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2022

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Full-Text Articles in Chemistry

Binding Interactions Between Mixed-Monlayer Functionalized Gold Nanoparticles (Aunps) And The Serum Protein Albumin, Jennifer Hanigan-Diebel Jan 2022

Binding Interactions Between Mixed-Monlayer Functionalized Gold Nanoparticles (Aunps) And The Serum Protein Albumin, Jennifer Hanigan-Diebel

All Master's Theses

This study investigated the protein adsorption interactions of bovine serum albumin (BSA) with three different functionalized 5 nm gold nanoparticles (AuNPs) in order to determine the binding affinity and total amount of protein adsorbed to each AuNP surface chemistry. AuNPs were synthesized using two different capping agents to display three different surface chemistries: a neutral ω-functionalized thiol ligand (mercapto-ethoxy-ethoxy-ethanol, MEEE), a thiol ligand that is negatively charged at pH 7.4 (mercaptohexanoic acid, MHA), and a mixture of the two ligands (mixed-ligand AuNPs). The interactions of this library of AuNPs with bovine serum albumin (BSA) were investigated using UV-visible absorbance spectroscopy, …

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Computer Aided Design: Targeting The Pac1r For Novel Therapeutics And Investigating Biologically Relevant Materials, Kyle Thomas Mckay Jan 2022

Computer Aided Design: Targeting The Pac1r For Novel Therapeutics And Investigating Biologically Relevant Materials, Kyle Thomas Mckay

Graduate College Dissertations and Theses

Computer aided drug design, a collection of computational methodologies including structure and ligand based drug design, has emerged as an efficient and accurate way to expedite the drug discovery process. Structure based drug design — methods which rely on the 3-dimensional structural information of biological targets — are of particular interest to chemists. Unfortunately, structural information can be difficult to obtain, and this can limit the usefulness of these methodologies. New methodologies and workflows, which are less reliant on difficult to obtain structural information are needed to fill in the gaps and push the drug development process forward. The first …

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Analysis Of Blue Fountain Pen Ink By Uv-Vis Spectroscopy, Atr-Ftir Spectroscopy, And Thin Layer Chromatography Enhanced With Rgb Spot Evaluation To Construct A Database For Comparison And Identification., Elliot D. Quinteros Jan 2022

Analysis Of Blue Fountain Pen Ink By Uv-Vis Spectroscopy, Atr-Ftir Spectroscopy, And Thin Layer Chromatography Enhanced With Rgb Spot Evaluation To Construct A Database For Comparison And Identification., Elliot D. Quinteros

Dissertations and Theses

Pen ink can be a crucial piece of physical evidence in the area of Forensic Science. For example, evidence such as notes, letters, printed documents, checks, currency, ransom notes, and books may contain ink. Analysis of ink is typically done for identification or differentiation purposes. To improve existing methods, it was proposed to create a database with many samples and experimental information. The methods used and evaluated were thin-layer chromatography (TLC) enhanced with RGB spot evaluation, UV-Vis spectroscopy, and ATR-FTIR spectroscopy. All three methods were used to analyze 89 fountain pen ink samples. All three methods were able to discriminate …

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Analysis Of Forensically Relevant Evidence Using Electrochemistry, Spectroscopy, And Mass Spectrometry Tools, Colby Edward Ott Jan 2022

Analysis Of Forensically Relevant Evidence Using Electrochemistry, Spectroscopy, And Mass Spectrometry Tools, Colby Edward Ott

Graduate Theses, Dissertations, and Problem Reports

Forensic science relies on the use of multiple techniques in the assessment of evidence to increase the accuracy and reliability of the results. However, with the rapidly changing drug landscape due to the introduction of novel psychoactive substances, many traditional screening methods are no longer sensitive or selective enough for use. Additionally, many screening methods such as chemical color tests are prone to false positive and negative results and are subjective. Therefore, the goal of this dissertation was to develop a novel analytical scheme that can provide a more efficient, rapid, and sensitive method that will facilitate adoption in the …

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Electrochemical Impedance Spectroscopy Analysis Of Corrosion Of Reinforcing Steel In Fly Ash Mortar By Means Of Transmission Line Modeling, Padraig Stack Jan 2022

Electrochemical Impedance Spectroscopy Analysis Of Corrosion Of Reinforcing Steel In Fly Ash Mortar By Means Of Transmission Line Modeling, Padraig Stack

Williams Honors College, Honors Research Projects

Electrochemical impedance spectroscopy (EIS) is an important non-destructive tool that allows for a deeper understanding of the electrochemical processes and mechanisms occurring in an electrochemical cell. Equivalent electrical circuits (EECs) are used to model the impedance data into electrical components, such as resistors and capacitors, on a circuit. Current potentiostat offers software packages that can analyze the frequency response, but the software only supports “simple” EEC that can be written as fixed electrical components in some combination of series and parallel. Park and Macdonald propose a transmission line model (TLM) that does not use lumped-element models, instead, the values of …

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