Physical Sciences and Mathematics Commons^™

Development Of A Framework To Support Community-Scale Nutrient Recovery For Local Crop Fertilization And Production, Scott A. Lopez

Graduate Theses, Dissertations, and Problem Reports

Nutrient and resource recovery (NRR) has become increasingly crucial as regions face deteriorating sanitation infrastructures, limited support, and growing environmental challenges. Implementing region-specific NRR technologies and systems could provide effective circular economy insights into addressing these challenges. Because of the multidisciplinary challenges associated with the design and implementation of NRR strategies, various government and local decision-makers need to collaborate effectively in the decision-making process. Structured decision-making (SDM) methodologies are practical when determining the most appropriate NRR strategy for nutrient-rich waste streams. However, applications of computational SDM limited because of the vast amounts of data that are needed to analyze the …

Effects Of Climate Change And Landscape-Scale Forest Management On Avian Communities, Abundance, And Nest Success In The Appalachian Mountains, Hannah L. Clipp

Graduate Theses, Dissertations, and Problem Reports

Birds are integral components of ecosystems and account for billions of dollars in tangible benefits to humans. As such, recent continental declines of bird species have ecological and economic consequences, providing the impetus for my dissertation research. I identified knowledge gaps and proposed novel questions about how birds in the Appalachian Mountains are influenced by changing environmental conditions due to climate change and forest management. The Appalachian Mountains encompass an important biogeographical region with high conservation value due to its myriad habitats and corresponding bird species diversity. Thus, there is a critical need to evaluate the effects of shifting climate …

Quantifying Variation In High-Quality Footwear Replicate Impressions, Samantha K. Brady

Graduate Theses, Dissertations, and Problem Reports

A footwear impression collected at a crime scene can provide information about the shoe that created it, yielding investigative leads, excluding persons-of-interest, and linking evidence between cases. The analysis of footwear evidence often requires the preparation of test impressions from known exemplar shoes created under controlled laboratory conditions for comparison to questioned impressions. The goal of these comparisons is to evaluate the degree of similarities and differences between the questioned impression and potential sources.

Given that this comparison leads to an assessment of the nature and degree of agreement between questioned and known impressions, it is important to characterize the …

Examining The Relations Among Academic And Non-Cognitive Factors And Student Achievement, Dona Sachini Hasanjalie Hewagallage

Graduate Theses, Dissertations, and Problem Reports

Since the 1980s, Physics Education Research (PER) has explored the factors influencing students' success in college. This manuscript reports three different studies to understand the impact of different factors on students' college physics achievement. The first study explored several academic (high school physics preparation, high school preparation, math readiness, and ACT or SAT verbal and mathematics scores) and non-cognitive (self-efficacy, personality, belonging, grade expectation, and demographic) factors using correlation and linear regression analysis to understand their relation to students' physics conceptual understanding measured by the Force and Motion Conceptual Evaluation (FMCE). High school preparation was found to be the most …

Investigating The Interactions Of The Iron-Sulfur Mitochondrial Protein, Mitoneet With Its Binding Partners, Ebenezer Osei Newton

Graduate Theses, Dissertations, and Problem Reports

MitoNEET belongs to the CDGSH Iron-Sulfur Domain (CISD)-gene family of proteins and is a [2Fe-2S] cluster-containing protein found on the outer membrane of mitochondria. The specific functions of mitoNEET/CISD1 remain to be fully elucidated, but the protein is involved in regulating mitochondrial bioenergetics in several metabolic diseases. Unfortunately, drug discovery efforts targeting mitoNEET to improve metabolic disorders are hampered by the lack of ligand-binding assays for this mitochondrial protein. We have developed a protocol amenable for high-throughput screening (HTS) assay, by modifying an ATP fluorescence polarization method to facilitate drug discovery targeting mitoNEET. Based on our observation that adenosine triphosphate …

Studies On Depth And Torsion In Tensor Products Of Modules, Uyen Huyen Thao Le

Graduate Theses, Dissertations, and Problem Reports

This dissertation represents an in-depth exploration of two distinct yet interconnected research topics within commutative algebra: one centered around a conjecture of Huneke and R. Wiegand and the other concerns a depth inequality of Auslander. It consists of the following three papers as well as the author's work under the direction of Professor Olgur Celikbas:

• Remarks on a conjecture of Huneke and Wiegand and the vanishing of (co)homology, Journal of Mathematical Society of Japan Advance Publication. (joint work with Olgur Celikbas, Hiroki Matsui, and Arash Sadeghi).
• An extension of a depth inequality of Auslander, Taiwanese Journal of Mathematics, …

