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Full-Text Articles in Physical Sciences and Mathematics

Using Assessments To Promote Growth Mindset In College Algebra, Hannah M. Lewis, Kady Schneiter, David Lane Tait Sep 2023

Using Assessments To Promote Growth Mindset In College Algebra, Hannah M. Lewis, Kady Schneiter, David Lane Tait

Mathematics and Statistics Faculty Publications

Scientific evidence highlights the positive impact of a growth mindset on student achievement. Students with a growth mindset view errors and obstacles as opportunities for growth and welcome challenges and the opportunity to learn from their mistakes. Much has been written about promoting growth mindset through lectures and attitudes, however, assessments can also be an important avenue for encouraging a growth mindset in students. In this paper, we describe how we used assessments to promote growth mindset in a college algebra class. In the sections that follow, we discuss the need for these assessments and the principles that underly their …


I-Optimal Or G-Optimal: Do We Have To Choose?, Stephen J. Walsh, Lu Lu, Christine M. Anderson-Cook Apr 2023

I-Optimal Or G-Optimal: Do We Have To Choose?, Stephen J. Walsh, Lu Lu, Christine M. Anderson-Cook

Mathematics and Statistics Faculty Publications

When optimizing an experimental design for good prediction performance based on an assumed second order response surface model, it is common to focus on a single optimality criterion, either G-optimality, for best worst-case prediction precision, or I-optimality, for best average prediction precision. In this article, we illustrate how using particle swarm optimization to construct a Pareto front of non-dominated designs that balance these two criteria yields some highly desirable results. In most scenarios, there are designs that simultaneously perform well for both criteria. Seeing alternative designs that vary how they balance the performance of G- and I …


Epidemic Highs And Lows: A Stochastic Diffusion Model For Active Cases, Luis F. Gordillo, Priscilla E. Greenwood, Dana Strong Mar 2023

Epidemic Highs And Lows: A Stochastic Diffusion Model For Active Cases, Luis F. Gordillo, Priscilla E. Greenwood, Dana Strong

Mathematics and Statistics Faculty Publications

We derive a stochastic epidemic model for the evolving density of infective individuals in a large population. Data shows main features of a typical epidemic consist of low periods interspersed without breaks of various intensities and duration. In our stochastic differential model, a novel reproductive term combines a factor expressing the recent notion of ‘attenuated Allee effect’ and a capacity factor is controlling the size of the process. Simulation of this model produces sample paths of the stochastic density of infectives, which behave much like long-time Covid-19 case data of recent years. Writing the process as a stochastic diffusion allows …


Symplectic Reduction Along A Submanifold, Peter Crooks, Maxence Mayrand Oct 2022

Symplectic Reduction Along A Submanifold, Peter Crooks, Maxence Mayrand

Mathematics and Statistics Faculty Publications

We introduce the process of symplectic reduction along a submanifold as a uniform approach to taking quotients in symplectic geometry. This construction holds in the categories of smooth manifolds, complex analytic spaces, and complex algebraic varieties, and has an interpretation in terms of derived stacks in shifted symplectic geometry. It also encompasses Marsden-Weinstein-Meyer reduction, Mikami-Weinstein reduction, the pre-images of Poisson transversals under moment maps, symplectic cutting, symplectic implosion, and the Ginzburg-Kazhdan construction of Moore-Tachikawa varieties in topological quantum field theory. A key feature of our construction is a concrete and systematic association of a Hamiltonian G-space 𝔐𝐺,𝑆 to …


Leveraging The "Large" In Large Lecture Statistics Classes, Kady Schneiter, Kimberleigh Felix Hadfield, Jenny Lee Clements Sep 2022

Leveraging The "Large" In Large Lecture Statistics Classes, Kady Schneiter, Kimberleigh Felix Hadfield, Jenny Lee Clements

