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Chemistry Faculty Publications

Series

2007

Articles 31 - 36 of 36

Full-Text Articles in Physical Sciences and Mathematics

Tumour Suppressor Function Of Rnase L In A Mouse Model, Wendy Liu, Shu Ling Liang, Hongli Liu, Robert Silverman, Aimin Zhou Jan 2007

Tumour Suppressor Function Of Rnase L In A Mouse Model, Wendy Liu, Shu Ling Liang, Hongli Liu, Robert Silverman, Aimin Zhou

Chemistry Faculty Publications

RNase L is one of the key enzymes involved in the molecular mechanisms of interferon (IFN) actions. Upon binding with its activator, 5′-phosphorylated, 2′-5′ oligoadenylates (2-5A), RNase L plays an important role in the antiviral and anti-proliferative functions of IFN, and exerts proapoptotic activity independent of IFN. In this study, we have found that RNase L retards proliferation in an IFN-dependent and independent fashion. To directly measure the effect of RNase L on tumour growth in the absence of other IFN-induced proteins, human RNase L cDNA was stably expressed in P-57 cells, an aggressive mouse fibrosarcoma cell line. Three clonal …

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Synthesis Of The Giant Dielectric Constant Material Cacu3ti4o12 By Wet-Chemistry Methods, Jianjun Liu, Robert W. Smith, Wai-Ning Mei Jan 2007

Synthesis Of The Giant Dielectric Constant Material Cacu3ti4o12 By Wet-Chemistry Methods, Jianjun Liu, Robert W. Smith, Wai-Ning Mei

Chemistry Faculty Publications

CaCu3Ti4O12 (CCTO) has a giant dielectric constant of up to 105 at room temperature and great potential for technological application. In this work, we report two wet-chemistry methods to synthesize CCTO at relatively low temperatures and short reaction times. The pure-phase sample was obtained at 800 °C for 0.5 h, and the grain size of a pellet sample sintered at 1030 °C has a homogeneous distribution in the range of 0.4–1.5 μm.

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Structure And Antiferroelectric Properties Of Cesium Niobate, Cs2nb4o11, Robert W. Smith, Chunhua Hu, Jianjun Liu, Wai-Ning Mei, Kuan-Jiuh Lin Jan 2007

Structure And Antiferroelectric Properties Of Cesium Niobate, Cs2nb4o11, Robert W. Smith, Chunhua Hu, Jianjun Liu, Wai-Ning Mei, Kuan-Jiuh Lin

Chemistry Faculty Publications

The compound cesium niobate, Cs2Nb4O11, is an antiferroelectric, as demonstrated by double hysteresis loops in the electric-field versus polarization plot. The crystal structure refinement by X-ray diffraction at both 100 and 297 K shows it to have a centrosymmetric structure in point group mmm and orthorhombic space group Pnna, which is consistent with its antiferroelectric behavior. The 100-K data is reported herein. The lattice is comprised of niobium-centered tetrahedra and octahedra connected through shared vertices and edges; cesium atoms occupy channels afforded by the three-dimensional polyhedral network. The critical field for onset of ferroelectric behavior in a single-crystal sample is …

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Reactivation Pathway Of The Hydrogenase H-Cluster: Density Functional Theory Study, Stefan Motiu, Daniela Dogaru, Valentin Gogonea Jan 2007

Reactivation Pathway Of The Hydrogenase H-Cluster: Density Functional Theory Study, Stefan Motiu, Daniela Dogaru, Valentin Gogonea

Chemistry Faculty Publications

This work puts forth a reaction pathway for the reactivation of exogenous ligand inhibited H-cluster, the active site of Fe-only hydrogenases. The H-cluster is a dimetal complex, Fe–Fe, with the metal centers bridged by di(thiomethyl)amine. Exogenous ligands, H2O, and OH−, are bound to the distal iron (Fed). Density functional theory (DFT) calculations on the native and ruthenium-modified H-cluster have been performed using the B3LYP functional with 6-31+G** and 6-311+G** basis sets. We have ascertained that there is a thermodynamically favorable pathway for the reactivation of the OH− inhibited H-cluster, which proceeds by an initial protonation of the Fed–OH− complex. The …

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Identification And Characterization Of A New Tubulin-Binding, Susan L. Mooberry, Kimberly N. Weiderhold, Sivanesan Dakshanamurthy, Ernest Hamel, Edith J. Banner, Anastasia Kharlamova, Jonathan Hempel, John T. Gupton, Milton L. Brown Jan 2007

Identification And Characterization Of A New Tubulin-Binding, Susan L. Mooberry, Kimberly N. Weiderhold, Sivanesan Dakshanamurthy, Ernest Hamel, Edith J. Banner, Anastasia Kharlamova, Jonathan Hempel, John T. Gupton, Milton L. Brown

Chemistry Faculty Publications

We studied the mechanism of action of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (JG-03-14) and found that it is a potent microtubule depolymerizer. JG-03-14 caused a dose-dependent loss of cellular microtubules, formation of aberrant mitotic spindles, accumulation of cells in the G2/M phase of the cell cycle, and Bcl-2 phosphorylation. These events culminated in the initiation of apoptosis, as evidenced by the caspase 3-dependent cleavage of poly(ADP-ribose) polymerase (PARP). JG-03-14 has antiproliferative activity against a wide range of cancer cell lines, with an average IC50 value of 62 nM, and it is a poor substrate for transport …

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Jonas Kamlet (1914-1960) Chemist/Entrepreneur, Dean F. Martin, Barbara B. Martin Jan 2007

Jonas Kamlet (1914-1960) Chemist/Entrepreneur, Dean F. Martin, Barbara B. Martin

Chemistry Faculty Publications

Jonas Kamlet, Ph.D., as a chemist, inventor, and a significant entrepreneur who founded Kamlet Laboratories in New York City that became the model of a successful consulting firm. Among his hundreds of patents and inventions were a tablet that could be used to measure glucose in urine, a treated strip that could detect pregnancy, a fodder for ruminants that used newsprint, and biuret (a self-condensation product of urea) that could be used as a non-protein component of fodder. Following his death in an airplane collision on December 16, 1960, his wife and collaborator (and later a resident of Florida) carried …

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