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Veterinary Microbiology and Immunobiology Commons™
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Full-Text Articles in Veterinary Microbiology and Immunobiology
Efficacy Of A Doxycycline Treatment Regimen Initiated During Three Different Phases Of Experimental Ehrlichiosis, Jennifer C. Mcclure, Michelle L. Crothers, John J. Schaefer, Patrick D. Stanley, Glen R. Needham, S A. Ewing, Roger W. Stich
Efficacy Of A Doxycycline Treatment Regimen Initiated During Three Different Phases Of Experimental Ehrlichiosis, Jennifer C. Mcclure, Michelle L. Crothers, John J. Schaefer, Patrick D. Stanley, Glen R. Needham, S A. Ewing, Roger W. Stich
John J Schaefer
Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences outcomes of these treatments. The purpose of this study was to evaluate the efficacy of a 28-day doxycycline regimen for clearance of experimental E. canis infections from dogs treated during three phases of the disease. Ten dogs were inoculated with blood from E. canis carriers and treated with doxycycline during acute, subclinical, or chronic phases of CME. Daily …