Chemistry Commons^™

Chiral Discrimination In Cyclodextrin Complexes Of Amino Acid Derivatives: Β-Cyclodextrin/N-Acetyl-L-Phenylalanine And N-Acetyl-D Phenylalanine Complexes, Jennifer M. Alexander, Joanna L. Clark, Tom J. Brett, John J. Stezowski

John J. Stezowski Publications

In a systematic study of molecular recognition of amino acid derivatives in solid-state β-cyclodextrin (β-CD) complexes, we have determined crystal structures for complexes of β-cyclodextrin/N -acetyl-L-phenylalanine at 298 and 20 K and for N-acetyl-D-phenylalanine at 298 K. The crystal structures for the N-acetyl-L-phenylalanine complex present disordered inclusion complexes for which the distribution of guest molecules at room temperature is not resolvable; however, they can be located with considerable confidence at low temperature. In contrast, the complex with N-acetyl-D-phenylalanine is well ordered at room temperature. The latter complex presents an example of a complex in this series …