Veterinary Microbiology and Immunobiology Commons^™

Monoclonal Antibodies To Avian Escherichia Coli Iss, Steven L. Foley, Shelley M. Horne, Catherine W. Giddings, Thomas R. Gustad, Erick D. Handegard, Michael Robinson, Lisa K. Nolan

Lisa K. Nolan

Escherichia coli infections are a major problem for the poultry industry in the United States. Yet, the virulence mechanisms operative in avian E. coli are poorly understood. In the present studies, monoclonal antibodies (MAbs) have been generated that may facilitate study of the pathogenesis of avian colibacillosis. These MAbs are directed against the Iss protein because results from our laboratory have shown that the possession of iss DNA sequences is strongly correlated with the E. coli implicated in avian colibacillosis. As part of an overall effort to explore the role of iss/Iss in colibacillosis pathogenesis, Iss protein has been purified, …