Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

2005

Statistical Theory

Articles 121 - 138 of 138

Full-Text Articles in Physical Sciences and Mathematics

Some Guidelines For Using Nonparametric Methods For Modeling Data From Response Surface Designs, Christine M. Anderson-Cook, Kathryn Prewitt May 2005

Some Guidelines For Using Nonparametric Methods For Modeling Data From Response Surface Designs, Christine M. Anderson-Cook, Kathryn Prewitt

Journal of Modern Applied Statistical Methods

Traditional response surface methodology focuses on modeling responses using parametric models with designs chosen to balance cost with adequate estimation of parameters and prediction in the design space. Using nonparametric smoothing to approximate the response surface offers both opportunities as well as problems. This article explores some conditions under which these methods can be appropriately used to increase the flexibility of surfaces modeled. The Box and Draper (1987) printing ink study is considered to illustrate the methods.

Go to article

On The Power Function Of Bayesian Tests With Application To Design Of Clinical Trials: The Fixed-Sample Case, Lyle Broemeling, Dongfeng Wu May 2005

On The Power Function Of Bayesian Tests With Application To Design Of Clinical Trials: The Fixed-Sample Case, Lyle Broemeling, Dongfeng Wu

Journal of Modern Applied Statistical Methods

Using a Bayesian approach to clinical trial design is becoming more common. For example, at the MD Anderson Cancer Center, Bayesian techniques are routinely employed in the design and analysis of Phase I and II trials. It is important that the operating characteristics of these procedures be determined as part of the process when establishing a stopping rule for a clinical trial. This study determines the power function for some common fixed-sample procedures in hypothesis testing, namely the one and two-sample tests involving the binomial and normal distributions. Also considered is a Bayesian test for multi-response (response and toxicity) in …

Go to article

Right-Tailed Testing Of Variance For Non-Normal Distributions, Michael C. Long, Ping Sa May 2005

Right-Tailed Testing Of Variance For Non-Normal Distributions, Michael C. Long, Ping Sa

Journal of Modern Applied Statistical Methods

A new test of variance for non-normal distribution with fewer restrictions than the current tests is proposed. Simulation study shows that the new test controls the Type I error rate well, and has power performance comparable to the competitors. In addition, it can be used without restrictions.

Go to article

Manifestation Of Differences In Item-Level Characteristics In Scale-Level Measurement Invariance Tests Of Multi-Group Confirmatory Factor Analyses, Bruno D. Zumbo, Kim H. Koh May 2005

Manifestation Of Differences In Item-Level Characteristics In Scale-Level Measurement Invariance Tests Of Multi-Group Confirmatory Factor Analyses, Bruno D. Zumbo, Kim H. Koh

Journal of Modern Applied Statistical Methods

If a researcher applies the conventional tests of scale-level measurement invariance through multi-group confirmatory factor analysis of a PC matrix and MLE to test hypotheses of strong and full measurement invariance when the researcher has a rating scale response format wherein the item characteristics are different for the two groups of respondents, do these scale-level analyses reflect (or ignore) differences in item threshold characteristics? Results of the current study demonstrate the inadequacy of judging the suitability of a measurement instrument across groups by only investigating the factor structure of the measure for the different groups with a PC matrix and …

Go to article

Multiple Imputation For Missing Ordinal Data, Ling Chen, Marian Toma-Drane, Robert F. Valois, J. Wanzer Drane May 2005

Multiple Imputation For Missing Ordinal Data, Ling Chen, Marian Toma-Drane, Robert F. Valois, J. Wanzer Drane

Journal of Modern Applied Statistical Methods

Simulations were used to compare complete case analysis of ordinal data with including multivariate normal imputations. MVN methods of imputation were not as good as using only complete cases. Bias and standard errors were measured against coefficients estimated from logistic regression and a standard data set.

Go to article

A Comparison Of Parametric And Coarsened Bayesian Interval Estimation In The Presence Of A Known Mean-Variance Relationship, Kent Koprowicz, Scott S. Emerson, Peter Hoff Apr 2005

A Comparison Of Parametric And Coarsened Bayesian Interval Estimation In The Presence Of A Known Mean-Variance Relationship, Kent Koprowicz, Scott S. Emerson, Peter Hoff

UW Biostatistics Working Paper Series

While the use of Bayesian methods of analysis have become increasingly common, classical frequentist hypothesis testing still holds sway in medical research - especially clinical trials. One major difference between a standard frequentist approach and the most common Bayesian approaches is that even when a frequentist hypothesis test is derived from parametric models, the interpretation and operating characteristics of the test may be considered in a distribution-free manner. Bayesian inference, on the other hand, is often conducted in a parametric setting where the interpretation of the results is dependent on the parametric model. Here we consider a Bayesian counterpart to …