Mathematics and Statistics Faculty Publications

Being a teacher or a student in a class with a large enrollment can be intimidating. Often, teachers view comforts that are common to small classes as unattainable in a larger class, including knowing students’ names, using active learning, employing group work, and creating group discussion. Students in large classes may find that the class size leads to isolation. At Utah State University, we offer introductory statistics classes for various audiences using a large lecture format. The authors have collectively led these large lectures dozens of times and found that, despite its shortcomings, the large lecture format can be an …


Ground Snow Loads For Asce 7-22 – What Has Changed And Why?, Marc Maguire, Brennan L. Bean, James Harris, Abbie Liel, Scott Russell Feb 2021

Ground Snow Loads For Asce 7-22 – What Has Changed And Why?, Marc Maguire, Brennan L. Bean, James Harris, Abbie Liel, Scott Russell

Mathematics and Statistics Faculty Publications

The changes to the ASCE 7 ground snow load maps proposed for the 2022 edition target a uniform reliability rather than a uniform hazard – an important distinction – and are the first of their kind in ASCE 7. Previously, the ASCE 7 snow loads used a uniform-hazard 50-year mean recurrence interval (MRI) with a 1.6 load factor. The newly proposed loads directly target the safety levels stipulated in Chapter 1 of ASCE 7, resulting in a strength design level load that is to be used with a load factor of 1.0. This paper describes changes in design provisions that …


The 2020 National Snow Load Study, Brennan L. Bean, Marc Maguire, Yan Sun, Jadon Wagstaff, Salam Al-Rubaye, Jesse Wheeler, Scout Jarman, Miranda Rogers Feb 2021

The 2020 National Snow Load Study, Brennan L. Bean, Marc Maguire, Yan Sun, Jadon Wagstaff, Salam Al-Rubaye, Jesse Wheeler, Scout Jarman, Miranda Rogers

Mathematics and Statistics Faculty Publications

The United States has a rich history of snow load studies at the state and national level. The current ASCE 7 snow loads are based on studies performed at the Cold Regions Research and Engineering Laboratory (CRREL) ca. 1980 and updated ca. 1993. The map includes large regions where a site-specific case study is required to establish the load. Many state reports attempt to address the "case-study regions" designated in the current ASCE 7 design snow load requirements. The independently developed state-specific requirements vary in approach, which can lead to discrepancies in requirements at state boundaries. In addition, there has …


Bipartite Dot Product Graphs, Sean Bailey, David E. Brown Jun 2020

Bipartite Dot Product Graphs, Sean Bailey, David E. Brown

Mathematics and Statistics Faculty Publications

Given a bipartite graph G = (X, Y, E), the bipartite dot product representation of G is a function f : X ∪Y → ℝk and a positive threshold t such that for any x ∈ X and y ∈ Y , xy ∈ E if and only if f(x) · f(y) ≥ t. The minimum k such that a bipartite dot product representation exists for G is the bipartite dot product dimension of G, denoted bdp(G). We will show that such representations exist for all bipartite graphs as well as give an upper bound for the bipartite dot …


Linear Operators That Preserve Two Genera Of A Graph, Leroy B. Beasley, Kyung-Tae Kang, Seok-Zun Song Apr 2020

Linear Operators That Preserve Two Genera Of A Graph, Leroy B. Beasley, Kyung-Tae Kang, Seok-Zun Song

Mathematics and Statistics Faculty Publications

If a graph can be embedded in a smooth orientable surface of genus g without edge crossings and can not be embedded on one of genus g − 1 without edge crossings, then we say that the graph has genus g. We consider a mapping on the set of graphs with m vertices into itself. The mapping is called a linear operator if it preserves a union of graphs and it also preserves the empty graph. On the set of graphs with m vertices, we consider and investigate those linear operators which map graphs of genus g to graphs of …


Explicit Ambient Metrics And Holonomy, Ian M. Anderson, Thomas Leistner, Pawel Nurowski Feb 2020

Explicit Ambient Metrics And Holonomy, Ian M. Anderson, Thomas Leistner, Pawel Nurowski

Mathematics and Statistics Faculty Publications

We present three large classes of examples of conformal structures whose Fefferman-Graham ambient metrics can be found explicitly. Our method for constructing these examples rests upon a set of sufficiency conditions under which the Fefferman-Graham equations are assured to reduce to a system of inhomogeneous linear partial differential equations. Our examples include conformal pp-waves and, more importantly, conformal structures that are defined by generic co-rank 3 distributions in dimensions 5 and 6.Our examples illustrate various aspects of the ambient metric construction.

