Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Physical Chemistry (10)
- Analytical Chemistry (5)
- Environmental Chemistry (5)
- Life Sciences (5)
- Organic Chemistry (5)
-
- Other Chemistry (5)
- Biochemistry (4)
- Biochemistry, Biophysics, and Structural Biology (4)
- Engineering (4)
- Materials Chemistry (4)
- Medicinal-Pharmaceutical Chemistry (4)
- Medicine and Health Sciences (4)
- Medical Sciences (3)
- Biochemical Phenomena, Metabolism, and Nutrition (2)
- Chemical Engineering (2)
- Chemical and Pharmacologic Phenomena (2)
- Environmental Sciences (2)
- Inorganic Chemistry (2)
- Medical Biochemistry (2)
- Atomic, Molecular and Optical Physics (1)
- Catalysis and Reaction Engineering (1)
- Civil and Environmental Engineering (1)
- Environmental Engineering (1)
- Materials Science and Engineering (1)
- Medical Toxicology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physics (1)
- Institution
- Keyword
-
- Animals (2)
- Brain (2)
- Chemistry (2)
- Conjugate addition (2)
- Dienophile (2)
-
- Enoate (2)
- Ethyl propiolate (2)
- Humans (2)
- Nanostructures (2)
- Nitric Oxide Synthase Type II (2)
- One-pot reactions (2)
- Oxidative Stress (2)
- Protein Carbonylation (2)
- Rats (2)
- Sulfide oxidation (2)
- Thiol (2)
- Ynoate (2)
- AGENT (1)
- Acids/Bases (1)
- Adipogenesis; CHOP10; RNase L; insulin response (1)
- Adult (1)
- Aerosol Formation (1)
- Aged (1)
- Aldehydes (1)
- Alzheimer (1)
- Alzheimer Disease (1)
- Amyloid beta-Peptides (1)
- Analytical Chemistry (1)
- Antioxidants (1)
- Antioxidants—DNA oxidation—human sperm—L-carnitine—motility—viability (1)
Articles 31 - 60 of 64
Full-Text Articles in Chemistry
Maxwell's Equations, Part Vii, David W. Ball
Maxwell's Equations, Part Vii, David W. Ball
Chemistry Faculty Publications
This is the seventh (and perhaps last) installment of a series of columns on Maxwell’s equations of electrodynamics. In previous columns (available at Spectroscopy’s website, www.spectroscopyonline.com/The+Baseline+Column), we have covered history, the background of the first three equations, and the mathematics underlying them. Here we will present the fourth equation, and after reaching it we’ll see how light is described in terms of these four mathematical expressions.
Patent: Methods Of Treating Fgf21-Associated Disorders, Brian R. Boettcher, Shari L. Caplan, Douglas S. Daniels, Bernhard Hubert Geierstanger, Norio Hamamatsu, Stuart Licht, Andreas Loew, Stephen Craig Weldon
Patent: Methods Of Treating Fgf21-Associated Disorders, Brian R. Boettcher, Shari L. Caplan, Douglas S. Daniels, Bernhard Hubert Geierstanger, Norio Hamamatsu, Stuart Licht, Andreas Loew, Stephen Craig Weldon
Chemistry Faculty Publications
The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, includ ing metabolic conditions.
