Physical Sciences and Mathematics Commons^™

Combinatorial Algorithms For Perturbation Theory And Application On Quantum Computing, Yudong Cao

Open Access Dissertations

Quantum computing is an emerging area between computer science and physics. Numerous problems in quantum computing involve quantum many-body interactions. This dissertation concerns the problem of simulating arbitrary quantum many-body interactions using realistic two-body interactions. To address this issue, a general class of techniques called perturbative reductions (or perturbative gadgets) is adopted from quantum complexity theory and in this dissertation these techniques are improved for experimental considerations. The idea of perturbative reduction is based on the mathematical machinery of perturbation theory in quantum physics. A central theme of this dissertation is then to analyze the combinatorial structure of the perturbation …

Gravity-Assist Trajectories To Venus, Mars, And The Ice Giants: Mission Design With Human And Robotic Applications, Kyle M. Hughes

Open Access Dissertations

Gravity-assist trajectories to Uranus and Neptune are found (with the allowance of impulsive maneuvers using chemical propulsion) for launch dates ranging from 2024 to 2038 for Uranus and 2020 to 2070 for Neptune. Solutions are found using a patched conic model with analytical ephemeris via the Satellite Tour Design Program (STOUR), originally developed at the Jet Propulsion Laboratory (JPL). Delivered payload mass is computed for all solutions for select launch vehicles, and attractive solutions are identified as those that deliver a specified amount of payload mass into orbit at the target body in minimum time. The best cases for each …

Ambient Ionization - Mass Spectrometry: Advances Toward Intrasurgical Cancer Detection, Alan Keith Jarmusch

Open Access Dissertations

My dissertation research has focused on the development of ambient ionization – mass spectrometry (MS) for clinical measurements, specifically intrasurgical cancer detection. The molecular differences between normal and cancerous tissue were detected via direct tissue analysis in vitro by touch spray ionization (TS) or by analyzing sectioned or smeared tissue using desorption electrospray ionization (DESI). The physical form of the tissue, e.g. in vitro sampling, sectioned, or smeared, was inconsequential in differentiating normal from cancerous tissue; however, the spectra acquired by TS and DESI differed due to differences in ionization processes. We envision that TS-MS and DESI-MS could impact diagnostic …

A Framework For The Statistical Analysis Of Mass Spectrometry Imaging Experiments, Kyle Bemis

Open Access Dissertations

Mass spectrometry (MS) imaging is a powerful investigation technique for a wide range of biological applications such as molecular histology of tissue, whole body sections, and bacterial films , and biomedical applications such as cancer diagnosis. MS imaging visualizes the spatial distribution of molecular ions in a sample by repeatedly collecting mass spectra across its surface, resulting in complex, high-dimensional imaging datasets. Two of the primary goals of statistical analysis of MS imaging experiments are classification (for supervised experiments), i.e. assigning pixels to pre-defined classes based on their spectral profiles, and segmentation (for unsupervised experiments), i.e. assigning pixels to newly …

Plasmonic Devices Based On Transparent Conducting Oxides For Near Infrared Applications, Kim Jongbum

Open Access Dissertations

In the past decade, there have been many breakthroughs in the field of plasmonics and nanophotonics that have enabled optical devices with unprecedented functionalities. Even though remarkable demonstration of at photonic devices has been reported, constituent materials are limited to the noble metals such as gold (Au) and silver (Ag) due to their abundance of free electrons which enable the support of plasmon resonances in the visible range. With the strong demand for extension of the optical range of plasmonic applications, it is now a necessity to explore and develop alternative materials which can overcome intrinsic issues of noble metals …

Group Transformation And Identification With Kernel Methods And Big Data Mixed Logistic Regression, Chao Pan

Open Access Dissertations

Exploratory Data Analysis (EDA) is a crucial step in the life cycle of data analysis. Exploring data with effective methods would reveal main characteristics of data and provides guidance for model building. The goal of this thesis is to develop effective and efficient methods for data exploration in the regression setting.