Improving The Health And Safety Of Manufacturing Workers By Detecting And Addressing Personal Protective Equipment (Ppe) Violations In Real-Time With The Use Of Automated Ppe Detection Technology, Joseph Olufemi Fasinu

Graduate Theses, Dissertations, and Problem Reports

The Centers for Disease Control and Prevention (CDC) emphasized that Personal Protective Equipment (PPE) can significantly reduce the risk of occupational injuries and illnesses. However, improper use, failure to use, and other PPE-related violations can still result in injuries and fatalities. Eye and face protection violation has been one of the top 10 most frequently violated OSHA standards in fiscal years 2018, 2019, 2020, 2021 and 2022 consecutively. A common practice among safety professionals to ensure PPE compliance has been to physically inspect or monitor PPE usage among workers, which has been found to be unsustainable on a continuous real-time …

Multimodal Neuron Classification Based On Morphology And Electrophysiology, Aqib Ahmad

Graduate Theses, Dissertations, and Problem Reports

Categorizing neurons into different types to understand neural circuits and ultimately brain function is a major challenge in neuroscience. While electrical properties are critical in defining a neuron, its morphology is equally important. Advancements in single-cell analysis methods have allowed neuroscientists to simultaneously capture multiple data modalities from a neuron. We propose a method to classify neurons using both morphological structure and electrophysiology. Current approaches are based on a limited analysis of morphological features. We propose to use a new graph neural network to learn representations that more comprehensively account for the complexity of the shape of neuronal structures. In …

Synthesis And Pharmacology Of Illudalic Acid And Analogous Chemical Structures, Robert Gaston Jr

Graduate Theses, Dissertations, and Problem Reports

Natural products are the foundation of modern medicine and an inspiration for chemical innovation. Developing new synthetic strategies to complex natural products drives synthetic innovation and promotes pharmacological exploration. As bioactive secondary metabolites of fungi, illudalic acid and associated analogs have unrealized medicinal potential due to synthetic limitations. Illudalic acid is notably the first selective covalent inhibitor of the LAR-PTPs, a class of enzymes linked to many human illnesses, including stimulant addiction. The chemistry herein focuses on optimizing synthetic routes to illudalic acid and associated analogs toward exploring their pharmaceutical potential. We report a second-generation synthesis of illudinine (55% overall …

Linkages Between Atmospheric Circulation, Weather, Climate, Land Cover And Social Dynamics Of The Tibetan Plateau, Shobha Kumari Yadav

Graduate Theses, Dissertations, and Problem Reports

The Tibetan Plateau (TP) is an important landmass that plays a significant role in both regional and global climates. In recent decades, the TP has undergone significant changes due to climate and human activities. Since the 1980s anthropogenic activities, such as the stocking of livestock, land cover change, permafrost degradation, urbanization, highway construction, deforestation and desertification, and unsustainable land management practices, have greatly increased over the TP. As a result, grasslands have undergone rapid degradation and have altered the land surface which in turn has altered the exchange of heat and moisture properties between land and the atmosphere. But gaps …

Exogenous Factors That Impact Huntingtin Aggregation, Adam Skeens

Graduate Theses, Dissertations, and Problem Reports

While expansion of a polyglutamine (polyQ) domain is the immediate cause of huntingtin (htt) aggregation associated with Huntington’s Disease (HD), other cellular factors modify aggregation. These include interactions with cellular membranes, protein biding partners, molecular crowding, and proteinaceous seeds. Here, two important factors are biophysically characterized: 1) the interaction of htt with endomembranes and 2) proteinaceous seeds obtained from a variety of htt-derived peptides. In the first project, the aggregation of htt at bilayer interfaces and in the presence of divalent cations was investigated. A major cellular factor implicated in altered htt aggregation is the binding of lipids. Furthermore, the …

Enabling Technologies For Chemical Synthesis: I. Selective Microwave Heating; Ii. Synthesis And Regioselective Cyclotrimerizations Of Tethered 1,6-Diynes, Amir Tavakoli

Graduate Theses, Dissertations, and Problem Reports

Reaction discoveries, method developments, and technology advancements lie at the heart of synthetic organic chemistry. These innovations are essential for creating and manipulating complex molecules, which are the building blocks of many important chemical compounds, including pharmaceuticals, materials, and agrochemicals. Here, we first describe new methods to prepare neopentylene-tethered (NPT) 1,6-diynes which are valuable substrates for reaction discovery and target-oriented synthesis, especially in benzannulation strategies toward illudalane natural products. NPT 1,6-diynes have been employed as coupling partners in cyclotrimerization reactions for the synthesis of highly substituted benzene rings which present a persistent challenge in chemical synthesis and are underrepresented scaffolds …