Go to article

Causal Inference In Longitudinal Studies With History-Restricted Marginal Structural Models, Romain Neugebauer, Mark J. Van Der Laan, Ira B. Tager Apr 2005

Causal Inference In Longitudinal Studies With History-Restricted Marginal Structural Models, Romain Neugebauer, Mark J. Van Der Laan, Ira B. Tager

U.C. Berkeley Division of Biostatistics Working Paper Series

Causal Inference based on Marginal Structural Models (MSMs) is particularly attractive to subject-matter investigators because MSM parameters provide explicit representations of causal effects. We introduce History-Restricted Marginal Structural Models (HRMSMs) for longitudinal data for the purpose of defining causal parameters which may often be better suited for Public Health research. This new class of MSMs allows investigators to analyze the causal effect of a treatment on an outcome based on a fixed, shorter and user-specified history of exposure compared to MSMs. By default, the latter represents the treatment causal effect of interest based on a treatment history defined by the …

Go to article

The Bayesian Two-Sample T-Test, Mithat Gonen, Wesley O. Johnson, Yonggang Lu, Peter H. Westfall Apr 2005

The Bayesian Two-Sample T-Test, Mithat Gonen, Wesley O. Johnson, Yonggang Lu, Peter H. Westfall

Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology & Biostatistics Working Paper Series

In this article we show how the pooled-variance two-sample t-statistic arises from a Bayesian formulation of the two-sided point null testing problem, with emphasis on teaching. We identify a reasonable and useful prior giving a closed-form Bayes factor that can be written in terms of the distribution of the two-sample t-statistic under the null and alternative hypotheses respectively. This provides a Bayesian motivation for the two-sample t-statistic, which has heretofore been buried as a special case of more complex linear models, or given only roughly via analytic or Monte Carlo approximations. The resulting formulation of the Bayesian test is easy …

Go to article

Resampling Based Multiple Testing Procedure Controlling Tail Probability Of The Proportion Of False Positives, Mark J. Van Der Laan, Merrill D. Birkner, Alan E. Hubbard Mar 2005

Resampling Based Multiple Testing Procedure Controlling Tail Probability Of The Proportion Of False Positives, Mark J. Van Der Laan, Merrill D. Birkner, Alan E. Hubbard

U.C. Berkeley Division of Biostatistics Working Paper Series

Simultaneously testing a collection of null hypotheses about a data generating distribution based on a sample of independent and identically distributed observations is a fundamental and important statistical problem involving many applications. In this article we propose a new resampling based multiple testing procedure asymptotically controlling the probability that the proportion of false positives among the set of rejections exceeds q at level alpha, where q and alpha are user supplied numbers. The procedure involves 1) specifying a conditional distribution for a guessed set of true null hypotheses, given the data, which asymptotically is degenerate at the true set of …

Go to article

Bayesian Evaluation Of Group Sequential Clinical Trial Designs, Scott S. Emerson, John M. Kittelson, Daniel L. Gillen Mar 2005

Bayesian Evaluation Of Group Sequential Clinical Trial Designs, Scott S. Emerson, John M. Kittelson, Daniel L. Gillen

UW Biostatistics Working Paper Series

Clincal trial designs often incorporate a sequential stopping rule to serve as a guide in the early termination of a study. When choosing a particular stopping rule, it is most common to examine frequentist operating characteristics such as type I error, statistical power, and precision of confi- dence intervals (Emerson, et al. [1]). Increasingly, however, clinical trials are designed and analyzed in the Bayesian paradigm. In this paper we describe how the Bayesian operating characteristics of a particular stopping rule might be evaluated and communicated to the scientific community. In particular, we consider a choice of probability models and a …

Go to article

Implementation Of Estimating-Function Based Inference Procedures With Mcmc Sampler, Lu Tian, Jun S. Liu, L. J. Wei Feb 2005

Implementation Of Estimating-Function Based Inference Procedures With Mcmc Sampler, Lu Tian, Jun S. Liu, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.