Human Sperm Dna Oxidation, Motility And Viability In The Presence Of L-Carnitine During In Vitro Incubation And Centrifugation, S. Banihani, R. Sharma, Mekki Bayachou, E. Sabanegh, A. Agarwal
Human Sperm Dna Oxidation, Motility And Viability In The Presence Of L-Carnitine During In Vitro Incubation And Centrifugation, S. Banihani, R. Sharma, Mekki Bayachou, E. Sabanegh, A. Agarwal
Chemistry Faculty Publications
In vitro incubation and centrifugation is known to decrease human sperm quality. In the human body, besides its antioxidant effects, l-carnitine (LC) facilitates the transport of activated fatty acids from the cytosol to the mitochondrial matrix. In this study, we investigated the effect of LC on human sperm motility, viability and DNA oxidation after incubation and centrifugation, following the sperm preparation protocols of assisted reproduction. Normozoospermic semen samples (n = 55) were analysed according to the World Health Organization (WHO) guidelines. LC concentrations that are not toxic to spermatozoa as determined by sperm motility and viability were standardised after 2 …
Tuning Photophysics And Nonlinear Absorption Of Bipyridyl Platinum(Ii) Bisstilbenylacetylide Complexes By Auxiliary Substituents, Zhongjing Li, Ekaterina Badaeva, Dapeng Zhou, Josiah Bjorgaard, Ksenija D. Glusac, Svetlana Killina, Wenfang Sun
Tuning Photophysics And Nonlinear Absorption Of Bipyridyl Platinum(Ii) Bisstilbenylacetylide Complexes By Auxiliary Substituents, Zhongjing Li, Ekaterina Badaeva, Dapeng Zhou, Josiah Bjorgaard, Ksenija D. Glusac, Svetlana Killina, Wenfang Sun
Chemistry Faculty Publications
The photophysics of six bipyridyl platinum(II) bisstilbenylacetylide complexes with different auxiliary substituents are reported. These photophysical properties have been investigated in detail by UV-vis, photoluminescence (both at room temperature and at 77 K) and transient absorption (nanosecond and femtosecond) spectroscopies, as well as by linear response time-dependent density functional theory (TD-DFT) calculations. The photophysics of the complexes are found to be dominated by the singlet and triplet pi,pi* transitions localized at the stilbenylacetylide ligands with strong admixture of the metal-to-ligand (MLCT) and ligand-to-ligand (LLCT) charge-transfer characters. The interplay between the pi,pi* and MLCT/LLCT states depends on the electron-withdrawing or -donating …
Insufficient Radiofrequency Ablation Promotes Angiogenesis Of Residual Hepatocellular Carcinoma Via Hif-1Α/Vegfa, Jian Kong, Jinge Kong, Bing Pan, Shan Ke, Shuying Dong, Xiuli Li, Aimin Zhou, Lemin Zheng, Wen Bing Sun
Insufficient Radiofrequency Ablation Promotes Angiogenesis Of Residual Hepatocellular Carcinoma Via Hif-1Α/Vegfa, Jian Kong, Jinge Kong, Bing Pan, Shan Ke, Shuying Dong, Xiuli Li, Aimin Zhou, Lemin Zheng, Wen Bing Sun
Chemistry Faculty Publications
Background: The mechanism of rapid growth of the residual tumor after radiofrequency (RF) ablation is poorly understood. In this study, we investigated the effect of hyperthermia on HepG2 cells and generated a subline with enhanced viability and dys-regulated angiogenesis in vivo, which was used as a model to further determine the molecular mechanism of the rapid growth of residual HCC after RF ablation. Methodology/Principal Findings: Heat treatment was used to establish sublines of HepG2 cells. A subline (HepG2 k) with a relatively higher viability and significant heat tolerance was selected. The cellular protein levels of VEGFA, HIF-1α and p-Akt, VEGFA …
Introducing Nob-Nobs: Nitrogen-Oxygen-Boron Cycles With Potential High-Energy Properties, Aloysus K. Lawong, David W. Ball
Introducing Nob-Nobs: Nitrogen-Oxygen-Boron Cycles With Potential High-Energy Properties, Aloysus K. Lawong, David W. Ball
Chemistry Faculty Publications
