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Full-Text Articles in Ordinary Differential Equations and Applied Dynamics

Relaxation And Linear Programs On A Hybrid Control Model, Héctor Jasso-Fuentes, Jose-Luis Menaldi Sep 2019

Relaxation And Linear Programs On A Hybrid Control Model, Héctor Jasso-Fuentes, Jose-Luis Menaldi

Mathematics Faculty Research Publications

Some optimality results for hybrid control problems are presented. The hybrid model under study consists of two subdynamics, one of a standard type governed by an ordinary differential equation, and the other of a special type having a discrete evolution. We focus on the case when the interaction between the subdynamics takes place only when the state of the system reaches a given fixed region of the state space. The controller is able to apply two controls, each applied to one of the two subdynamics, whereas the state follows a composite evolution, of continuous type and discrete type. By the …


Parameter Estimation And Optimal Design Techniques To Analyze A Mathematical Model In Wound Healing, Nigar Karimli Apr 2019

Parameter Estimation And Optimal Design Techniques To Analyze A Mathematical Model In Wound Healing, Nigar Karimli

Masters Theses & Specialist Projects

For this project, we use a modified version of a previously developed mathematical model, which describes the relationships among matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and extracellular matrix (ECM). Our ultimate goal is to quantify and understand differences in parameter estimates between patients in order to predict future responses and individualize treatment for each patient. By analyzing parameter confidence intervals and confidence and prediction intervals for the state variables, we develop a parameter space reduction algorithm that results in better future response predictions for each individual patient. Moreover, use of another subset selection method, namely Structured Covariance Analysis, that …