The holonomy algebras of our ambient metrics are studied in detail. In particular, we exhibit a large class of …


Arbitrarily High-Order Unconditionally Energy Stable Schemes For Thermodynamically Consistent Gradient Flow Models, Yuezheng Gong, Jia Zhao, Qi Wang Jan 2020

Arbitrarily High-Order Unconditionally Energy Stable Schemes For Thermodynamically Consistent Gradient Flow Models, Yuezheng Gong, Jia Zhao, Qi Wang

Mathematics and Statistics Faculty Publications

We present a systematic approach to developing arbitrarily high-order, unconditionally energy stable numerical schemes for thermodynamically consistent gradient flow models that satisfy energy dissipation laws. Utilizing the energy quadratization method, we formulate the gradient flow model into an equivalent form with a corresponding quadratic free energy functional. Based on the equivalent form with a quadratic energy, we propose two classes of energy stable numerical approximations. In the first approach, we use a prediction-correction strategy to improve the accuracy of linear numerical schemes. In the second approach, we adopt the Gaussian collocation method to discretize the equivalent form with a quadratic …


Normalized Multi-Bump Solutions For Saturable Schrödinger Equations, Xiaoming Wang, Zhi-Qiang Wang Dec 2019

Normalized Multi-Bump Solutions For Saturable Schrödinger Equations, Xiaoming Wang, Zhi-Qiang Wang

Mathematics and Statistics Faculty Publications

In this paper, we are concerned with the existence of multi-bump solutions for a class of semiclassical saturable Schrödinger equations with an density function:

We prove that, with the density function being radially symmetric, for given integer k ≥ 2 there exist a family of non-radial, k-bump type normalized solutions (i.e., with the L2 constraint) which concentrate at the global maximum points of density functions when ε → 0+. The proof is based on a variational method in particular on a convexity technique and the concentration-compactness method.


Convergence Rates For Empirical Estimation Of Binary Classification Bounds, Salimeh Yasaei Sekeh, Morteza Noshad, Kevin R. Moon, Alfred O. Hero Nov 2019

Convergence Rates For Empirical Estimation Of Binary Classification Bounds, Salimeh Yasaei Sekeh, Morteza Noshad, Kevin R. Moon, Alfred O. Hero

Mathematics and Statistics Faculty Publications

Bounding the best achievable error probability for binary classification problems is relevant to many applications including machine learning, signal processing, and information theory. Many bounds on the Bayes binary classification error rate depend on information divergences between the pair of class distributions. Recently, the Henze–Penrose (HP) divergence has been proposed for bounding classification error probability. We consider the problem of empirically estimating the HP-divergence from random samples. We derive a bound on the convergence rate for the Friedman–Rafsky (FR) estimator of the HP-divergence, which is related to a multivariate runs statistic for testing between two distributions. The FR estimator is …


Feasibility Of Multi-Year Forecast For The Colorado River Water Supply: Time Series Modeling, Brian Plucinski, Yan Sun, Shih-Yu (Simon) Wang, Robert R. Gilies, James Eklund, Chih-Chia Wang Nov 2019

Feasibility Of Multi-Year Forecast For The Colorado River Water Supply: Time Series Modeling, Brian Plucinski, Yan Sun, Shih-Yu (Simon) Wang, Robert R. Gilies, James Eklund, Chih-Chia Wang

Mathematics and Statistics Faculty Publications

The future of the Colorado River water supply (WS) affects millions of people and the US economy. A recent study suggested a cross-basin correlation between the Colorado River and its neighboring Great Salt Lake (GSL). Following that study, the feasibility of using the previously developed multi-year prediction of the GSL water level to forecast the Colorado River WS was tested. Time-series models were developed to predict the changes in WS out to 10 years. Regressive methods and the GSL water level data were used for the depiction of decadal variability of the Colorado River WS. Various time-series models suggest a …