As a follow-up on a study of a family of boron-oxygen-nitrogen compounds composed of two datively bonded B–O–N backbones, we investigate a similar series of compounds that have similar fragments but are covalently bonded. B3LYP/6-31G(d,p) quantum mechanical calculations have been performed to determine the minimum-energy geometries, vibrational frequencies, and thermochemical properties of the parent compound and a series of nitro-substituted derivatives. Our results indicate that some of the derivatives have at least appropriate thermodynamics for possible high-energy materials, in some cases being favorable over similar dimeric compounds with coordinate covalent B–N bonds
Photoisomerization And Relaxation Dynamics Of A Structurally Modified Biomimetic Photoswitch, Adam D. Dunkelberger, Ryan D. Kieda, Jae Yoon Shin, Riccardo Rossi Paccani, Stefania Fusi, Massimo Olivucci, F. Fleming Crim
Photoisomerization And Relaxation Dynamics Of A Structurally Modified Biomimetic Photoswitch, Adam D. Dunkelberger, Ryan D. Kieda, Jae Yoon Shin, Riccardo Rossi Paccani, Stefania Fusi, Massimo Olivucci, F. Fleming Crim
Chemistry Faculty Publications
Recent experimental and theoretical studies on N-alkylated indanylidene pyrroline Schiff bases (NAIP) show that these compounds exhibit biomimetic photoisomerization analogous to that in the chromophore of rhodopsin. The NAIP compounds studied previously isomerize rapidly and often evolve coherently on the ground-electronic surface after reaction. We present the results of transient electronic absorption spectroscopy on dMe-OMe-NAIP, a newly synthesized NAIP analogue that differs from other NAIP compounds in the substituents on its pyrrolinium ring. Following excitation with 400 nm light, dMe-OMe-NAIP relaxes from the electronic-excited state in less than 500 fs, which is slower than in other analogues, and does not …
Bon-Bons: Cyclic Molecules With A Boron-Oxygen-Nitrogen Backbone. Computational Studies Of Their Thermodynamic Properties, Aloysus K. Lawong, David W. Ball
Bon-Bons: Cyclic Molecules With A Boron-Oxygen-Nitrogen Backbone. Computational Studies Of Their Thermodynamic Properties, Aloysus K. Lawong, David W. Ball
Chemistry Faculty Publications
Although they were first reported in 1963, molecules with a boron-oxygen-nitrogen dimeric backbone do not seem to have been investigated seriously in terms of thermodynamic properties. Here we report on the calculated structures and properties, including thermodynamics, of several so-called “BON-BON” molecules. With the popularity of nitrogen-containing substituents on new high-energy materials, nitro-substituted BON-BONs were a focus of our investigation. A total of 42 BON-BON molecules were evaluated, and thermochemical analysis shows a decrease in the specific enthalpy of combustion or decomposition with increasing NO2 content, consistent with other systems.
Oxidative Stress In Hpv-Driven Viral Carcinogenesis: Redox Proteomics Analysis Of Hpv-16 Dysplastic And Neoplastic Tissues, Federico De Marco, Elona Bucaj, Cesira Foppoli, Ada Fiorini, Carla Blarzino, Kozeta Filipi, Alessandra Giorgi, Maria Eugenia Schininà, Fabio Di Domenico, Raffaella Coccia, D. Allan Butterfield, Marzia Perluigi
Oxidative Stress In Hpv-Driven Viral Carcinogenesis: Redox Proteomics Analysis Of Hpv-16 Dysplastic And Neoplastic Tissues, Federico De Marco, Elona Bucaj, Cesira Foppoli, Ada Fiorini, Carla Blarzino, Kozeta Filipi, Alessandra Giorgi, Maria Eugenia Schininà, Fabio Di Domenico, Raffaella Coccia, D. Allan Butterfield, Marzia Perluigi
Chemistry Faculty Publications
Genital infection by high risk Human Papillomavirus (HR-HPV), although recognized as the main etio-pathogenetic factor of cervical cancer, is not per se sufficient to induce tumour development. Oxidative stress (OS) represents an interesting and under-explored candidate as a promoting factor in HPV-initiated carcinogenesis. To gain insight into the role of OS in cervical cancer, HPV-16 positive tissues were collected from patients with invasive squamous cervical carcinoma, from patients with High Grade dysplastic HPV lesions and from patients with no clinical evidence of HPV lesions. After virological characterization, modulation of proteins involved in the redox status regulation was investigated. ERp57 and …