Go to article

Fixed-Width Output Analysis For Markov Chain Monte Carlo, Galin L. Jones, Murali Haran, Brian S. Caffo, Ronald Neath Feb 2005

Fixed-Width Output Analysis For Markov Chain Monte Carlo, Galin L. Jones, Murali Haran, Brian S. Caffo, Ronald Neath

Johns Hopkins University, Dept. of Biostatistics Working Papers

Markov chain Monte Carlo is a method of producing a correlated sample in order to estimate features of a complicated target distribution via simple ergodic averages. A fundamental question in MCMC applications is when should the sampling stop? That is, when are the ergodic averages good estimates of the desired quantities? We consider a method that stops the MCMC sampling the first time the width of a confidence interval based on the ergodic averages is less than a user-specified value. Hence calculating Monte Carlo standard errors is a critical step in assessing the output of the simulation. In particular, we …

Go to article

Multiple Testing Procedures And Applications To Genomics, Merrill D. Birkner, Katherine S. Pollard, Mark J. Van Der Laan, Sandrine Dudoit Jan 2005

Multiple Testing Procedures And Applications To Genomics, Merrill D. Birkner, Katherine S. Pollard, Mark J. Van Der Laan, Sandrine Dudoit

U.C. Berkeley Division of Biostatistics Working Paper Series

This chapter proposes widely applicable resampling-based single-step and stepwise multiple testing procedures (MTP) for controlling a broad class of Type I error rates, in testing problems involving general data generating distributions (with arbitrary dependence structures among variables), null hypotheses, and test statistics (Dudoit and van der Laan, 2005; Dudoit et al., 2004a,b; van der Laan et al., 2004a,b; Pollard and van der Laan, 2004; Pollard et al., 2005). Procedures are provided to control Type I error rates defined as tail probabilities for arbitrary functions of the numbers of Type I errors, V_n, and rejected hypotheses, R_n. These error rates include: …

Go to article

Robust Inferences For Covariate Effects On Survival Time With Censored Linear Regression Models, Larry Leon, Tianxi Cai, L. J. Wei Jan 2005

Robust Inferences For Covariate Effects On Survival Time With Censored Linear Regression Models, Larry Leon, Tianxi Cai, L. J. Wei

Harvard University Biostatistics Working Paper Series

Various inference procedures for linear regression models with censored failure times have been studied extensively. Recent developments on efficient algorithms to implement these procedures enhance the practical usage of such models in survival analysis. In this article, we present robust inferences for certain covariate effects on the failure time in the presence of "nuisance" confounders under a semiparametric, partial linear regression setting. Specifically, the estimation procedures for the regression coefficients of interest are derived from a working linear model and are valid even when the function of the confounders in the model is not correctly specified. The new proposals are …

Go to article

On Optimizing Multi-Level Designs: Power Under Budget Constraints, Todd C. Headrick, Bruno D. Zumbo Jan 2005

On Optimizing Multi-Level Designs: Power Under Budget Constraints, Todd C. Headrick, Bruno D. Zumbo

Todd Christopher Headrick

This paper derives a procedure for efficiently allocating the number of units in multi-level designs given prespecified power levels. The derivation of the procedure is based on a constrained optimization problem that maximizes a general form of a ratio of expected mean squares subject to a budget constraint. The procedure makes use of variance component estimates to optimize designs during the budget formulating stages. The method provides more general closed form solutions than other currently available formulae. As such, the proposed procedure allows for the determination of the optimal numbers of units for studies that involve more complex designs. A …

Go to article

More Powerful Unconditional Tests Of No Treatment Effect From Binary Matched Pairs, Chris Lloyd Dec 2004

More Powerful Unconditional Tests Of No Treatment Effect From Binary Matched Pairs, Chris Lloyd

Chris J. Lloyd

This is the workign paper version that preceeded the paper "A New Exact and More Powerful Unconditional Test of no Treatment Effect from Binary Matched Pairs" published in Biometrics 76 (also on this site:http://works.bepress.com/chris_lloyd/3/

Go to article

Identifying A Source Of Financial Volatility, Douglas G. Steigerwald, Richard Vagnoni Dec 2004

Identifying A Source Of Financial Volatility, Douglas G. Steigerwald, Richard Vagnoni

Douglas G. Steigerwald

How should one combine stock and option markets in models of trade and asset price volatility? We address this question, paying particular attention to the identification of parameters of interest.

Go to article

Inferring Information Frequency And Quality, Douglas G. Steigerwald, John Owens Dec 2004

Inferring Information Frequency And Quality, Douglas G. Steigerwald, John Owens

Douglas G. Steigerwald

We develop a microstructure model that, in contrast to previous models, allows one to estimate the frequency and quality of private information. In addition, the model produces stationary asset price and trading volume series. We find evidence that information arrives frequently within a day and that this information is of high quality. The frequent arrival of information, while in contrast to previous microstructure model estimates, accords with nonmodel-based estimates and the related literature testing the mixture-of-distributions hypothesis. To determine if the estimates are correctly reflecting the arrival of latent information, we estimate the parameters over half-hour intervals within the day. …

Go to article

First Prev