First, we propose to use optimal group transformations as a general approach for exploring the relationship between predictor variables X and the response Y. This approach can be considered an automatic procedure to identify the best characteristic of P( Y|X) under which the relationship …

The Search For Dark Matter In Xenon: Innovative Calibration Strategies And Novel Search Channels, Shayne Edward Reichard

Open Access Dissertations

The direct detection dark matter experiment XENON1T became operational in early 2016, heralding the era of tonne-scale dark matter detectors. Direct detection experiments typically search for elastic scatters of dark matter particles off target nuclei. XENON1T's larger xenon target provides the advantage of stronger dark matter signals and lower background rates compared to its predecessors, XENON10 and XENON100; but, at the same time, calibration of the detector's response to backgrounds with traditional external sources becomes exceedingly more difficult.

A 220Rn source is deployed on the XENON100 dark matter detector in order to address the challenges in calibration of tonne-scale liquid …

Dynamic Holography In Semiconductors And Biomedical Optics, Hao Sun

Open Access Dissertations

Three-dimensional scanning and display are rapidly-advancing new technologies with important commercial drivers such as 3D printing and remote imaging for big data applications. Holography is a natural approach to recording and displaying three-dimensional information because it uses phase-sensitive interferometry to record interference patterns when a reference beam encounters coherent light arriving from an object. The 3D information is contained in the values of wave optics. Holography is a broad field that goes beyond recording and displaying. For instance, holographic optical elements, which take advantage of holographic imaging principles, perform the functions of lenses, gratings or mirrors. Holographic interferometry is also …

Preparative Mass Spectrometry Applications In Nanomaterials And Organic Synthesis, Michael Wleklinski

Open Access Dissertations

Preparative mass spectrometry was traditionally a vacuum based experiment where mass selected ion beams were deposited onto surfaces; however, recently ions have been manipulated in the open air to perform accelerated synthesis. The work of this dissertation focuses on the generation of charged ions from microdroplets and their use in organic synthesis and the preparation of atomically precise metal nanoclusters. First the mechanism for charging in the zero volt paper spray will be presented. This works builds a computational model based on the statistical fluctuation of positive and negative charges based on the theory of Dodd. It is found through …

Synthesis And Performance Of Novel Supramolecular Tools For Single-Particle Cryogenic Electron Microscopy And Drug And Gene Delivery, Kyle J. Wright

Open Access Dissertations

High-resolution biomacromolecular structure elucidation is fundamentally important to structure-based drug design and basic research into complex biochemical processes. Cryo-EM is an emerging alternative to XRD and NMR that is complementary in many ways relative to XRD and NMR. Materials approaches to cryo-EM are anticipated to greatly facilitate the cryo-EM process, allowing progress toward a more high-throughput application of cryo-EM to address challenges in structural biology. ^ Various affinity-based approaches inspired by approaches previously introduced for 2D crystallization were developed for facilitation of cryo-EM. A library of affinity lipopolymer constructs were synthesized consisting of lipopolymers of various PEG molecular weights conjugated …

Computational Environment For Modeling And Analysing Network Traffic Behaviour Using The Divide And Recombine Framework, Ashrith Barthur

Open Access Dissertations

There are two essential goals of this research. The first goal is to design and construct a computational environment that is used for studying large and complex datasets in the cybersecurity domain. The second goal is to analyse the Spamhaus blacklist query dataset which includes uncovering the properties of blacklisted hosts and understanding the nature of blacklisted hosts over time.

The analytical environment enables deep analysis of very large and complex datasets by exploiting the divide and recombine framework. The capability to analyse data in depth enables one to go beyond just summary statistics in research. This deep analysis is …

In-Column Polymer Modifications: Advancing Polymer Bonded Phases, Alexis G. Huckabee

Open Access Dissertations

Glycosylation is the most common post-translational modification affecting protein activities, including delivery to cell surface, binding affinity, and mediating different physiological effects. Separations of glycoproteins and their glycoforms are essential for drug discovery and development, identification of potential disease biomarkers and quality control. The efficiency of glycoprotein separations is limited by the bonded phases, requiring advances in chromatographic materials. Such advances would improve resolution, allowing for more species to be isolated from a mixture and studied.

