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Full-Text Articles in Physical Sciences and Mathematics
Association Of Rare Coding Mutations With Alzheimer Disease And Other Dementias Among Adults Of European Ancestry, Devanshi Patel, Jesse Mez, Badri N. Vardarajan, Lyndsay Staley, Jaeyoon Chung, Xiaoling Zhang, John J. Farrell, Michael J. Rynkiewicz, Lisa A. Cannon-Albright, Craig C. Teerlink, Jeffery Stevens, Chris Corcoran, Et Al.
Association Of Rare Coding Mutations With Alzheimer Disease And Other Dementias Among Adults Of European Ancestry, Devanshi Patel, Jesse Mez, Badri N. Vardarajan, Lyndsay Staley, Jaeyoon Chung, Xiaoling Zhang, John J. Farrell, Michael J. Rynkiewicz, Lisa A. Cannon-Albright, Craig C. Teerlink, Jeffery Stevens, Chris Corcoran, Et Al.
Mathematics and Statistics Faculty Publications
IMPORTANCE Some of the unexplained heritability of Alzheimer disease (AD) may be due to rare variants whose effects are not captured in genome-wide association studies because very large samples are needed to observe statistically significant associations.
OBJECTIVE To identify genetic variants associated with AD risk using a nonstatistical approach.
DESIGN, SETTING, AND PARTICIPANTS Genetic association study in which rare variants were identified by whole-exome sequencing in unrelated individuals of European ancestry from the Alzheimer’s Disease Sequencing Project (ADSP). Data were analyzed between March 2017 and September 2018.
MAIN OUTCOMES AND MEASURES Minor alleles genome-wide and in 95 genes previously associated …