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An Investigation Of The Behavioral Effects Of Methylphenidate Hydrochloride On Schedule-Induced Polydipsia In Rats, Linda Sederquist Smith

Masters Theses

The influence of methylphenidate hydrochloride injections on six male Charles River rats displaying schedule induced polydipsia was examined in this study. Bar pressing, licking, and water consumption were measured during a total of 63 daily one hour trials conducted with a variable interval 60-second schedule of bar pressing for pellets with water constantly available. The polydipsic response was acquired by subjects during the first 28 trials. Subjects were then divided into experimental and control groups. The experimental subjects recieved a 1 mg/kg injection of methylphenidate prior to regular trials 29-49 and extinction trials 50-63. Control subjects were injected with a …