Our group found that submicrometer nonporous silica stationary phases with tethered polymer chains (acrylamide) give excellent hydrophilic liquid chromatography (HILIC), a common method used …

Wave Propagation And Imaging In Structured Optical Media, Zun Huang

Open Access Dissertations

Structured optical media, usually characterized by periodic patterns of inhomogeneities in bulk materials, provide a new approach to ultimate control of wave propagation with possible practical applications: from distributed feedback lasers by diffraction gratings, to highly nonlinear performance for super-continuum generation, to fiber-optic telecommunications by microstructured photonic crystal fibers, to invisibility cloaking, to super-resolution imaging with metamaterials etc.

In particular, structured optical media allow to manipulate the wave propagation and dispersion. In this thesis, we focus on engineering the propagation phase dispersion by modulating the compositions and dimensions of the periodic elements. By tailoring the dispersion in momentum space, we …

Redox-Active Ligand Uranium Complexes For Approaches To Multi-Electron Chemistry, John J. Kiernicki

Open Access Dissertations

While transition metal complexes are known to participate in multi-electron redox chemistry to facilitate important organometallic transformations, actinides, due to their low redox potentials, have a propensity to perform single electron chemistry. Because of its highly reducing nature, the ability to control the electronics of low-valent uranium is highly sought after as this may lead to unprecedented reactivity. Our lab has specifically been interested in mediating multi-electron transformations at uranium by employing redox-active ligands. Redox-active ligands can be used to facilitate multi-electron processes such as oxidative addition and reductive elimination at single metal centers. Using primarily 2,6-((Mes)N=CMe)2C5H3N) ( MesPDIMe) as …

Functional Regression Models In The Frame Work Of Reproducing Kernel Hilbert Space, Simeng Qu

Open Access Dissertations

The aim of this thesis is to systematically investigate some functional regression models for accurately quantifying the effect of functional predictors. In particular, three functional models are studied: functional linear regression model, functional Cox model, and function-on-scalar model. Both theoretical properties and numerical algorithms are studied in depth. The new models find broad applications in many areas.

For the functional linear regression model, the focus is on testing the nullity of the slope function, and a generalized likelihood ratio test based on easily implementable data-driven estimate is proposed. The quality of the test is measured by the minimal distance between …

Modeling The Impact Of Land Surface Feedbacks On Post Landfall Tropical Cyclones, Subashini Subramanian

Open Access Dissertations

The land surface is an important component of numerical models. The land surface models are modules that control energy partitioning, compute surface exchange coefficients and form the only physical boundary in a regional scale numerical model. Thus, an accurate representation of land surface is critical to compute surface fluxes, represent the boundary layer evolution and affect changes in weather systems. Land surface can affect landfalling tropical cyclones in two ways: (i) when the cyclone is offshore and land can influence cyclones by introducing dry (or moist) air that can weaken (or strengthen) the organized convective structure of cyclones, and (ii) …

Divide And Recombined For Large Complex Data: Nonparametric-Regression Modelling Of Spatial And Seasonal-Temporal Time Series, Xiaosu Tong

Open Access Dissertations

In the first chapter of this dissertation, I briefly introduce one type of nonparametric regression method, namely local polynomial regression, followed by emphasis on one specific application of loess on time series decomposition, called Seasonal Trend Loess (STL). The chapter is closed by the introduction of D\&R; (Divide and Recombined) statistical framework. Data can be divided into subsets, each of which is applied with a statistical analysis method. This is an embarrassing parallel procedure since there is no communication between each subset. Then the analysis result for each subset are combined together to be the final analysis outcome for the …

Numerical Simulations Of Shock Waves Reflection And Interaction, Ligang Sun

Theses and Dissertations

The main objective of this dissertation is to detect and study the phenomena of reflection of one shock wave and interaction of two shock waves using numerical methods. In theory, solutions of non-linear Euler equations of compressive inviscid gas dynamics in two dimensions can display various features including shock waves and rarefaction waves. To capture the shock waves properly, highly accurate numerical schemes are designed according to second order Lax-Wendroff method. In this thesis, three numerical experiments were designed to show the reflection and interaction phenomena. Firstly, one shock was formed due to the encounter of two high speed gas …

Optical Method For High Magnification Imaging And Video Recording Of Live Cells At Sub-Micron Resolution, Jaime E. Romo Jr.