Probe Functionalization With A Rhop-3 Antibody: Toward A Rhop-3 Antigen Immunosensor For Detection Of Malaria, Salaam Saleh, Susan Moreno Molek, Perera N. Indika, Alan Riga, Tobili Sam Yellowe, Mekki Bayachou
Probe Functionalization With A Rhop-3 Antibody: Toward A Rhop-3 Antigen Immunosensor For Detection Of Malaria, Salaam Saleh, Susan Moreno Molek, Perera N. Indika, Alan Riga, Tobili Sam Yellowe, Mekki Bayachou
Chemistry Faculty Publications
The antibody specific for the malaria protein, Rhop-3, and FL-Rhop-3, were immobilized on the surface of a gold electrode modified with cysteamine. Colloidal gold was used to enhance the detection signal for Rhop-3 antigens. The Rhop-3 antibody was also immobilized on gold electrodes preactivated with dithiobis(succinimidyl proprionate) (DSP). Immobilization was performed at room temperature and at 37 °C. Cyclic voltammetry (CV) was used to monitor the interaction between the immobilized antibody and its cognate antigen in solution, using ferricyanide, K3Fe(CN)6, as reporting electroactive probe. Tests indicate recognition of Rhop-3 protein by the immobilized antibody. Antigen recognition was enhanced by incubation …
Photochemistry Of Monochloro Complexes Of Copper(Ii) In Methanol Probed By Ultrafast Transient Absorption Spectroscopy, Andrey S. Mereshchenko, Suman K. Pal, Kanykey E. Karabaeva, Patrick Z. El-Khoury, Alexander N. Tarnovsky
Photochemistry Of Monochloro Complexes Of Copper(Ii) In Methanol Probed By Ultrafast Transient Absorption Spectroscopy, Andrey S. Mereshchenko, Suman K. Pal, Kanykey E. Karabaeva, Patrick Z. El-Khoury, Alexander N. Tarnovsky
Chemistry Faculty Publications
Ultrafast transient absorption spectra in the deep to near UV range (212-384 nm) were measured for the [Cu-II(MeOH)(5)Cl](+) complexes in methanol following 255-nm excitation of the complex into the ligand-to-metal charge-transfer excited state. The electronically excited complex undergoes sub-200 fs radiationless decay, predominantly via back electron transfer, to the hot electronic ground state followed by fast vibrational relaxation on a 0.4-4 Ps time scale. A minor photochemical channel is Cu-Cl bond dissociation, leading to the reduction of copper(H) to copper(I) and the formation of MeOH center dot Cl charge-transfer complexes. The depletion of ground-state [Cu-II(MeOH)(5)Cl](+) perturbs the equilibrium between several …
Comprehensive Survey And Geometric Classification Of Base Triples In Rna Structures, Neocles B. Leontis, Amal S. Abu Almakarem, Anton I. Petrov, Jesse Stombaugh, Craig L. Zirbel
Comprehensive Survey And Geometric Classification Of Base Triples In Rna Structures, Neocles B. Leontis, Amal S. Abu Almakarem, Anton I. Petrov, Jesse Stombaugh, Craig L. Zirbel
Chemistry Faculty Publications
Base triples are recurrent clusters of three RNA nucleobases interacting edge-to-edge by hydrogen bonding. We find that the central base in almost all triples forms base pairs with the other two bases of the triple, providing a natural way to geometrically classify base triples. Given 12 geometric base pair families defined by the Leontis-Westhof nomenclature, combinatoric enumeration predicts 108 potential geometric base triple families. We searched representative atomic-resolution RNA 3D structures and found instances of 68 of the 108 predicted base triple families. Model building suggests that some of the remaining 40 families may be unlikely to form for steric …
Manipulating Protein Conformations By Single-Molecule Afm-Fret Nanoscopy, Yufan He, Maolin Lu, Jin Cao, H. Peter Lu
Manipulating Protein Conformations By Single-Molecule Afm-Fret Nanoscopy, Yufan He, Maolin Lu, Jin Cao, H. Peter Lu
Chemistry Faculty Publications