Nonlinear Reaction–Diffusion Process Models Improve Inference For Population Dynamics, Xinyi Lu, Perry J. Williams, Mevin B. Hooten, James A. Powell, Jamie N. Womble, Michael R. Bower Nov 2019

Nonlinear Reaction–Diffusion Process Models Improve Inference For Population Dynamics, Xinyi Lu, Perry J. Williams, Mevin B. Hooten, James A. Powell, Jamie N. Womble, Michael R. Bower

Mathematics and Statistics Faculty Publications

Partial differential equations (PDEs) are a useful tool for modeling spatiotemporal dynamics of ecological processes. However, as an ecological process evolves, we need statistical models that can adapt to changing dynamics as new data are collected. We developed a model that combines an ecological diffusion equation and logistic growth to characterize colonization processes of a population that establishes long‐term equilibrium over a heterogeneous environment. We also developed a homogenization strategy to statistically upscale the PDE for faster computation and adopted a hierarchical framework to accommodate multiple data sources collected at different spatial scales. We highlighted the advantages of using a …


(0,1)-Matrices, Discrepancy And Preservers, Leroy B. Beasley Aug 2019

(0,1)-Matrices, Discrepancy And Preservers, Leroy B. Beasley

Mathematics and Statistics Faculty Publications

Let m and n be positive integers, and let R = (r1, . . . , rm) and S = (s1, . . . , sn) be nonnegative integral vectors. Let A(R,S) be the set of all m × n (0, 1)-matrices with row sum vector R and column vector S. Let R and S be nonincreasing, and let F(R) be the m × n (0, 1)-matrix, where for each i, the ith row of F(R, …


From The Signature Theorem To Anomaly Cancellation, Andreas Malmendier, Michael T. Schultz Aug 2019

From The Signature Theorem To Anomaly Cancellation, Andreas Malmendier, Michael T. Schultz

Mathematics and Statistics Faculty Publications

We survey the Hirzebruch signature theorem as a special case of the Atiyah–Singer index theorem. The family version of the Atiyah–Singer index theorem in the form of the Riemann–Roch–Grothendieck–Quillen (RRGQ) formula is then applied to the complexified signature operators varying along the universal family of elliptic curves. The RRGQ formula allows us to determine a generalized cohomology class on the base of the elliptic fibration that is known in physics as (a measure of) the local and global anomaly. Combining several anomalous operators allows us to cancel the local anomaly on a Jacobian elliptic surface, a construction that is based …


Comparing Design Ground Snow Load Prediction In Utah And Idaho, Brennan L. Bean, Marc Maguire, Yan Sun Jul 2019

Comparing Design Ground Snow Load Prediction In Utah And Idaho, Brennan L. Bean, Marc Maguire, Yan Sun

Mathematics and Statistics Faculty Publications

Snow loads in the western United States are largely undefined due to complex geography and climates, leaving the individual states to publish detailed studies for their region, usually through the local Structural Engineers Association (SEAs). These associations are typically made up of engineers not formally trained to develop or evaluate spatial statistical methods for their regions and there is little guidance from ASCE 7. Furthermore, little has been written to compare the independently developed design ground snow load prediction methods used by various western states. This paper addresses this topic by comparing the accuracy of a variety of spatial methods …


Formation Of Radial Patterns Via Mixed Attractive And Repulsive Interactions For Schrödinger Systems, Jaeyoung Byeon, Youngae Lee, Zhi-Qiang Wang Apr 2019

Formation Of Radial Patterns Via Mixed Attractive And Repulsive Interactions For Schrödinger Systems, Jaeyoung Byeon, Youngae Lee, Zhi-Qiang Wang

