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A Physiologically-Based Pharmacokinetic Model For Vancomycin, Rebekah White
A Physiologically-Based Pharmacokinetic Model For Vancomycin, Rebekah White
Undergraduate Honors Theses
Vancomycin is an antibiotic used for the treatment of systemic infections. It is given
intravenously usually every twelve or twenty-four hours. This particular drug has a
medium level of boundedness, with approximately fty percent of the drug being free
and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)
model was used to better understand the absorption, distribution, and elimination of
the drug. Using optimal parameters, the model could be used in the future to test
how various factors, such as BMI or excretion levels, might aect the concentration
of the antibiotic.