Chemistry Commons^™

Nitric Oxide Synthase Encapsulation In Liposomes: A Potential Delivery Platform To (Nitric Oxide)-Deficient Targets, Reshani H. Perera, Pubudu M. Peiris, Serban F. Peteu, Mekki Bayachou

Chemistry Faculty Publications

Nitric oxide (NO) is a freely diffusible, gaseous free radical, associated with many physiological and pathological processes: such as neuronal signaling, immune response and inflammatory response. In mammalian organisms, NO is produced from L-arginine in an NADPH-dependent reaction catalyzed by a family of nitric oxide synthase (NOS) enzymes. Typically, large NO fluctuations in biological systems under/over a critical limit is associated with problems that range from transient dysfunctions to severe chronic disease states. In this regard, we explore the development of a potential delivery and release method of nitric oxide to NO-deficient sites using liposomes as vehicles. Liposomes have already …