction of tryptophan chlorination, performed …
Green Chemistry: Progress And Barriers, Sarah A. Green
Green Chemistry: Progress And Barriers, Sarah A. Green
Michigan Tech Publications
Green chemistry can advance both the health of the environment and the primary objectives of the chemical enterprise: to understand the behavior of chemical substances and to use that knowledge to make useful substances. We expect chemical research and manufacturing to be done in a manner that preserves the health and safety of workers; green chemistry extends that expectation to encompass the health and safety of the planet. While green chemistry may currently be treated as an independent branch of research, it should, like safety, eventually become integral to all chemistry activities. While enormous progress has been made in shifting …
Extracellular Expression Of Alkaline Phytase In Pichia Pastoris: Influence Of Signal Peptides, Promoters And Growth Medium, Mimi Yang, Sasha Teymorian, Philip Olivares, Pushpalatha P.N. Murthy
Extracellular Expression Of Alkaline Phytase In Pichia Pastoris: Influence Of Signal Peptides, Promoters And Growth Medium, Mimi Yang, Sasha Teymorian, Philip Olivares, Pushpalatha P.N. Murthy
Michigan Tech Publications
Alkaline phytase isolated from pollen grains of Lilium longiflorum (LlALP) possesses unique catalytic and thermal stability properties that suggest it has the potential to be used as a feed supplement. However, substantial amounts of active enzymes are needed for animal feed studies and endogenous levels of LlALP in lily pollen are too low to provide the required amounts. Active rLlALP2 (coded by LlAlp2, one of two isoforms of alkaline phytase cDNA identified in lily pollen) has been successfully expressed in intracellular compartments of Pichia pastoris, however enzyme yields have been modest (25-30 mg/L) and purification of the enzyme has been …
Atmospheric Peroxyacetyl Nitrate (Pan): A Global Budget And Source Attribution, E. V. Fischer, D. J. Jacob, R. M. Yantosca, M. P. Sulprizio, D. B. Millet, J. Mao, F. Paulot, H. B. Singh, A. Roiger, L. Ries, R. W. Talbot, K. Dzepina, S. Pandey Deolal
Atmospheric Peroxyacetyl Nitrate (Pan): A Global Budget And Source Attribution, E. V. Fischer, D. J. Jacob, R. M. Yantosca, M. P. Sulprizio, D. B. Millet, J. Mao, F. Paulot, H. B. Singh, A. Roiger, L. Ries, R. W. Talbot, K. Dzepina, S. Pandey Deolal
Michigan Tech Publications
Peroxyacetyl nitrate (PAN) formed in the atmospheric oxidation of non-methane volatile organic compounds (NMVOCs) is the principal tropospheric reservoir for nitrogen oxide radicals (NOx =NO+NO2). PAN enables the transport and release of NOx to the remote troposphere with major implications for the global distributions of ozone and OH, the main tropospheric oxidants. Simulation of PAN is a challenge for global models because of the dependence of PAN on vertical transport as well as complex and uncertain NMVOC sources and chemistry. Here we use an improved representation of NMVOCs in a global 3-D chemical transport model (GEOS-Chem) and show that it …
A Semi-Lagrangian View Of Ozone Production Tendency In North American Outflow In The Summers Of 2009 And 2010, B. Zhang, R. C. Owen, J A Perlinger, A. Kumar, S. Wu, M. Val Martin, L. Kramer, D. Helmig, R. E. Honrath
A Semi-Lagrangian View Of Ozone Production Tendency In North American Outflow In The Summers Of 2009 And 2010, B. Zhang, R. C. Owen, J A Perlinger, A. Kumar, S. Wu, M. Val Martin, L. Kramer, D. Helmig, R. E. Honrath
Michigan Tech Publications
The Pico Mountain Observatory, located at 2225 m a.s.l. in the Azores Islands, was established in 2001 to observe long-range transport from North America to the central North Atlantic. In previous research conducted at the observatory, ozone enhancement (> 55 ppbv) in North American outflows was observed, and efficient ozone production in these outflows was postulated. This study is focused on determining the causes for high d[O3] / d[CO] values (~1 ppbv ppbv−1) observed in the summers of 2009 and 2010. The folded retroplume technique, developed by Owen and Honrath (2009), was applied to combine upwind FLEXPART transport …