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Chemistry Faculty Publications
Aromatase; Cyclooxygenase-2; Prostaglandin E2; NSAIDs; COX-2 inhibitors; siRNA; Sulfonanilides
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Full-Text Articles in Physical Sciences and Mathematics
Aromatase And Cox In Breast Cancer: Enzyme Inhibitors And Beyond, Robert W. Brueggemeier, Bin Su, Yasuro Sugimoto, Edgar S. Diaz-Cruz, Danyetta D. Davis
Aromatase And Cox In Breast Cancer: Enzyme Inhibitors And Beyond, Robert W. Brueggemeier, Bin Su, Yasuro Sugimoto, Edgar S. Diaz-Cruz, Danyetta D. Davis
Chemistry Faculty Publications
Aromatase expression and enzyme activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue. Complex regulation of aromatase expression in human tissues involves alternative promoter sites that provide tissue-specific control. Previous studies in our laboratories suggested a strong association between aromatase (CYP19) gene expression and the expression of cyclooxygenase (COX) genes. Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) and COX selective inhibitors can suppress CYP19 gene expression and decrease aromatase activity. Our current hypothesis is that pharmacological regulation of aromatase and/or cyclooxygenases can act locally to decrease the biosynthesis of estrogen and may …