Combining atomic force microscopy and fluorescence resonance energy transfer spectroscopy (AFM-FRET), we have developed a single-molecule AFM-FRET nanoscopy approach capable of effectively pinpointing and mechanically manipulating a targeted dye-labeled single protein in a large sampling area and simultaneously monitoring the conformational changes of the targeted protein by recording single-molecule FRET time trajectories. We have further demonstrated an application of using this nanoscopy on manipulation of single-molecule protein conformation and simultaneous single-molecule FRET measurement of a Cy3-Cy5-labeled kinase enzyme, HPPK (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase). By analyzing time-resolved FRET trajectories and correlated AFM force pulling curves of the targeted single-molecule enzyme, we are able …
Toward A Stable Alpha-Cycloalkyl Amino Acid With A Photoswitchable Cationic Side Chain, Riccardo Rossi Paccani, Donato Donati, Stefania Fusi, Loredana Latterini, Grazia Farina, Vinicio Zanirato, Massimo Olivucci
Toward A Stable Alpha-Cycloalkyl Amino Acid With A Photoswitchable Cationic Side Chain, Riccardo Rossi Paccani, Donato Donati, Stefania Fusi, Loredana Latterini, Grazia Farina, Vinicio Zanirato, Massimo Olivucci
Chemistry Faculty Publications
The N-alkylated indanylidenepyrroline (NAIP) Schiff base 3 is an unnatural a-amino acid precursor potentially useful for the preparation of semisynthetic peptides and proteins incorporating charged side chains whose structure can be modulated via Z/E photoisomerization. Here we report that the heteroallylic protons of 3 led to partial loss of ethanol accompanied by formation of the novel heterocyclic system 4 during attempted deprotection. We also show that the same protons catalyze the thermal isomerization of 3, making the light-driven conformational control concept ineffective for times longer than a few hours. These problems are not present in the previously unreported compound 5 …
One-Pot Synthesis In Polyamines For Preparation Of Water-Soluble Magnetite Nanoparticles With Amine Surface Reactivity, Haiou Qu, Hui Ma, Aurélien Riviere, Weilie Zhou, Charles J. O'Connor
One-Pot Synthesis In Polyamines For Preparation Of Water-Soluble Magnetite Nanoparticles With Amine Surface Reactivity, Haiou Qu, Hui Ma, Aurélien Riviere, Weilie Zhou, Charles J. O'Connor
Chemistry Faculty Publications
Magnetite nanoparticles with hydrophilic surface coating are prepared in polyamine solvents. The resulting products are highly stable in polar solvent. The surface amine groups are available for secondary reactions.
Water Diffusion In And Out Of The Β-Barrel Of Gfp And The Fast Maturing Fluorescent Protein, Turbogfp, Marc Zimmer, Binsen Li, Ramza Shahid, Paola Peshkepija
Water Diffusion In And Out Of The Β-Barrel Of Gfp And The Fast Maturing Fluorescent Protein, Turbogfp, Marc Zimmer, Binsen Li, Ramza Shahid, Paola Peshkepija
Chemistry Faculty Publications
The chromophore of fluorescent proteins is formed by an internal cyclization of the tripeptide 65SYG67 fragment and a subsequent oxidation. The oxidation is slow – the kinetics of this step is presumably improved in fast maturing GFPs. Water molecules can aid in the chromophore formation. We have used 50ns molecular dynamics simulations of the mature and immature forms of avGFP and TurboGFP to examine the diffusion of water molecules in-and-out of the protein β-barrel. Most crystal structures of GFPs have well-structured waters within hydrogen-bonding distance of Glu222 and Arg96. It has been proposed that they have an important role in …
Oxidative Stress And Down Syndrome: A Route Toward Alzheimer-Like Dementia, Marzia Perluigi, D. Allan Butterfield
Oxidative Stress And Down Syndrome: A Route Toward Alzheimer-Like Dementia, Marzia Perluigi, D. Allan Butterfield
Chemistry Faculty Publications