Theses and Dissertations

Optical microscopy, the most common technique for viewing living microorganisms, is limited in resolution by Abbe’s criterion. Recent microscopy techniques focus on circumnavigating the light diffraction limit by using different methods to obtain the topography of the sample. Systems like the AFM and SEM provide images with fields of view in the nanometer range with high resolvable detail, however these techniques are expensive, and limited in their ability to document live cells. The Dino-Lite digital microscope coupled with the Zeiss Axiovert 25 CFL microscope delivers a cost-effective method for recording live cells. Fields of view ranging from 8 microns to …

Monte Carlo Methods In Bayesian Inference: Theory, Methods And Applications, Huarui Zhang

Graduate Theses and Dissertations

Monte Carlo methods are becoming more and more popular in statistics due to the fast development of efficient computing technologies. One of the major beneficiaries of this advent is the field of Bayesian inference. The aim of this thesis is two-fold: (i) to explain the theory justifying the validity of the simulation-based schemes in a Bayesian setting (why they should work) and (ii) to apply them in several different types of data analysis that a statistician has to routinely encounter. In Chapter 1, I introduce key concepts in Bayesian statistics. Then we discuss Monte Carlo Simulation methods in detail. Our …

Measuring Nonlinear Properties Of Graphene Thin Films Using Z-Scan Technique, Thekrayat Hassan Al Abdulaal

Graduate Theses and Dissertations

The nonlinear studies of two-dimensional (2D) nanomaterials, specifically graphene, are very significant since graphene is finding its usefulness in handling the enormous heat in nanoscale high-density power electronics. Graphene has emerged to be a promising nanomaterial as an excellent heat spreader due to its high thermal conductivity. However, the experimental nonlinear study of graphene materials and their application in developing future optoelectronic devices demands for more developed research.

The research objective is first to build a precise, and sensitive technique to investigate and understand the thermal nonlinear properties, including nonlinear refractive index (n2), nonlinear absorption coefficient (β), and thermo-optic coefficient …

Bioorthogonal Reactions: Synthesis And Evaluation Of Different Ligands In Copper Catalyzed Azide-Alkyne1,3-Dipolar Cycloaddition (Cuaac), Zainab Abdullah Almansaf

Graduate Theses and Dissertations

The Copper CatalyzedAzide-Alkyne1,3-Dipolar Cycloaddition (CuAAC) reaction has unique features that qualify it to be one of the best click reactions. Its applications have been shown in different aspects and for multiple purposes. The oxidative degradation of biological systems (labile proteins and live cells) is, however, generally recognized as the major problem when using this reaction in living systems. Reactive oxidation species can be easily produced in the presence of copper(II), ascorbate and air, and this is the main cause of toxicity. However, the uses of ligands have shown a major impact on reducing copper toxicity, protecting Cu(I) from the redox …

Direct Attachment Of 4-Hydroxybenzoic Acid Polymers And Capture Agents To Flat Sheet And Microdialysis Membranes For Improved Mass Transport, Sarah Jane Phillips

Graduate Theses and Dissertations

Microdialysis (MD) sampling is a diffusion-based separation method which has the ability to sample any analyte that can diffuse across the semi-permeable membrane. However one challenge for MD is that for soluble proteins greater than 10 kDa, the relative recovery (RR) using a 100 kDa MD probe is between 1-5%.1 There are two major barriers that lead to these low recovery values - nonspecific adsorption (NSA) and poor solute mass transport. To overcome these two barriers, the modification of PES-based MD membranes has been initiated by laccase. Previous researchers have used laccase to modify PES flat sheet and hollow fiber …

Synthesis, Characterization, And Fabrication Of All Inorganic Quantum Dot Leds, Haider Baqer Salman

Graduate Theses and Dissertations

Quantum Dot LEDs with all inorganic materials are investigated in this thesis. The research was motivated by the potential disruptive technology of core shell quantum dots in lighting and display applications. These devices consisted of three main layers: hole transport layer (HTL), electron transport layer (ETL), and emissive layer where the emission of photons occurs. The latter part was formed of CdSe / ZnS core-shell quantum dots, which were synthesized following hot injection method. The ETL and the HTL were formed of zinc oxide nanocrystals and nickel oxide, respectively. Motivated by the low cost synthesis and deposition, NiO and ZnO …