Enantioselective Dearomatization Facilitated By Non-Covalent Interactions Of N-Heterocyclic Carbene Catalysts And Pyridinium Salts, Jack A. Patterson

Graduate Theses, Dissertations, and Problem Reports

Dihydropyridines are a practical organic scaffold commonly used for their pharmaceutical properties. Nucleophilic dearomatization of pyridines has proven to be a useful method in obtaining dihydropyridines. By using N-heterocyclic carbene (NHC) organocatalysts, dihydropyridines can be synthesized with high regioselectivity of the 1,4 regioisomer over the 1,2- regioisomer but often with low enantioselectivity. By incorporating non-covalent interaction contact points, we hypothesize that enantioselectivity can be enhanced. By synthesizing numerous NHCs, each proposed to exhibit a different type of non-covalent interaction (i.e., hydrogen bonding or ion pairing), an understanding of the secondary interactions within this reaction system can be studied and …

Emission Spectroscopy Of Ingaas Quantum Dots Via High-Resolution Fabry-Perot Interferometer, Raju Bhai Kc

Graduate Theses, Dissertations, and Problem Reports

Single photons emitted from self-assembled quantum dots have been widely studied to use as a promising qubit for quantum information processing. Therefore, it is critical to fully understand the emission spectra from the quantum dot's excitation if we want to use a single photon as a quantum bit. It is almost impossible to produce rotationally symmetric quantum dots due to various growth conditions and restrictions. So the real quantum dots do not have a perfectly symmetric structure. A broken rotational symmetry causes an asymmetric exchange interaction between electron and hole, leading to a fine structure splitting between two excited states. …

Feature Extraction Of Footwear Impression Images For Quality Assessment, Alexandra Hill

Graduate Theses, Dissertations, and Problem Reports

Forensic footwear impression analysis is a valuable tool in criminal investigations. Extracting useful features from images of footwear impressions is a critical step in this process. However, the quality of these images can vary widely, making feature extraction challenging. In order to give a quality assessment rating to a footwear impression image, the image should first be analyzed to extract features from the impression. In this paper, we present a method to extract features from a 2D grayscale footwear impression image. A Hierarchical Grid Model implementation has been adapted from use on a 3D dataset to assist in finding features, …

An Empirical Analysis Of Algorithms For Simple Stochastic Games, Cody William Klingler

Graduate Theses, Dissertations, and Problem Reports

This thesis presents the findings of a computational study on algorithms for Simple Stochastic Games (SSG). Simple Stochastic Games are a restriction of the Shapley stochastic model motivated by their applications in AI planning, logic synthesis, and theoretical computer science. This thesis seeks to empirically assess the performance of these algorithms to compensate for their lack of strong complexity results. Where applicable, we include both variations of algorithms where stable strategies are computed by a linear-programming and naive approach. These algorithms are evaluated on random inputs, in addition to specific difficult cases that were identified experimentally. We are interested in …

Investigation Of Early Complex Formation Of Huntingtin Protein With And Without Lipids, Alyssa R. Stonebraker

Graduate Theses, Dissertations, and Problem Reports

Huntington’s disease (HD) is a fatal neurodegenerative disease caused by the expansion of the polyglutamine (polyQ) domain of the huntingtin protein (htt). The expansion of the polyQ domain beyond a threshold of approximately 35 repeats triggers complex toxic aggregation mechanisms and results in altered interactions between htt and lipid membranes. Many factors modulate these processes. One such modulator includes sequences flanking the polyQ domain, most notably the first 17 amino acids at the N-terminus of the protein (Nt17), and environmental factors including the presence of membranous structures. Nt17 has the propensity to form an amphipathic a-helix in the presence of …

Copper-Catalyzed Dehydrogenative Decarboxylation Reactions Of Carboxylic Acids To Alkenes, Michael P. Stanton

Graduate Theses, Dissertations, and Problem Reports

Linear alpha olefins (LAOs) are important building blocks in the production of linear low-density polyethylene, a plastic used in products such as shrink wraps, plastic bags, tubing, plasticizers, among others. Commercial methods for generating LAOs utilize ethylene oligomerization, but this method is reliant on fossil fuels and leads to unselective product formation. Synthesis of LAOs from renewable resources, namely carboxylic acids, by decarbonylative dehydration strategies has been well studied, however, this method has inherent drawbacks rooted in the formation of internal olefin side-products through isomerization pathways. With the goal of avoiding internal isomerization, this thesis explores a dehydrogenative decarboxylation strategy …