Mathematics and Statistics Faculty Publications

This paper is concerned with the asymptotic behavior of least energy vector solutions for nonlinear Schrödinger systems with mixed couplings of attractive and repulsive forces. We focus here on the radially symmetric case while the general studies were already conducted in our earlier work [J. Byeon, Y. Sato, and Z.-Q. Wang, J. Math. Pures Appl. (9), 106 (2016), pp. 477--511], [J. Byeon, Y. Sato, and Z.-Q. Wang, J. Fixed Point Theory Appl., 19 (2017), pp. 559--583]. Though there is still the general phenomenon of component-wise pattern formation with co-existence of partial synchronization and segregation for positive least energy …


Association Of Rare Coding Mutations With Alzheimer Disease And Other Dementias Among Adults Of European Ancestry, Devanshi Patel, Jesse Mez, Badri N. Vardarajan, Lyndsay Staley, Jaeyoon Chung, Xiaoling Zhang, John J. Farrell, Michael J. Rynkiewicz, Lisa A. Cannon-Albright, Craig C. Teerlink, Jeffery Stevens, Chris Corcoran, Et Al. Mar 2019

Association Of Rare Coding Mutations With Alzheimer Disease And Other Dementias Among Adults Of European Ancestry, Devanshi Patel, Jesse Mez, Badri N. Vardarajan, Lyndsay Staley, Jaeyoon Chung, Xiaoling Zhang, John J. Farrell, Michael J. Rynkiewicz, Lisa A. Cannon-Albright, Craig C. Teerlink, Jeffery Stevens, Chris Corcoran, Et Al.

Mathematics and Statistics Faculty Publications

IMPORTANCE Some of the unexplained heritability of Alzheimer disease (AD) may be due to rare variants whose effects are not captured in genome-wide association studies because very large samples are needed to observe statistically significant associations.

OBJECTIVE To identify genetic variants associated with AD risk using a nonstatistical approach.

DESIGN, SETTING, AND PARTICIPANTS Genetic association study in which rare variants were identified by whole-exome sequencing in unrelated individuals of European ancestry from the Alzheimer’s Disease Sequencing Project (ADSP). Data were analyzed between March 2017 and September 2018.

MAIN OUTCOMES AND MEASURES Minor alleles genome-wide and in 95 genes previously associated …


Linear Operators That Preserve The Genus Of A Graph, Leroy B. Beasley, Jeong Han Kim, Seok-Zun Song Mar 2019

Linear Operators That Preserve The Genus Of A Graph, Leroy B. Beasley, Jeong Han Kim, Seok-Zun Song

Mathematics and Statistics Faculty Publications

A graph has genus k if it can be embedded without edge crossings on a smooth orientable surface of genus k and not on one of genus k−1. A mapping of the set of graphs on n vertices to itself is called a linear operator if the image of a union of graphs is the union of their images and if it maps the edgeless graph to the edgeless graph. We investigate linear operators on the set of graphs on n vertices that map graphs of genus k to graphs of genus k and graphs of genus k+1 to graphs …


Prediction Of Stress Increase At Ultimate In Unbonded Tendons Using Sparse Principal Component Analysis, Eric Mckinney, Minwoo Chang, Marc Maguire, Yan Sun Mar 2019

Prediction Of Stress Increase At Ultimate In Unbonded Tendons Using Sparse Principal Component Analysis, Eric Mckinney, Minwoo Chang, Marc Maguire, Yan Sun

Mathematics and Statistics Faculty Publications

While internal and external unbonded tendons are widely utilized in concrete structures, an analytical solution for the increase in unbonded tendon stress at ultimate strength, Δ������, is challenging due to the lack of bond between strand and concrete. Moreover, most analysis methods do not provide high correlation due to the limited available test data. The aim of this paper is to use advanced statistical techniques to develop a solution to the unbonded strand stress increase problem, which phenomenological models by themselves have done poorly. In this paper, Principal Component Analysis (PCA), and Sparse Principal Component Analysis (SPCA) are employed on …


Factors That Influence Mathematical Creativity, Joseph S. Kozlowski, Scott A. Chamberlin, Eric Mann Feb 2019