Fabrication Of Infrared Photodetectors Utilizing Lead Selenide Nanocrystals, Justin Anthony Hill

Graduate Theses and Dissertations

Colloidal lead selenide and lead selenide / lead sulfide core/shell nanocrystals were grown using a wet chemical synthesis procedure. Absorbance and photoluminescence measurements were made to verify the quality of the produced nanocrystals. Absorbance spectra were measured at room temperature, while photoluminescence spectra were measured at 77 K. Organic ligands were exchanged for shorter ligands in order to increase the conductivity of the nanocrystals. Absorption and PL spectra for both core and core/shell nanocrystals were compared. Interdigital photodetector devices with varying channel widths were fabricated by depositing gold onto a glass substrate. Lead selenide nanocrystals were deposited onto these metallic …

Discord And Global Discord In Systems Of Coupled Quantum Dots In Driven Cavities With Dissipation, And A Method For The Calculation Of Global Discord, Willa Danielle Rawlinson

Graduate Theses and Dissertations

In the field of quantum information, which is subdivided into quantum computing and quantum cryptography, quantum correlations are essential for a performance or security boost not achievable with classical means. Various quantum correlation measures exist for evaluating a state’s potential to be a qubit (quantum bit). Entanglement, or nonseparability of quantum states, is the older, better known class of measures. However, for a mixed state, quantum entanglement is an incomplete measure of quantumness. Quantum discord, and its multibody extension global discord, encompass all quantum correlations. We study systems of coupled quantum dots using these measures.

We study the discord of …

Analysis Of Break-Points In Financial Time Series, Jean Remy Habimana

Graduate Theses and Dissertations

A time series is a set of random values collected at equal time intervals; this randomness makes these types of series not easy to predict because the structure of the series may change at any time. As discussed in previous research, the structure of time series may change at any time due to the change in mean and/or variance of the series. Consequently, based on this structure, it is wise not to assume that these series are stationary. This paper, discusses, a method of analyzing time series by considering the entire series non-stationary, assuming there is random change in unconditional …

Interactive Physics And Characteristics Of Photons And Photoelectrons In Hyperbranched Zinc Oxide Nanostructures, Garrett Edward Torix

Graduate Theses and Dissertations

As is commonly known, the world is full of technological wonders, where a multitude of electronic devices and instruments continuously help push the boundaries of scientific knowledge and discovery. These new devices and instruments of science must be utilized at peak efficiency in order to benefit humanity with the most advanced scientific knowledge. In order to attain this level of efficiency, the materials which make up these electronics, or possibly more important, the fundamental characteristics of these materials, must be fully understood. The following research attempted to uncover the properties and characteristics of a selected family of materials. Herein, zinc …

Artificial Quantum Many-Body States In Complex Oxide Heterostructures At Two-Dimensional Limit, Xiaoran Liu

Graduate Theses and Dissertations

As the representative family of complex oxides, transition metal oxides, where the lattice,

charge, orbital and spin degrees of freedom are tightly coupled, have been at the forefront

of condensed matter physics for decades. With the advancement of state-of-the-art heteroepitaxial deposition techniques, it has been recognized that combining these oxides on the atomic scale, the interfacial region offers great opportunities to discover emergent phenomena and tune materials' functionality. However, there still lacks general guiding principles for experimentalists, following which one can design and fabricate artificial systems on demand. The main theme of this dissertation is to devise and propose some …

Embedding Oriented Graphs In Books, Stacey R. Mcadams

Doctoral Dissertations

A book consists of a line L in [special characters omitted]3, called the spine, and a collection of half planes, called pages, whose common boundary is L. A k-book is book with k pages. A k-page book embedding is a continuous one-to-one mapping of a graph G into a book such that the vertices are mapped into L and the edges are each mapped to either the spine or a particular page, such that no two edges cross in any page. Each page contains a planar subgraph of G. The book thickness, denoted bt( …