Down syndrome (DS) is one of the most frequent genetic abnormalities characterized by multiple pathological phenotypes. Indeed, currently life expectancy and quality of life for DS patients have improved, although with increasing age pathological dysfunctions are exacerbated and intellectual disability may lead to the development of Alzheimer's type dementia (AD). The neuropathology of DS is complex and includes the development of AD by middle age, altered free radical metabolism, and impaired mitochondrial function, both of which contribute to neuronal degeneration. Understanding the molecular basis that drives the development of AD is an intense field of research. Our laboratories are interested …
Development Of A ‘Clickable’ Non-Natural Nucleotide To Visualize The Replication Of Non-Instructional Dna Lesions, Edward A. Motea, Irene Lee, Anthony J. Berdis
Development Of A ‘Clickable’ Non-Natural Nucleotide To Visualize The Replication Of Non-Instructional Dna Lesions, Edward A. Motea, Irene Lee, Anthony J. Berdis
Chemistry Faculty Publications
The misreplication of damaged DNA is an important biological process that produces numerous adverse effects on human health. This report describes the synthesis and characterization of a non-natural nucleotide, designated 3-ethynyl-5-nitroindolyl-2′-deoxyriboside triphosphate (3-Eth-5-NITP), as a novel chemical reagent that can probe and quantify the misreplication of damaged DNA. We demonstrate that this non-natural nucleotide is efficiently inserted opposite an abasic site, a commonly formed and potentially mutagenic non-instructional DNA lesion. The strategic placement of the ethynyl moiety allows the incorporated nucleoside triphosphate to be selectively tagged with an azide-containing fluorophore using ‘click’ chemistry. This reaction provides a facile way to …
From Cox-2 Inhibitor Nimesulide To Potent Anti-Cancer Agent: Synthesis, In Vitro, In Vivo And Pharmacokinetic Evaluation, Bo Zhong, Xiaohan Cai, Snigdha Chennamaneni, Xin Yi, Lili Liu, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, Bin Su
From Cox-2 Inhibitor Nimesulide To Potent Anti-Cancer Agent: Synthesis, In Vitro, In Vivo And Pharmacokinetic Evaluation, Bo Zhong, Xiaohan Cai, Snigdha Chennamaneni, Xin Yi, Lili Liu, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, Bin Su
Chemistry Faculty Publications
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. In the presented study, a series of new nimesulide analogs were synthesized based on the structure–function analysis generated previously. Some of them displayed very potent anti-cancer activity with IC50s around 100 nM–200 nM to inhibit SKBR-3 breast cancer cell growth. CSUOH0901 (NSC751382) from the compound library also inhibits the growth of the 60 cancer cell lines used at National Cancer Institute Developmental therapeutics Program (NCIDTP) with IC50s around 100 nM–500 nM. …
Removal Of Uracil By Uracil Dna Glycosylase Limits Pemetrexed Cytotoxicity: Overriding The Limit With Methoxyamine To Inhibit Base Excision Repair, A. D. Bulgar, L. D. Weeks, Y. Miao, S. Yang, Yan Xu, C. Guo, S. Markowitz, N. Oleinick, S. L. Gerson, Lili Liu
Removal Of Uracil By Uracil Dna Glycosylase Limits Pemetrexed Cytotoxicity: Overriding The Limit With Methoxyamine To Inhibit Base Excision Repair, A. D. Bulgar, L. D. Weeks, Y. Miao, S. Yang, Yan Xu, C. Guo, S. Markowitz, N. Oleinick, S. L. Gerson, Lili Liu
Chemistry Faculty Publications
Uracil DNA glycosylase (UDG) specifically removes uracil bases from DNA, and its repair activity determines the sensitivity of the cell to anticancer agents that are capable of introducing uracil into DNA. In the present study, the participation of UDG in the response to pemetrexed-induced incorporation of uracil into DNA was studied using isogenic human tumor cell lines with or without UDG (UDG+/+/UDG−/−). UDG−/− cells were very sensitive to pemetrexed. Cell killing by pemetrexed was associated with genomic uracil accumulation, stalled DNA replication, and catastrophic DNA strand breaks. By contrast, UDG+/+ cells were >10 times more resistant to pemetrexed due to …
Making Bread From Air: The World's Most Important Chemical Synthesis, Kurt W. Kolasinski
Making Bread From Air: The World's Most Important Chemical Synthesis, Kurt W. Kolasinski
Chemistry Faculty Publications
No abstract provided.