Rad Rivers In Rad Places: Characterizing The Historical And Future Whitewater Resources In Select Regions Of The United States, Melissa D. Shafer

Graduate Theses, Dissertations, and Problem Reports

Outdoor recreation is a highly profitable industry in the United States. In 2021, outdoor recreation accounted for $454.0 billion, or 1.9% of the current-dollar gross domestic product for the nation. Many states have benefited financially from focusing on promoting their outdoor recreation and natural resources. Whitewater (WW) paddling has been a recreational activity since the 1950s. In 2007 there were an estimated 1.2 million participants in whitewater kayaking. As of 2020, that number increased to 2.6 million, doubling the number of participants. WW resources can be leveraged to reshape local and regional economies. The framework developed in this study provides …

Longitudinal Sport Science Implementation In American Collegiate Men’S Basketball, Jason Stone

Graduate Theses, Dissertations, and Problem Reports

The expanding opportunities to implement sport science frameworks in elite-level basketball environments coincide with the sport’s increasing global prominence. Concomitant to these opportunities is the continual growth of the sport technology market (e.g., wearables, force plates) and computational power (e.g., data management tools, coding capabilities), which yields solutions and challenges for both athletes and practitioners. Due to the rapid influx of new sport technologies in high performance environments, particularly American Collegiate Men’s Basketball, more formal and ecologically valid research on how to effectively utilize data derived from them, particularly over long periods of time (i.e., multiple seasons) is needed. To …

Mapping Infiltration In An Urbanizing Mixed-Land-Use Watershed With Multi-Temporal Satellite Imagery, Sarah J. Higgins

Graduate Theses, Dissertations, and Problem Reports

Digital soil mapping (DSM) is a field of soil science that aims to improve traditional soil maps by producing higher resolution predictive maps of soil properties using spatial environmental data. DSM has historically relied primarily on static environmental covariates—such as slope gradient, slope aspect, and other topographic variables derived from digital terrain models—for predicting static soil properties, like soil texture. Advancements in satellite imagery and statistical modeling improve the accuracy of digital soil maps by incorporating multi-temporal data that can capture landscape-scale change over relatively short periods of time. Adding these dynamic environmental covariates may be especially useful for spatial …

Enhancing The Forensic Comparison Process Of Common Trace Materials Through The Development Of Practical And Systematic Methods, Meghan Nicole Prusinowski

Graduate Theses, Dissertations, and Problem Reports

An ongoing advancement in forensic trace evidence has driven the development of new and objective methods for comparing various materials. While many standard guides have been published for use in trace laboratories, different areas require a more comprehensive understanding of error rates and an urgent need for harmonizing methods of examination and interpretation. Two critical areas are the forensic examination of physical fits and the comparison of spectral data, which depend highly on the examiner’s judgment.

The long-term goal of this study is to advance and modernize the comparative process of physical fit examinations and spectral interpretation. This goal is …

Stability Properties Of A System Of Receptors In The Presence Of Attractive Domains, Basim Mohammed Al-Maliki

Graduate Theses, Dissertations, and Problem Reports

I use mathematical modeling to understand aspects of molecular processes in living cells. Specifically, we look at the first few steps in cell signaling. Signal initiation requires that receptors located on the cell membrane bind together to form dimers. Microscopic imaging of receptors on the cell membrane revealed that receptors tend to accumulate in small areas (clusters). Studies also show that the membrane has a complex landscape consisting of domains and barriers of various origin.

Here we study the way receptor dimerization is influenced by domains on the cell membrane. Our underlying hypothesis is that the physical and chemical properties …

Longest Path And Cycle Transversal And Gallai Families, James A. Long Jr

Graduate Theses, Dissertations, and Problem Reports

A longest path transversal in a graph G is a set of vertices S of G such that every longest path in G has a vertex in S. The longest path transversal number of a graph G is the size of a smallest longest path transversal in G and is denoted lpt(G). Similarly, a longest cycle transversal is a set of vertices S in a graph G such that every longest cycle in G has a vertex in S. The longest cycle transversal number of a graph G is the size of a smallest longest cycle transversal in G and …

Analysis Of ‘Touch’ Dna Recovered From Metal Substrates: An Investigation Into Cfdna-Metal Interactions And The Efficacy Of Different Collection Techniques On Dna Yield, Jessica E. Thornton

