Ordinary Differential Equations and Applied Dynamics Commons^™

Bifurcation Of Limit Cycles In Smooth And Non-Smooth Dynamical Systems With Normal Form Computation, Yun Tian

Electronic Thesis and Dissertation Repository

This thesis contains two parts. In the first part, we investigate bifurcation of limit cycles around a singular point in planar cubic systems and quadratic switching systems. For planar cubic systems, we study cubic perturbations of a quadratic Hamiltonian system and obtain 10 small-amplitude limit cycles bifurcating from an elementary center, for which up to 5th-order Melnikov functions are used. Moreover, we prove the existence of 12 small-amplitude limit cycles around a singular point in a cubic system by computing focus values. For quadratic switching system, we develop a recursive algorithm for computing Lyapunov constants. With this efficient algorithm, we …

Understanding Recurrent Disease: A Dynamical Systems Approach, Wenjing Zhang

Electronic Thesis and Dissertation Repository

Recurrent disease, characterized by repeated alternations between acute relapse and long re- mission, can be a feature of both common diseases, like ear infections, and serious chronic diseases, such as HIV infection or multiple sclerosis. Due to their poorly understood etiology and the resultant challenge for medical treatment and patient management, recurrent diseases attract much attention in clinical research and biomathematics. Previous studies of recurrence by biomathematicians mainly focus on in-host models and generate recurrent patterns by in- corporating forcing functions or stochastic elements. In this study, we investigate deterministic in-host models through the qualitative analysis of dynamical systems, to …

Study Of Virus Dynamics By Mathematical Models, Xiulan Lai

Electronic Thesis and Dissertation Repository

This thesis studies virus dynamics within host by mathematical models, and topics discussed include viral release strategies, viral spreading mechanism, and interaction of virus with the immune system.

Firstly, we propose a delay differential equation model with distributed delay to investigate the evolutionary competition between budding and lytic viral release strategies. We find that when antibody is not established, the dynamics of competition depends on the respective basic reproduction numbers of the two viruses. If the basic reproductive ratio of budding virus is greater than that of lytic virus and one, budding virus can survive. When antibody is established for …