Factors That Influence Mathematical Creativity, Joseph S. Kozlowski, Scott A. Chamberlin, Eric Mann

Mathematics and Statistics Faculty Publications

Creativity is a psychological construct that has gained research popularity (Akgul & Kaveci, 2016), however it remains a challenging one to define. The variety of definitions promulgated to understand creativity hints at the complexity of the mental process. Furthermore, as a subset of creativity, domain-specific mathematical creativity has also garnered a variety of definitions. The transdisciplinary research on creativity (Sriraman & Haavold, 2017) is seminal in this world of fast-paced innovation, invention, solution, and synthesis. Considering every human being with at least average cognitive abilities possesses the ability to think creatively (Baran, 2011), developing students’ creative talents and abilities must …


Exploring Mortality Rates For Major Causes Of Death In Korea, Hyo Jung Oh, Donng Min Yang, Chong Hyuck Kim, Jae Gyu Jeon, Nam Hyung Jung, Chan Young Kim, Jurgen Symanzik, Hyo Won Oh, Akugizibwe Edwin, Seong Ii Jo, Jeong Yong Ahn Jan 2019

Exploring Mortality Rates For Major Causes Of Death In Korea, Hyo Jung Oh, Donng Min Yang, Chong Hyuck Kim, Jae Gyu Jeon, Nam Hyung Jung, Chan Young Kim, Jurgen Symanzik, Hyo Won Oh, Akugizibwe Edwin, Seong Ii Jo, Jeong Yong Ahn

Mathematics and Statistics Faculty Publications

Background: The trends and patterns of the mortality rates for causes of death are meaningful information. They can provide a basis for national demographic and health care policies by identifying the number, causes, and geographical distribution of deaths.

Objective: To explore and analyze the characteristics of the mortality rates for major causes of death in Korea.

Methods: Some common data analysis methods were used to describe the data. We also used some visualization techniques such as heat maps and line plots to present mortality rates by gender, age, and year.

Results: Our analysis shows the crude …


Upper Bounds For The Isolation Number Of A Matrix Over Semirings, Leroy B. Beasley, Seok-Zun Song Jan 2019

Upper Bounds For The Isolation Number Of A Matrix Over Semirings, Leroy B. Beasley, Seok-Zun Song

Mathematics and Statistics Faculty Publications

Let S be an antinegative semiring. The rank of an m×n matrix B over S is the minimal integer r such that B is a product of an m×r matrix and an r×n matrix. The isolation number of B is the maximal number of nonzero entries in the matrix such that no two entries are in the same column, in the same row, and in a submatrix of B of the form [bi,j bk,j

bi,l bk,l] with nonzero entries. We know that the isolation number of B is …


English Translation Of Einige Gesetze Ueber Die Theilung Der Ebene Und Des Raumes, Justin Heavilin Jan 2019

English Translation Of Einige Gesetze Ueber Die Theilung Der Ebene Und Des Raumes, Justin Heavilin

Mathematics and Statistics Faculty Publications

The article “Einige Gesetze ueber die Theilung der Ebene und des Raumes.” was published by J. Steiner in the very first volumn of the Journal fuer die reine und angewandte Mathematik in 1826. Journal fuer die reine und angewandte Mathematik is the oldest mathematics periodical in existence.† . My translation is meant to convey the ideas published by Steiner, and when presented with the choice between translating faithfully to the original text or clarity of his ideas, I admit to choosing the later. There are two footnotes original to the text, which appear with asterisks. Where helpful I included additional …


Power In Pairs: Assessing The Statistical Value Of Paired Samples In Tests For Differential Expression, John R. Stevens, Jennifer S. Herrick, Roger K. Wolff, Martha L. Slattery Dec 2018

Power In Pairs: Assessing The Statistical Value Of Paired Samples In Tests For Differential Expression, John R. Stevens, Jennifer S. Herrick, Roger K. Wolff, Martha L. Slattery

Mathematics and Statistics Faculty Publications

Background: When genomics researchers design a high-throughput study to test for differential expression, some biological systems and research questions provide opportunities to use paired samples from subjects, and researchers can plan for a certain proportion of subjects to have paired samples. We consider the effect of this paired samples proportion on the statistical power of the study, using characteristics of both count (RNA-Seq) and continuous (microarray) expression data from a colorectal cancer study.