Graduate Theses, Dissertations, and Problem Reports

While several improvements have been made in recent years to optimize the recovery of ‘touch’ DNA, relatively little research has been conducted to understand the relationship between ‘touch’ DNA and the binding affinity of that DNA to metal surfaces, specifically those with a significant copper presence. Furthermore, characterization of cell-free DNA (cfDNA) and its contribution to ‘touch’ samples and those cfDNA-metal interactions from objects commonly identified at crime scenes (cartridge casings, knives, doorknobs) have been lacking. Research has identified the tendency of copper ions to intercalate with DNA helices, resulting in sample degradation among other damaging conformational changes; however, while …

Sequence Checking And Deduplication For Existing Fingerprint Databases, Tahsin Islam Sakif

Graduate Theses, Dissertations, and Problem Reports

Biometric technology is a rapidly evolving field with applications that range from access to devices to border crossing and entry/exit processes. Large-scale applications to collect biometric data, such as border crossings result in multimodal biometric databases containing thousands of identities. However, due to human operator error, these databases often contain many instances of image labeling and classification; this is due to the lack of training and throughput pressure that comes with human error. Multiple entries from the same individual may be assigned to a different identity. Rolled fingerprints may be labeled as flat images, a face image entered into a …

On Eulerian Subgraphs And Hamiltonian Line Graphs, Yikang Xie

Graduate Theses, Dissertations, and Problem Reports

A graph {\color{black}$G$} is Hamilton-connected if for any pair of distinct vertices {\color{black}$u, v \in V(G)$}, {\color{black}$G$} has a spanning $(u,v)$-path; {\color{black}$G$} is 1-hamiltonian if for any vertex subset $S \subseteq {\color{black}V(G)}$ with $|S| \le 1$, $G - S$ has a spanning cycle. Let $\delta(G)$, $\alpha'(G)$ and $L(G)$ denote the minimum degree, the matching number and the line graph of a graph $G$, respectively. The following result is obtained. {\color{black} Let $G$ be a simple graph} with $|E(G)| \ge 3$. If $\delta(G) \geq \alpha'(G)$, then each of the following holds. \\ (i) $L(G)$ is Hamilton-connected if and only if $\kappa(L(G))\ge …

Continental Saline Environments Interpreted From Bedded Gypsum Of The Triassic Red Peak Formation (Chugwater Group), Northcentral Wyoming, Maya Yamei Bradford

Graduate Theses, Dissertations, and Problem Reports

Bedded evaporites and associated red bed siliciclastics record saline lake and groundwater systems from Permo-Triassic Pangea. A major component of these red bed and evaporite systems is bedded gypsum. However, little attention has been paid to the textures of ancient gypsum. Observations of gypsum textures can refine interpretations of depositional environment and diagenetic history. This project describes textures of bedded gypsum from an outcrop of the Triassic Red Peak Formation (Chugwater Group) near Greybull, Wyoming.

This thesis uses fieldwork, petrography, and x-ray diffraction to describe an outcrop of the upper Red Peak Formation, with a focus on textures of bedded …

Natural Fracture Evolution: Investigations Into The Middle Devonian Marcellus Shale, Appalachian Basin, Usa, Natalie Abigail Mitchell

Graduate Theses, Dissertations, and Problem Reports

Optimizing recovery from unconventional shale reservoirs has generated considerable research into optimal recovery methods through hydraulic fracturing design and shale reservoir characterization in the development of long-term hydrocarbon producers. Permeability at multiple scales from nanometer-scale pore sizes and nano-darcy permeability to completion-induced fractures defining a 100’s of meter stimulated reservoir volume plays a significant role in hydrocarbon flow during production in shale reservoirs. Preexisting cemented fractures in unconventional shale reservoirs are abundant and preferentially reactivate during induced hydraulic fracturing treatment to create necessary large-scale permeability. While previous investigations have significantly improved our knowledge of shale reservoirs, it has also highlighted …

Exploration Of Metal-Carbonyl Complexes For Decarbonylation Reactions, Rebekah C. Krupa

Graduate Theses, Dissertations, and Problem Reports

In recent years, transition metal-mediated decarbonylation reactions have emerged as an alternative to conventional cross-coupling methods due to the advantages associated with the use of carbonyl-containing functionalities as coupling electrophiles instead of organohalides found in traditional cross-coupling reactions. This, coupled with the ubiquity of carbonyl-containing compounds in pharmaceuticals and non-biodegradable chemicals, has led to the interest in developing efficient systems for transition metal-catalyzed decarbonylation. However, these reactions are commonly limited to stoichiometric amounts of metal reagents due to the strong metal-carbonyl bond formed during transition metal-mediated decarbonylation. With the goal of gaining a better mechanistic understanding of CO dissociation in …