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Synthesis And Characterization Of Novel Derivatives Of 1, 3, 4- 0xadiazole And Isoniazid, Ranem Mohammad Kaddoura

Chemistry Theses

This thesis describes the synthesis of novel derivatives of isoniazid and 1, 3, 4- oxadiazole piperazines and biological activities evaluation. The synthesis of the isoniazid derivatives (36a-Ɩ) was achieved by nucleophilic substitution of chloroacetylated isoniazid 34 with substituted piperazines (35a-Ɩ) produced isoniazidpiperazines (36a-Ɩ). On the other hand, cyclodehydration of chloroacetylated isoniazid 34 with POCl3 give the corresponding 1, 3, 4-oxadiazole 37 which upon treatment with substituted piperazines (35a-m) gave 1, 3, 4-oxadiazole-piperazines (38a-m). All newly synthesized compounds were purified and characterized using spectroscopic techniques including 1H-NMR, 13C-NMR, IR spectrometry and mass spectrometry.

The biological activity of the synthesized compounds has …