Results: We demonstrate that a higher proportion of subjects with paired samples yields higher statistical power, for various total numbers of samples, and for various strengths of …


Logarithmic Hennings Invariants For Restricted Quantum Sl (2), Anna Beliakova, Christian Blanchet, Alexandra Tebbs Dec 2018

Logarithmic Hennings Invariants For Restricted Quantum Sl (2), Anna Beliakova, Christian Blanchet, Alexandra Tebbs

Mathematics and Statistics Faculty Publications

We construct a Hennings-type logarithmic invariant for restricted quantum sl (2) at a 2pth root of unity. This quantum group U is not quasitriangular and hence not ribbon, but factorizable. The invariant is defined for a pair: a 3–manifold M and a colored link L inside M. The link L is split into two parts colored by central elements and by trace classes, or elements in the 0th Hochschild homology of U, respectively. The two main ingredients of our construction are the universal invariant of a string link with values in tensor powers of U, and the modified …


Developmental Parameters Of A Southern Mountain Pine Beetle (Coleoptera: Curculionidae) Population Reveal Potential Source Of Latitudinal Differences In Generation Time, Anne E. Mcmanis, James A. Powell, Barbara J. Bentz Nov 2018

Developmental Parameters Of A Southern Mountain Pine Beetle (Coleoptera: Curculionidae) Population Reveal Potential Source Of Latitudinal Differences In Generation Time, Anne E. Mcmanis, James A. Powell, Barbara J. Bentz

Mathematics and Statistics Faculty Publications

Mountain pine beetle (Dendroctonus ponderosae, Hopkins) is a major disturbance agent in pine ecosystems of western North America. Adaptation to local climates has resulted in primarily univoltine generation time across a thermally diverse latitudinal gradient. We hypothesized that voltinism patterns have been shaped by selection for slower developmental rates in southern populations inhabiting warmer climates. To investigate traits responsible for latitudinal differences we measured lifestage-specific development of southern mountain pine beetle eggs, larvae and pupae across a range of temperatures. Developmental rate curves were fit using maximum posterior likelihood estimation with a Bayesian prior to improve fit stability. …


Genome-Wide Association Study For Variants That Modulate Relationships Between Cerebrospinal Fluid Amyloid-Beta 42, Tau, And P-Tau Levels, Taylor J. Maxwell, Chris Corcoran, Jorge L. Del-Aguila, John P. Budde, Yuetiva Deming, Carlos Cruchaga, Alison M. Goate, John S. K. Kauwe, Alzheimer's Disease Neuroimaging Initiative Aug 2018

Genome-Wide Association Study For Variants That Modulate Relationships Between Cerebrospinal Fluid Amyloid-Beta 42, Tau, And P-Tau Levels, Taylor J. Maxwell, Chris Corcoran, Jorge L. Del-Aguila, John P. Budde, Yuetiva Deming, Carlos Cruchaga, Alison M. Goate, John S. K. Kauwe, Alzheimer's Disease Neuroimaging Initiative

Mathematics and Statistics Faculty Publications

Background: A relationship quantitative trait locus exists when the correlation between multiple traits varies by genotype for that locus. Relationship quantitative trait loci (rQTL) are often involved in gene-by-gene (G×G) interactions or gene-by-environmental interactions, making them a powerful tool for detecting G×G.

Methods: We performed genome-wide association studies to identify rQTL between tau and Aβ42 and ptau and Aβ42 with over 3000 individuals using age, gender, series, APOE ε2, APOE ε4, and two principal components for population structure as covariates. Each significant rQTL was separately screened for interactions with other loci for each trait in the rQTL model. Parametric bootstrapping …