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Study Of Antioxidant Activity Of The Derivatives Of Quinoline-4-Carboxylic Acids By The Modification Of Isatin Via Pfitzinger Reaction, Sakti Hidayati Fikriya, Antonius Herry Cahyana
Study Of Antioxidant Activity Of The Derivatives Of Quinoline-4-Carboxylic Acids By The Modification Of Isatin Via Pfitzinger Reaction, Sakti Hidayati Fikriya, Antonius Herry Cahyana
Makara Journal of Science
In this study, a quinoline-4-carboxylic acid derivative was synthesized through Pfitzinger reaction. In this reaction, isatin is modified via its reaction with ketone and refluxed for 24 h to obtain quinoline-4-carboxylic acid. The presence of a carboxylic group was identified by Fourier Transform Infrared (FTIR) spectroscopy and ultraviolet–visible (UV-Vis) spectrophotometry. The results showed that the absorption peaks of C=O and O–H stretching’s were detected in the range of 1724–1708 and 3436–3242 cm−1, respectively. In the UV-vis spectrum, a shift in the absorption peak was observed toward a larger wavelength, which is referred as a bathochromic shift. The formation …