Magnetoelectric Effect In Ain/Cofe Bi-Layer Thin Film Composites, S Narendra Babu, Seong-Gi Min, Amin Yourdkhani, Gabriel Caruntu, Leszek M. Malkinski
Magnetoelectric Effect In Ain/Cofe Bi-Layer Thin Film Composites, S Narendra Babu, Seong-Gi Min, Amin Yourdkhani, Gabriel Caruntu, Leszek M. Malkinski
Chemistry Faculty Publications
The present work is aimed at fabricating bi-layer aluminum nitride (AlN)/cobalt iron (CoFe) magnetoelectric (ME) thin films using reactive rf/dc magnetron sputtering. A systematic study on structural, morphological, piezoelectric, magnetic and magnetoelectric properties is undertaken. Except for AlN and CoFe, no other phases were detected with the layer thicknesses measured at160 and 130 nm, respectively. The rms roughness measured was around 2.096 nm for AlN and 1.806 nm for CoFe. The bi-layer thin film exhibited both good piezoelectricity and ferromagnetism, as well as ME effect. A 52% change observed in the piezoelectric signal, measured using magnetic field assisted piezoresponse force …
Dynamics And Collective State Of Ordered Magnetic Nanoparticles In Mesoporous Systems, Jose M. Vargas, Abhishek Srivastava, Ezra Garza, Gabriel Caruntu, Amin Yourdkhani, Leonard Spinu
Dynamics And Collective State Of Ordered Magnetic Nanoparticles In Mesoporous Systems, Jose M. Vargas, Abhishek Srivastava, Ezra Garza, Gabriel Caruntu, Amin Yourdkhani, Leonard Spinu
Chemistry Faculty Publications
In this paper we present a study of superparamagnetic and superspin glass states of magnetic nanoparticles confined in mesoporous templates. Characterization utilizes dynamic magnetization techniques, ac susceptibility, and ferromagnetic resonance, in addition to dc magnetization curves. In order to differentiate between the intrinsic and collective properties, we considered three magnetic nanoparticles systems with comparable size, shape, and crystallinity but with different intrinsic magnetocrystalline anisotropy. Further, confinement effects were studied by considering three different geometries of nanoparticles. The effect of the geometrical confinement and intrinsic anisotropy of the nanoparticles are discussed based on known theoretical predictions.
Synthesis And Piezoelectric Response Of Cubic And Spherical Linbo3 Nanocrystals, Debasish Mohanty, Girija S. Chaubey, Amin Yourdkhani, Shiva Adireddy, Gabriel Caruntu, John B. Wiley
Synthesis And Piezoelectric Response Of Cubic And Spherical Linbo3 Nanocrystals, Debasish Mohanty, Girija S. Chaubey, Amin Yourdkhani, Shiva Adireddy, Gabriel Caruntu, John B. Wiley
Chemistry Faculty Publications
Methods have been developed for the shape-selective synthesis of ferroelectric LiNbO3 nanoparticles. Decomposition of the single-source precursor, LiNb(O-Et)6, in the absence of surfactants, can reproducibly lead to either cube- or sphere-like nanoparticles. X-Ray diffraction shows that the LiNbO3 nanoparticles are rhombohedral (R3c). Sample properties were examined by piezoresponse force microscopy (PFM) and Raman where both sets of nanoparticles exhibit ferroelectricity. The longitudinal piezoelectric coefficients, d33, varied with shape where the largest value was exhibited in the nanocubes (17 pm V21 for the cubes versus 12 pm V21 for spheres).
Dynamics And Collective State Of Ordered Magnetic Nanoparticles In Mesoporous Systems, Jose M. Vargas, Abhishek Srivastava, Ezra Garza, Amin Yourdkhani, Gabriel Caruntu, Leonard Spinu
Dynamics And Collective State Of Ordered Magnetic Nanoparticles In Mesoporous Systems, Jose M. Vargas, Abhishek Srivastava, Ezra Garza, Amin Yourdkhani, Gabriel Caruntu, Leonard Spinu
Chemistry Faculty Publications
In this paper we present a study of superparamagnetic and superspin glass states of magnetic nanoparticles confined in mesoporous templates. Characterization utilizes dynamic magnetization techniques, ac susceptibility, and ferromagnetic resonance, in addition to dc magnetization curves. In order to differentiate between the intrinsic and collective properties, we considered three magnetic nanoparticles systems with comparable size, shape, and crystallinity but with different intrinsic magnetocrystalline anisotropy. Further, confinement effects were studied by considering three different geometries of nanoparticles. The effect of the geometrical confinement and intrinsic anisotropy of the nanoparticles are discussed based on known theoretical predictions.
Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill
Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill
Chemistry Faculty Publications
Neospora caninum is considered to be the main cause of bovine abortion in Europe and the USA, leading to considerable financial impact. Losses are caused directly by abortions or indirectly through breeding of calves with impaired viability. Due to the lack of effective chemotherapy against bovine neosporosis, there is a need to develop new anti-protozoal compounds, which would either eliminate the parasite or avoid its transmission. In order to identify compounds of interest, the in vitro activities of 41 di-cationic pentamidine derivatives were studied employing a transgenic N. caninum clone expressing beta-galactosidase as a reporter gene. The arylimidamide DB745, previously …
Insight Into The Modulation Of Shaw2 Kv Channels By General Anesthetics: Structural And Functional Studies Of S4-S5 Linker And S6 C-Terminal Peptides In Micelles By Nmr, Jin Zhang, Xiaoguang Qu, Manuel Covarrubias, Markus W. Germann
Insight Into The Modulation Of Shaw2 Kv Channels By General Anesthetics: Structural And Functional Studies Of S4-S5 Linker And S6 C-Terminal Peptides In Micelles By Nmr, Jin Zhang, Xiaoguang Qu, Manuel Covarrubias, Markus W. Germann
Chemistry Faculty Publications
The modulation of the Drosophila Shaw2 Kv channel by 1-alkanols and inhaled anesthetics is correlated with the involvement of the S4–S5 linker and C-terminus of S6, and consistent with stabilization of the channel's closed state. Structural analysis of peptides from S4–S5 (L45) and S6 (S6c), by nuclear magnetic resonance and circular dichroism spectroscopy supports that an α-helical conformation was adopted by L45, while S6c was only in an unstable/dynamic partially folded α-helix in dodecylphosphocholine micelles. Solvent accessibility and paramagnetic probing of L45 revealed that L45 lies parallel to the surface of micelles with charged and polar residues pointing towards the …
Synthesis And Flame Retardant Testing Of New Boronated And Phosphonated Aromatic Compounds, Vladimir Benin, Sravanthi Durganala, Alexander Morgan
Synthesis And Flame Retardant Testing Of New Boronated And Phosphonated Aromatic Compounds, Vladimir Benin, Sravanthi Durganala, Alexander Morgan
Chemistry Faculty Publications
The present report describes the preparation and use of some dimethyl terephthalate derivatives in transition metal-catalyzed coupling reactions to produce new reactive flame retardants. Dimethyl iodoterephthalate and dimethyl 2,5-diiodoterephthalate were successfully employed in the preparation of phosphonic and boronic esters and acids. The latter were tested for heat release with a microcombustion calorimeter (ASTM D7309) to determine the potential for heat release reduction of these flame retardant molecules. The results showed that the addition of boronic or phosphonic acids greatly lowered the heat release, due to a condensed phase (char formation) mechanism. Adding ester groups to the boronic acids or …
Nitric Oxide Synthase Encapsulation In Liposomes: A Potential Delivery Platform To (Nitric Oxide)-Deficient Targets, Reshani H. Perera, Pubudu M. Peiris, Serban F. Peteu, Mekki Bayachou
Nitric Oxide Synthase Encapsulation In Liposomes: A Potential Delivery Platform To (Nitric Oxide)-Deficient Targets, Reshani H. Perera, Pubudu M. Peiris, Serban F. Peteu, Mekki Bayachou
Chemistry Faculty Publications
Nitric oxide (NO) is a freely diffusible, gaseous free radical, associated with many physiological and pathological processes: such as neuronal signaling, immune response and inflammatory response. In mammalian organisms, NO is produced from L-arginine in an NADPH-dependent reaction catalyzed by a family of nitric oxide synthase (NOS) enzymes. Typically, large NO fluctuations in biological systems under/over a critical limit is associated with problems that range from transient dysfunctions to severe chronic disease states. In this regard, we explore the development of a potential delivery and release method of nitric oxide to NO-deficient sites using liposomes as vehicles. Liposomes have already …
Maxwell's Equations, Part V, David W. Ball
Maxwell's Equations, Part V, David W. Ball
Chemistry Faculty Publications
This is the fifth installment in a series devoted to explaining Maxwell’s equations, the four mathematical statements upon which the classical theory of electromagnetic fields – and light – is based. Previous installments can be found on Spectroscopy’s website (whose URL can be found throughout these issues). Maxwell’s equations are expressed in the language of vector calculus, so a significant part of some previous columns have been devoted to explaining vector calculus, not spectroscopy. For better or worse, that’s par for the course, and it’s my job to explain it well – I trust readers will let me know if …