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Full-Text Articles in Ordinary Differential Equations and Applied Dynamics

Parameter Estimation And Optimal Design Techniques To Analyze A Mathematical Model In Wound Healing, Nigar Karimli Apr 2019

Parameter Estimation And Optimal Design Techniques To Analyze A Mathematical Model In Wound Healing, Nigar Karimli

Masters Theses & Specialist Projects

For this project, we use a modified version of a previously developed mathematical model, which describes the relationships among matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and extracellular matrix (ECM). Our ultimate goal is to quantify and understand differences in parameter estimates between patients in order to predict future responses and individualize treatment for each patient. By analyzing parameter confidence intervals and confidence and prediction intervals for the state variables, we develop a parameter space reduction algorithm that results in better future response predictions for each individual patient. Moreover, use of another subset selection method, namely Structured Covariance Analysis, that …


Analysis And Implementation Of Numerical Methods For Solving Ordinary Differential Equations, Muhammad Sohel Rana Oct 2017

Analysis And Implementation Of Numerical Methods For Solving Ordinary Differential Equations, Muhammad Sohel Rana

Masters Theses & Specialist Projects

Numerical methods to solve initial value problems of differential equations progressed quite a bit in the last century. We give a brief summary of how useful numerical methods are for ordinary differential equations of first and higher order. In this thesis both computational and theoretical discussion of the application of numerical methods on differential equations takes place. The thesis consists of an investigation of various categories of numerical methods for the solution of ordinary differential equations including the numerical solution of ordinary differential equations from a number of practical fields such as equations arising in population dynamics and astrophysics. It …


Green's Functions Of Discrete Fractional Calculus Boundary Value Problems And An Application Of Discrete Fractional Calculus To A Pharmacokinetic Model, Sutthirut Charoenphon May 2014

Green's Functions Of Discrete Fractional Calculus Boundary Value Problems And An Application Of Discrete Fractional Calculus To A Pharmacokinetic Model, Sutthirut Charoenphon

Masters Theses & Specialist Projects

Fractional calculus has been used as a research tool in the fields of pharmacology, biology, chemistry, and other areas [3]. The main purpose of this thesis is to calculate Green's functions of fractional difference equations, and to model problems in pharmacokinetics. We claim that the discrete fractional calculus yields the best prediction performance compared to the continuous fractional calculus in the application of a one-compartmental model of drug concentration. In Chapter 1, the Gamma function and its properties are discussed to establish a theoretical basis. Additionally, the basics of discrete fractional calculus are discussed using particular examples for further calculations. …


Minimizing Travel Time Through Multiple Media With Various Borders, Tonja Miick May 2013

Minimizing Travel Time Through Multiple Media With Various Borders, Tonja Miick

Masters Theses & Specialist Projects

This thesis consists of two main chapters along with an introduction and
conclusion. In the introduction, we address the inspiration for the thesis, which
originates in a common calculus problem wherein travel time is minimized across two media separated by a single, straight boundary line. We then discuss the correlation of this problem with physics via Snells Law. The first core chapter takes this idea and develops it to include the concept of two media with a circular border. To make the problem easier to discuss, we talk about it in terms of running and swimming speeds. We first address …